Pilot-scale production of Bacillus subtilis MSCL 897 spore biomass and antifungal secondary metabolites in a low-cost medium.
Bacillus subtilis
Antifungal metabolite
Biofungicide
Low-cost medium
Pilot-scale bioreactor
Spore production
Journal
Biotechnology letters
ISSN: 1573-6776
Titre abrégé: Biotechnol Lett
Pays: Netherlands
ID NLM: 8008051
Informations de publication
Date de publication:
12 Apr 2024
12 Apr 2024
Historique:
received:
07
11
2023
accepted:
10
03
2024
revised:
05
03
2024
medline:
12
4
2024
pubmed:
12
4
2024
entrez:
12
4
2024
Statut:
aheadofprint
Résumé
Bacillus subtilis is a plant growth promoting bacterium (PGPB) that acts as a microbial fertilizer and biocontrol agent, providing benefits such as boosting crop productivity and improving nutrient content. It is able to produce secondary metabolites and endospores simultaneously, enhancing its ability to survive in unfavorable conditions and eliminate competing microorganisms. Optimizing cultivation methods to produce B. subtilis MSCL 897 spores on an industrial scale, requires a suitable medium, typically made from food industry by-products, and optimal temperature and pH levels to achieve high vegetative cell and spore densities with maximum productivity. This research demonstrates successful pilot-scale (100 L bioreactor) production of a biocontrol agent B. subtilis with good spore yields (1.5 × 10 An economically-feasible process for B. subtilis-based biocontrol agent production was successfully developed at the pilot scale.
Identifiants
pubmed: 38607603
doi: 10.1007/s10529-024-03481-4
pii: 10.1007/s10529-024-03481-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Regional Development Fund
ID : 1.1.1.1/19/A/150
Organisme : Latvian State Institute of Wood Chemistry
ID : 07-23 (SubtScale)
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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