Design, Synthesis, Computational Studies, and Anti-Proliferative Evaluation of Novel Ethacrynic Acid Derivatives Containing Nitrogen Heterocycle, Urea, and Thiourea Moieties as Anticancer Agents.

ADMET properties GSTP1-1 anti-proliferative caspase 3 drug-likeness ethacrynic acid molecular docking nitrogen heterocycle thiourea urea

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
23 Mar 2024
Historique:
received: 12 02 2024
revised: 18 03 2024
accepted: 19 03 2024
medline: 13 4 2024
pubmed: 13 4 2024
entrez: 13 4 2024
Statut: epublish

Résumé

In the present work, the synthesis of new ethacrynic acid (

Identifiants

DOI: 10.3390/molecules29071437 PMID: 38611717
pubmed: 38611717
pii: molecules29071437
doi: 10.3390/molecules29071437
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Abdelmoula El Abbouchi (A)

Euromed Research Center, Euromed Faculty of Pharmacy, School of Engineering in Biomedical and Biotechnology, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco.
Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orléans, France.
ORCID: 0000-0002-0296-4044

Khaoula Mkhayar (K)

Laboratory of Engineering, Systems and Applications, National School of Applied Sciences, Sidi Mohamed Ben Abdellah-Fez University, Fez 30040, Morocco.
ORCID: 0000-0001-9542-7725

Souad Elkhattabi (S)

Laboratory of Engineering, Systems and Applications, National School of Applied Sciences, Sidi Mohamed Ben Abdellah-Fez University, Fez 30040, Morocco.

Nabil El Brahmi (N)

Euromed Research Center, Euromed Faculty of Pharmacy, School of Engineering in Biomedical and Biotechnology, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco.

Marie-Aude Hiebel (MA)

Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orléans, France.
ORCID: 0000-0001-9476-9176

Jérôme Bignon (J)

Institut de Chimie des Substances Naturelles, CNRS, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.
ORCID: 0000-0002-6294-9671

Gérald Guillaumet (G)

Euromed Research Center, Euromed Faculty of Pharmacy, School of Engineering in Biomedical and Biotechnology, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco.
Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orléans, France.

Franck Suzenet (F)

Institut de Chimie Organique et Analytique, Université d'Orléans, UMR CNRS 7311, BP 6759, CEDEX 2, 45067 Orléans, France.
ORCID: 0000-0003-1394-1603

Saïd El Kazzouli (S)

Euromed Research Center, Euromed Faculty of Pharmacy, School of Engineering in Biomedical and Biotechnology, Euromed University of Fes (UEMF), Meknes Road, Fez 30000, Morocco.
ORCID: 0000-0001-5021-3571

Classifications MeSH