Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation.

MACE PAR1 atrial fibrillation atrial myopathy protease-activated receptor 1 thrombin thrombo-inflammation tissue factor

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
08 Apr 2024
Historique:
received: 26 01 2024
revised: 26 03 2024
accepted: 05 04 2024
medline: 13 4 2024
pubmed: 13 4 2024
entrez: 13 4 2024
Statut: epublish

Résumé

Patients with first-diagnosed atrial fibrillation (FDAF) exhibit major adverse cardiovascular events (MACEs) during follow-up. Preclinical models have demonstrated that thrombo-inflammation mediates adverse cardiac remodeling and atherothrombotic events. We have hypothesized that thrombin activity (FIIa) links coagulation with inflammation and cardiac fibrosis/dysfunction. Surrogate markers of the thrombo-inflammatory response in plasma have not been characterized in FDAF. In this prospective longitudinal study, patients presenting with FDAF (

Identifiants

DOI: 10.3390/ijms25074109 PMID: 38612918
pubmed: 38612918
pii: ijms25074109
doi: 10.3390/ijms25074109
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : German Cardiac Society
ID : DGK03/2021
Organisme : Deutsche Herzstiftung
ID : F/14/20
Organisme : Berlin Institute of Health at Charité - Universitätsmedizin Berlin
ID : CSP
Organisme : Deutsche Forschungsgemeinschaft
ID : WI 5229/1-1

Auteurs

Julian Friebel (J)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.
Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
ORCID: 0000-0002-8093-8423

Max Wegner (M)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.

Leon Blöbaum (L)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.

Philipp-Alexander Schencke (PA)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.

Kai Jakobs (K)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.

Marianna Puccini (M)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.

Emily Ghanbari (E)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.

Stella Lammel (S)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.

Tharusan Thevathasan (T)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.
Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
ORCID: 0000-0003-4698-4079

Verena Moos (V)

Medical Department I, Gastroenterology, Infectious Diseases and Rheumatology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 12203 Berlin, Germany.
ORCID: 0000-0002-9558-7291

Marco Witkowski (M)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.
Friede Springer Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 12203 Berlin, Germany.

Ulf Landmesser (U)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.
Berlin Institute of Health at Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Friede Springer Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 12203 Berlin, Germany.

Ursula Rauch-Kröhnert (U)

Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.
Friede Springer Cardiovascular Prevention Center at Charité, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 12203 Berlin, Germany.

Classifications MeSH