Association of Fructosamine Levels with Glycemic Control in Children with Type 1 Diabetes as Determined by Continuous Glucose Monitoring: Results from the CGM TIME Trial.

To determine the correlation between fructosamine, used to assess glycemia when HbA1c is not appropriate, with average blood glucose as measured by continuous glucose monitoring (CGM) in children with type 1 diabetes. 97 blood samples were collected from 70 participants in the CGM TIME Trial. Each eligible participant had 3 weeks of CGM data with at least 60% CGM adherence prior to blood collection. Ordinary least squares linear regression incorporating restricted cubic splines was used to determine association between fructosamine and mean blood glucose. An association was found between fructosamine levels and mean blood glucose with F-statistic of 9.543 p-value <0.001). Data were used to create formulae and a conversion chart for calculating mean blood glucose from fructosamine levels for clinical use. There is a complex relationship between average blood glucose and fructosamine.

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