The therapeutic effect of proteinase-activated receptor-1 antagonist on colitis-associated carcinogenesis.
Colitis-associated carcinogenesis
Inflammatory bowel disease
PAR(1) antagonist
Proteinase-activated receptor-1
thrombin
Journal
Cellular and molecular gastroenterology and hepatology
ISSN: 2352-345X
Titre abrégé: Cell Mol Gastroenterol Hepatol
Pays: United States
ID NLM: 101648302
Informations de publication
Date de publication:
11 Apr 2024
11 Apr 2024
Historique:
received:
19
12
2023
revised:
30
03
2024
accepted:
03
04
2024
medline:
14
4
2024
pubmed:
14
4
2024
entrez:
13
4
2024
Statut:
aheadofprint
Résumé
Inflammatory bowel disease is associated with carcinogenesis, which limits the prognosis of the patients. The local expression of proteinases and proteinase-activated receptor 1 (PAR A colitis-associated carcinogenesis model was prepared in mice by treatment with azoxymethane (AOM) and dextran sulfate sodium (DSS). PAR AOM/DSS model showed weight loss, diarrhea, tumor development, inflammation, fibrosis, and increased production of inflammatory cytokines. The β-diversity, but not α-diversity, of microbiota significantly differed between AOM/DSS and control mice. E5555 alleviated these pathological changes and altered the microbiota β-diversity in AOM/DSS mice. The thrombin expression was upregulated in tumor and non-tumor areas, while PAR PAR
Sections du résumé
BACKGROUND & AIMS
OBJECTIVE
Inflammatory bowel disease is associated with carcinogenesis, which limits the prognosis of the patients. The local expression of proteinases and proteinase-activated receptor 1 (PAR
METHODS
METHODS
A colitis-associated carcinogenesis model was prepared in mice by treatment with azoxymethane (AOM) and dextran sulfate sodium (DSS). PAR
RESULTS
RESULTS
AOM/DSS model showed weight loss, diarrhea, tumor development, inflammation, fibrosis, and increased production of inflammatory cytokines. The β-diversity, but not α-diversity, of microbiota significantly differed between AOM/DSS and control mice. E5555 alleviated these pathological changes and altered the microbiota β-diversity in AOM/DSS mice. The thrombin expression was upregulated in tumor and non-tumor areas, while PAR
CONCLUSIONS
CONCLUSIONS
PAR
Identifiants
pubmed: 38614455
pii: S2352-345X(24)00071-7
doi: 10.1016/j.jcmgh.2024.04.001
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.