Vitreous humor in the forensic toxicology of quetiapine and its metabolites.
Forensic toxicology
GC/MS
Quetiapine
Vitreous humor
Journal
Forensic toxicology
ISSN: 1860-8965
Titre abrégé: Forensic Toxicol
Pays: Japan
ID NLM: 101315563
Informations de publication
Date de publication:
14 Apr 2024
14 Apr 2024
Historique:
received:
12
12
2023
accepted:
19
03
2024
medline:
14
4
2024
pubmed:
14
4
2024
entrez:
14
4
2024
Statut:
aheadofprint
Résumé
Τhe aim of the present study was to investigate the use of vitreous humor as an alternative biological material in forensic toxicology for the determination of quetiapine, 7-hydroxy-quetiapine, and nor-quetiapine. The distribution of these substances in vitreous humor was studied by determining and correlating their concentrations in vitreous humor with the respective concentrations in blood. During this study, a method for the determination of these substances was developed, validated and applied to postmortem samples obtained from 16 relative forensic cases. The sample preparation procedure included the isolation of the analytes from vitreous humor and blood samples using solid-phase extraction, with Bond Elut LRC C18 columns followed by derivatization with BSTFA with 1% TMCS prior to GC/MS analysis. The developed method is characterized by a dynamic range of 10.0-1000.0 ng/mL (R The results of the study indicate the usefulness of vitreous humor in toxicological analysis for the determination of these substances, especially when the traditional biological materials are not available. The levels of quetiapine and its metabolites in vitreous humor as well as the vitreous humor to blood concentration ratios can provide important information for a more thorough toxicological investigation of forensic cases.
Identifiants
pubmed: 38615314
doi: 10.1007/s11419-024-00687-z
pii: 10.1007/s11419-024-00687-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
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