NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells.

CD8 cells CP: Immunology HCMV HLA-DP NK cells NKp44

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
12 Apr 2024
Historique:
received: 30 10 2023
revised: 03 03 2024
accepted: 26 03 2024
medline: 14 4 2024
pubmed: 14 4 2024
entrez: 14 4 2024
Statut: aheadofprint

Résumé

Although natural killer (NK) cells are recognized for their modulation of immune responses, the mechanisms by which human NK cells mediate immune regulation are unclear. Here, we report that expression of human leukocyte antigen (HLA)-DP, a ligand for the activating NK cell receptor NKp44, is significantly upregulated on CD8

Identifiants

DOI: 10.1016/j.celrep.2024.114089 PMID: 38615318
pubmed: 38615318
pii: S2211-1247(24)00417-0
doi: 10.1016/j.celrep.2024.114089
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114089

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Benedetta Padoan (B)

Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany.

Christian Casar (C)

Bioinformatics Core, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Jenny Krause (J)

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.

Christoph Schultheiss (C)

Division of Medical Oncology, University Hospital Basel, 4031 Basel, Switzerland; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, 4031 Basel, Switzerland.

Martin E Baumdick (ME)

Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Annika Niehrs (A)

Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany.

Britta F Zecher (BF)

Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Maria Pujantell (M)

Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany.

Yuko Yuki (Y)

Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

Maureen Martin (M)

Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

Ester B M Remmerswaal (EBM)

Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Tamara Dekker (T)

Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Nelly D van der Bom-Baylon (ND)

Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Janelle A Noble (JA)

Department of Pediatrics UCSF, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA.

Mary Carrington (M)

Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

Frederike J Bemelman (FJ)

Renal Transplant Unit, Division of Internal Medicine, Academic Medical Centre, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Rene A W van Lier (RAW)

University Medical Center Utrecht, Utrecht, the Netherlands.

Mascha Binder (M)

Division of Medical Oncology, University Hospital Basel, 4031 Basel, Switzerland; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, 4031 Basel, Switzerland.

Nicola Gagliani (N)

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany.

Madeleine J Bunders (MJ)

Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany.

Marcus Altfeld (M)

Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany. Electronic address: marcus.altfeld@leibniz-liv.de.

Classifications MeSH