Residential exposure to traffic pollution and mammographic density in premenopausal women.
Air pollution
Breast cancer
Breast density
DDM-Madrid
Premenopausal
Traffic exposure
Journal
The Science of the total environment
ISSN: 1879-1026
Titre abrégé: Sci Total Environ
Pays: Netherlands
ID NLM: 0330500
Informations de publication
Date de publication:
12 Apr 2024
12 Apr 2024
Historique:
received:
02
02
2024
revised:
11
04
2024
accepted:
11
04
2024
pubmed:
15
4
2024
medline:
15
4
2024
entrez:
14
4
2024
Statut:
aheadofprint
Résumé
Mammographic density (MD) is the most important breast cancer biomarker. Ambient pollution is a carcinogen, and its relationship with MD is unclear. This study aims to explore the association between exposure to traffic pollution and MD in premenopausal women. This Spanish cross-sectional study involved 769 women attending gynecological examinations in Madrid. Annual Average Daily Traffic (AADT), extracted from 1944 measurement road points provided by the City Council of Madrid, was weighted by distances (d) between road points and women's addresses to develop a Weighted Traffic Exposure Index (WTEI). Three methods were employed: method-1 (1dAADT), method-2 (1dAADT), and method-3 (e Results showed no association between MD and traffic pollution according to buffers of exposure to the WTEI (first strategy) for the three methods. The highest reductions in MD, although not statistically significant, were detected in the quartile with the highest traffic exposure. For instance, method-3 revealed a suggestive inverse trend (e Our results showed no association between exposure to traffic pollution and MD in premenopausal women. Further research is needed to validate these findings.
Sections du résumé
BACKGROUND
BACKGROUND
Mammographic density (MD) is the most important breast cancer biomarker. Ambient pollution is a carcinogen, and its relationship with MD is unclear. This study aims to explore the association between exposure to traffic pollution and MD in premenopausal women.
METHODOLOGY
METHODS
This Spanish cross-sectional study involved 769 women attending gynecological examinations in Madrid. Annual Average Daily Traffic (AADT), extracted from 1944 measurement road points provided by the City Council of Madrid, was weighted by distances (d) between road points and women's addresses to develop a Weighted Traffic Exposure Index (WTEI). Three methods were employed: method-1 (1dAADT), method-2 (1dAADT), and method-3 (e
RESULTS
RESULTS
Results showed no association between MD and traffic pollution according to buffers of exposure to the WTEI (first strategy) for the three methods. The highest reductions in MD, although not statistically significant, were detected in the quartile with the highest traffic exposure. For instance, method-3 revealed a suggestive inverse trend (e
CONCLUSIONS
CONCLUSIONS
Our results showed no association between exposure to traffic pollution and MD in premenopausal women. Further research is needed to validate these findings.
Identifiants
pubmed: 38615764
pii: S0048-9697(24)02609-3
doi: 10.1016/j.scitotenv.2024.172463
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
172463Informations de copyright
Copyright © 2024 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.