Myoclonus and Dystonia as Recurrent Presenting Features in Patients with the SCA21-Associated

Dystonia Myoclonus Pro170Leu SCA21 Spinocerebellar ataxia TMEM240

Journal

Tremor and other hyperkinetic movements (New York, N.Y.)
ISSN: 2160-8288
Titre abrégé: Tremor Other Hyperkinet Mov (N Y)
Pays: England
ID NLM: 101569493

Informations de publication

Date de publication:
2024
Historique:
received: 11 01 2024
accepted: 23 03 2024
medline: 15 4 2024
pubmed: 15 4 2024
entrez: 15 4 2024
Statut: epublish

Résumé

Spinocerebellar ataxia 21 (SCA21) is a rare neurological disorder caused by heterozygous variants in We describe two newly identified families harboring the recurrent pathogenic Adding to prior preliminary observations, our series highlights the relevance of hyperkinetic movements as clinically meaningful features of SCA21.

Sections du résumé

Background UNASSIGNED
Spinocerebellar ataxia 21 (SCA21) is a rare neurological disorder caused by heterozygous variants in
Case Series UNASSIGNED
We describe two newly identified families harboring the recurrent pathogenic
Discussion UNASSIGNED
Adding to prior preliminary observations, our series highlights the relevance of hyperkinetic movements as clinically meaningful features of SCA21.

Identifiants

pubmed: 38617829
doi: 10.5334/tohm.858
pmc: PMC11012930
doi:

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

16

Informations de copyright

Copyright: © 2024 The Author(s).

Déclaration de conflit d'intérêts

The authors have no competing interests to declare.

Auteurs

Ugo Sorrentino (U)

Clinical Genetics Unit, Department of Women's and Children's Health, University of Padova, Padova, Italy.
Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.
Institute of Human Genetics, Technical University of Munich, School of Medicine, Munich, Germany.

Luigi M Romito (LM)

Parkinson and Movement Disorders Unit, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Barbara Garavaglia (B)

Medical Genetics and Neurogenetics Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Mario Fichera (M)

Medical Genetics and Neurogenetics Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Isabel Colangelo (I)

Medical Genetics and Neurogenetics Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Holger Prokisch (H)

Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.
Institute of Human Genetics, Technical University of Munich, School of Medicine, Munich, Germany.

Juliane Winkelmann (J)

Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.
Institute of Human Genetics, Technical University of Munich, School of Medicine, Munich, Germany.
DZPG, Deutsches Zentrum für Psychische Gesundheit, Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Jan Necpal (J)

2nd Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Department of Neurology, Zvolen Hospital, Zvolen, Slovakia.

Robert Jech (R)

Department of Neurology and Centre of Clinical Neuroscience, General University Hospital and First Faculty of Medicine, Charles University, Kateřinská30, 12 800, Prague, Czech Republic.

Michael Zech (M)

Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.
Institute of Human Genetics, Technical University of Munich, School of Medicine, Munich, Germany.
Institute for Advanced Study, Technical University of Munich, Garching, Germany.

Classifications MeSH