Human skeletal muscle aging atlas.
Journal
Nature aging
ISSN: 2662-8465
Titre abrégé: Nat Aging
Pays: United States
ID NLM: 101773306
Informations de publication
Date de publication:
15 Apr 2024
15 Apr 2024
Historique:
received:
20
11
2023
accepted:
19
03
2024
medline:
16
4
2024
pubmed:
16
4
2024
entrez:
15
4
2024
Statut:
aheadofprint
Résumé
Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment. We found that distinct subsets of muscle stem cells exhibit decreased ribosome biogenesis genes and increased CCL2 expression, causing different aging phenotypes. Our atlas also highlights an expansion of nuclei associated with the neuromuscular junction, which may reflect re-innervation, and outlines how the loss of fast-twitch myofibers is mitigated through regeneration and upregulation of fast-type markers in slow-twitch myofibers with age. Furthermore, we document the function of aging muscle microenvironment in immune cell attraction. Overall, we present a comprehensive human skeletal muscle aging resource ( https://www.muscleageingcellatlas.org/ ) together with an in-house mouse muscle atlas to study common features of muscle aging across species.
Identifiants
pubmed: 38622407
doi: 10.1038/s43587-024-00613-3
pii: 10.1038/s43587-024-00613-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust (Wellcome)
ID : WT211276/Z/18/Z
Organisme : Wellcome Trust (Wellcome)
ID : WT206194
Organisme : Wellcome Trust (Wellcome)
ID : 220540/Z/20/A
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32000840
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31871370
Organisme : Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation)
ID : 2021A1515012065
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 101026233
Informations de copyright
© 2024. The Author(s).
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