CFP/Yit: An Inbred Mouse Strain with Slow Gastrointestinal Transit.

Cecal microbiota Fecal microbiota Fecal water content Feed intake Gastrointestinal transit time

Journal

Digestive diseases and sciences
ISSN: 1573-2568
Titre abrégé: Dig Dis Sci
Pays: United States
ID NLM: 7902782

Informations de publication

Date de publication:
15 Apr 2024
Historique:
received: 19 09 2023
accepted: 26 03 2024
medline: 16 4 2024
pubmed: 16 4 2024
entrez: 15 4 2024
Statut: aheadofprint

Résumé

Gastrointestinal transit (GIT) is influenced by factors including diet, medications, genetics, and gut microbiota, with slow GIT potentially indicating a functional disorder linked to conditions, such as constipation. Although GIT studies have utilized various animal models, few effectively model spontaneous slow GIT. We aimed to characterize the GIT phenotype of CFP/Yit (CFP), an inbred mouse strain with suggested slow GIT. Female and male CFP mice were compared to Crl:CD1 (ICR) mice in GIT and assessed based on oral gavage of fluorescent-labeled 70-kDa dextran, feed intake, fecal amount, and fecal water content. Histopathological analysis of the colon and analysis of gut microbiota were conducted. CFP mice exhibited a shorter small intestine and a 1.4-fold longer colon compared to ICR mice. The median whole-GIT time was 6.0-fold longer in CFP mice than in ICR mice. CFP mice demonstrated slower gastric and cecal transits than ICR mice, with a median colonic transit time of 4.1 h (2.9-fold longer). CFP mice exhibited lower daily feed intakes and fecal amounts. Fecal water content was lower in CFP mice, apparently attributed to the longer colon. Histopathological analysis showed no changes in CFP mice, including tumors or inflammation. Moreover, CFP mice had a higher Firmicutes/Bacteroidota ratio and a relative abundance of Erysipelotrichaceae in cecal and fecal contents. This study indicates that CFP mice exhibit slow transit in the stomach, cecum, and colon. As a novel mouse model, CFP mice can contribute to the study of gastrointestinal physiology and disease.

Sections du résumé

BACKGROUND BACKGROUND
Gastrointestinal transit (GIT) is influenced by factors including diet, medications, genetics, and gut microbiota, with slow GIT potentially indicating a functional disorder linked to conditions, such as constipation. Although GIT studies have utilized various animal models, few effectively model spontaneous slow GIT.
AIMS OBJECTIVE
We aimed to characterize the GIT phenotype of CFP/Yit (CFP), an inbred mouse strain with suggested slow GIT.
METHODS METHODS
Female and male CFP mice were compared to Crl:CD1 (ICR) mice in GIT and assessed based on oral gavage of fluorescent-labeled 70-kDa dextran, feed intake, fecal amount, and fecal water content. Histopathological analysis of the colon and analysis of gut microbiota were conducted.
RESULTS RESULTS
CFP mice exhibited a shorter small intestine and a 1.4-fold longer colon compared to ICR mice. The median whole-GIT time was 6.0-fold longer in CFP mice than in ICR mice. CFP mice demonstrated slower gastric and cecal transits than ICR mice, with a median colonic transit time of 4.1 h (2.9-fold longer). CFP mice exhibited lower daily feed intakes and fecal amounts. Fecal water content was lower in CFP mice, apparently attributed to the longer colon. Histopathological analysis showed no changes in CFP mice, including tumors or inflammation. Moreover, CFP mice had a higher Firmicutes/Bacteroidota ratio and a relative abundance of Erysipelotrichaceae in cecal and fecal contents.
CONCLUSIONS CONCLUSIONS
This study indicates that CFP mice exhibit slow transit in the stomach, cecum, and colon. As a novel mouse model, CFP mice can contribute to the study of gastrointestinal physiology and disease.

Identifiants

pubmed: 38622463
doi: 10.1007/s10620-024-08420-x
pii: 10.1007/s10620-024-08420-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Gaku Wagai (G)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan. gaku-wagai@yakult.co.jp.

Masao Togao (M)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.

Takashi Kurakawa (T)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.

Haruka Nishizaki (H)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.

Jun Otsuka (J)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.

Yuki Ohta-Takada (Y)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.

Akinobu Kurita (A)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.

Tomo Suzuki (T)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.

Koji Kawakami (K)

Yakult Central Institute, 5-11 Izumi, Kunitachi-Shi, Tokyo, 186-8650, Japan.

Classifications MeSH