Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results.
arterial spin labeling cerebral perfusion frontotemporal dementia presymptomatic biomarker

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
16 Apr 2024
Historique:
revised: 16 01 2024
received: 21 09 2023
accepted: 21 01 2024
medline: 16 4 2024
pubmed: 16 4 2024
entrez: 16 4 2024
Statut: aheadofprint

Résumé

Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers. We investigated longitudinal profiles of cerebral perfusion using arterial spin labeling magnetic resonance imaging in 42 C9orf72, 70 GRN, and 31 MAPT presymptomatic carriers and 158 non-carrier controls. Linear mixed effects models assessed perfusion up to 5 years after baseline assessment. Perfusion decline was evident in all three presymptomatic groups in global gray matter. Each group also featured its own regional pattern of hypoperfusion over time, with the left thalamus common to all groups. Frontal lobe regions featured lower perfusion in those who symptomatically converted versus asymptomatic carriers past their expected age of disease onset. Cerebral perfusion is a potential biomarker for assessing genetic FTD and its genetic subgroups prior to symptom onset. Gray matter perfusion declines in at-risk genetic frontotemporal dementia (FTD). Regional perfusion decline differs between at-risk genetic FTD subgroups . Hypoperfusion in the left thalamus is common across all presymptomatic groups. Converters exhibit greater right frontal hypoperfusion than non-converters past their expected conversion date. Cerebral hypoperfusion is a potential early biomarker of genetic FTD.

Identifiants

pubmed: 38623902
doi: 10.1002/alz.13750
doi:

Types de publication

English Abstract Journal Article

Langues

ita

Sous-ensembles de citation

IM

Subventions

Organisme : CIHR
ID : MOP-327387
Pays : Canada
Organisme : CIHR
ID : PJT-175242
Pays : Canada
Organisme : Medical Research Council
ID : MC_UU_00030/14
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T033371/1
Pays : United Kingdom

Informations de copyright

© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

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Auteurs

Maurice Pasternak (M)

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Saira S Mirza (SS)

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Nicholas Luciw (N)

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Henri J M M Mutsaerts (HJMM)

Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands.

Jan Petr (J)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany.

David Thomas (D)

Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

David Cash (D)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

Martina Bocchetta (M)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

Maria Carmela Tartaglia (MC)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Memory Clinic, University Health Network, Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Sara B Mitchell (SB)

Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Sandra E Black (SE)

Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Morris Freedman (M)

Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.

David Tang-Wai (D)

Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.
Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Ekaterina Rogaeva (E)

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

Lucy L Russell (LL)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

Arabella Bouzigues (A)

Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

John C van Swieten (JC)

Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.

Lize C Jiskoot (LC)

Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.

Harro Seelaar (H)

Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.

Robert Laforce (R)

Clinique Interdisciplinaire de Mémoire, CHU de Québec, Département des Sciences Neurologiques, Université Laval, Quebec, Quebec, Canada.

Pietro Tiraboschi (P)

Division of Neurology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Barbara Borroni (B)

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Daniela Galimberti (D)

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

James B Rowe (JB)

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

Caroline Graff (C)

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Unit for Hereditary Dementias, Karolinska University Hospital, Solna, Sweden.

Elizabeth Finger (E)

Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada.

Sandro Sorbi (S)

Department of Neurofarba, University of Florence, Florence, Italy.
Fondazione Don Carlo Gnocchi, Istituto di Ricovero e Cura a Carattere Scientifico, Florence, Italy.

Alexandre de Mendonça (A)

Neurology Department, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.

Chris Butler (C)

Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK.
Department of Brain Sciences, Imperial College London, London, UK.

Alex Gerhard (A)

Division of Psychology Communication and Human Neuroscience, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Department of Geriatric Medicine, Klinikum Hochsauerland GmbH, Arnsberg, Germany.
Department of Nuclear Medicine, Center for Translational Neuro- and Behavioral Sciences University Hospital Essen, Essen, Germany.

Raquel Sanchez-Valle (R)

Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic de Barcelona, Barcelona, Spain.

Fermin Moreno (F)

Cognitive Disorders Unit, Department of Neurology, Donostia University Hospital Gipuzkoa Building, Begiristain Doktorea Pasealekua, Donostia-San Sebastian, Gipuzkoa, Spain.
Neuroscience Area, Biodonostia Health Research Institute, Donostia-San Sebastian, Gipuzkoa, Spain.

Matthis Synofzik (M)

Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.

Rik Vandenberghe (R)

Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.

Simon Ducharme (S)

Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.
McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada.

Johannes Levin (J)

Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.

Markus Otto (M)

Department of Neurology, University of Ulm, Ulm, Germany.

Isabel Santana (I)

Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Antonio P Strafella (AP)

Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Edmond J. Safra Parkinson Disease Program & Morton and Gloria Shulman Movement Disorder Unit, Toronto Western Hospital UHN, Toronto, Ontario, Canada.

Bradley J MacIntosh (BJ)

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Jonathan D Rohrer (JD)

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

Mario Masellis (M)

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

Classifications MeSH