Corneal Neurotization for Neurotrophic Keratopathy: A Multicentre Experience.
Journal
Ophthalmic plastic and reconstructive surgery
ISSN: 1537-2677
Titre abrégé: Ophthalmic Plast Reconstr Surg
Pays: United States
ID NLM: 8508431
Informations de publication
Date de publication:
11 Apr 2024
11 Apr 2024
Historique:
medline:
16
4
2024
pubmed:
16
4
2024
entrez:
16
4
2024
Statut:
aheadofprint
Résumé
Corneal neurotization is an emerging technique that offers potential for visual rehabilitation in neurotrophic keratopathy. This study reports on a multicenter experience and outcomes for both direct and indirect methods of corneal neurotization. Retrospective case series. Sixteen patients with neurotrophic keratopathy who underwent corneal neurotization across 5 centers in Australia and Israel were identified for inclusion. Corneal neurotization was performed via direct neurotization from the ipsilateral or contralateral supraorbital/supratrochlear nerve or by the use of an interpositional sural nerve graft. Change in corneal sensitivity (measured in millimeters by the Cochet-Bonnet aesthesiometer), visual acuity, and corneal health. Over a mean follow-up period of 31.3 months (range: 3 months-8 years), mean corneal sensitivity improved from 3.6 mm (range: 0-25 mm) to 25.3 mm (range: 0-57 mm). Visual acuity improved on average from 20/380 to 20/260. Twelve of 16 patients (75.0%) improved in at least 2 out of the 3 main outcome measures. Nine patients (56.3%) showed an improvement in visual acuity; 13 (81.3%) showed an improvement in average corneal sensitivity; and 11 (68.8%) showed an improvement in corneal health. There were no intraoperative or postoperative complications. Corneal neurotization is an emerging surgical treatment option for the management of neurotrophic keratopathy. With appropriate case selection, outcomes are favorable and complication rates are low, for a condition that is otherwise challenging to manage. Patients with severe neurotrophic keratopathy should be considered for this surgical treatment option.
Identifiants
pubmed: 38624152
doi: 10.1097/IOP.0000000000002684
pii: 00002341-990000000-00376
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.
Déclaration de conflit d'intérêts
The authors have no financial or conflicts of interest to disclose.
Références
Malhotra R, Elalfy MS, Kannan R, et al. Update on corneal neurotisation. Br J Ophthalmol 2019;103:26–35.
Terzis JK, Dryer MM, Bodner BI. Corneal neurotization: a novel solution to neurotrophic keratopathy. Plast Reconstr Surg 2009;123:112–120.
Ting DSJ, Figueiredo GS, Henein C, et al. Corneal neurotization for neurotrophic keratopathy: clinical outcomes and in vivo confocal microscopic and histopathological findings. Cornea 2018;37:641–646.
Elbaz U, Bains R, Zuker RM, et al. Restoration of corneal sensation with regional nerve transfers and nerve grafts: a new approach to a difficult problem. JAMA Ophthalmol 2014;132:1289–1295.
Leyngold IM, Yen MT, Tian J, et al. Minimally invasive corneal neurotization with acellular nerve allograft: surgical technique and clinical outcomes. Ophthalmic Plast Reconstr Surg 2019;35:133–140.
Benkhatar H, Levy O, Goemaere I, et al. Corneal neurotization with a great auricular nerve graft: effective reinnervation demonstrated by in vivo confocal microscopy. Cornea 2018;37:647–650.
Jacinto F, Espana E, Padilla M, et al. Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: a novel surgical technique. Am J Ophthalmol Case Rep 2016;4:14–17.
Leyngold I, Weller C, Leyngold M, et al. Endoscopic corneal neurotization: technique and initial experience. Ophthalmic Plast Reconstr Surg 2018;34:82–85.
Wisely CE, Rafailov L, Cypen S, et al. Clinical and morphologic outcomes of minimally invasive direct corneal neurotization. Ophthalmic Plast Reconstr Surg 2020;36:451–457.
Gennaro P, Gabriele G, Aboh IV, et al. The second division of trigeminal nerve for corneal neurotization: a novel one-stage technique in combination with facial reanimation. J Craniofac Surg 2019;30:1252–1254.
Rafailov L, Kim JS, Wisely CE, et al. Clinical outcomes and patient satisfaction after corneal neurotization. Cornea 2021;40:1377–1386.
Domeshek LF, Hunter DA, Santosa K, et al. Anatomic characteristics of supraorbital and supratrochlear nerves relevant to their use in corneal neurotization. Eye (Lond) 2019;33:398–403.
Györi E, Tzou CH, Weninger WJ, et al. Axon numbers and landmarks of trigeminal donor nerves for corneal neurotization. PLoS One 2018;13:e0206642.
Weis E, Rubinov A, Al-Ghoul AR, et al. Sural nerve graft for neurotrophic keratitis: early results. Can J Ophthalmol 2018;53:24–29.
Sepehripour S, Lloyd MS, Nishikawa H, et al. Surrogate outcome measures for corneal neurotization in infants and children. J Craniofac Surg 2017;28:1167–1170.
Wu Y, Zhang J, Ding W, et al. Clinical outcomes of minimally invasive corneal neurotization after cerebellopontine angle neurosurgical procedures. Curr Eye Res 2022;47:670–676.
Catapano J, Fung SSM, Halliday W, et al. Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation. Br J Ophthalmol 2019;103:1724–1731.
Charlson ES, Pepper JP, Kossler AL. Corneal neurotization via dual nerve autografting. Ophthalmic Plast Reconstr Surg 2022;38:e17–e19.
Woo JH, Daeschler SC, Mireskandari K, et al. Minimally invasive corneal neurotization provides sensory function, protects against recurrent ulceration, and improves visual acuity. Am J Ophthalmol 2022;241:179–189.
Jowett N, Pineda Ii R. Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy. Br J Ophthalmol 2019;103:1235–1238.
Lau N, Osborne SF, Vasquez-Perez A, et al. Corneal neurotization using the great auricular nerve for bilateral congenital trigeminal anesthesia. Cornea 2022;41:654–657.
Fogagnolo P, Giannaccare G, Bolognesi F, et al. Direct versus indirect corneal neurotization for the treatment of neurotrophic keratopathy: a multicenter prospective comparative study. Am J Ophthalmol 2020;220:203–214.
Park JK, Charlson ES, Leyngold I, et al. Corneal neurotization: a review of pathophysiology and outcomes. Ophthalmic Plast Reconstr Surg 2020;36:431–437.
Swanson MA, Swanson RD, Kotha VS, et al. Corneal neurotization: a meta-analysis of outcomes and patient selection factors. Ann Plast Surg 2022;88:687–694.
Elalfy M, Maqsood S, Hau S, et al. Functional and structural changes following corneal neurotisation in the management of neurotrophic keratopathy: UK single centre series. Clin Ophthalmol 2021;15:2149–2160.
Safa B, Jain S, Desai MJ, et al. Peripheral nerve repair throughout the body with processed nerve allografts: results from a large multicenter study. Microsurgery 2020;40:527–537.
Sweeney AR, Wang M, Weller CL, et al. Outcomes of corneal neurotisation using processed nerve allografts: a multicentre case series. Br J Ophthalmol 2022;106:326–330.