Machine learning approach to assess the association between anthropometric, metabolic, and nutritional status and semen parameters.
Journal
Asian journal of andrology
ISSN: 1745-7262
Titre abrégé: Asian J Androl
Pays: China
ID NLM: 100942132
Informations de publication
Date de publication:
12 Apr 2024
12 Apr 2024
Historique:
received:
12
12
2023
accepted:
29
01
2024
medline:
16
4
2024
pubmed:
16
4
2024
entrez:
16
4
2024
Statut:
aheadofprint
Résumé
Many lifestyle factors, such as nutritional imbalance leading to obesity, metabolic disorders, and nutritional deficiency, have been identified as potential risk factors for male infertility. The aim of this study was to evaluate the relationship between semen parameters and anthropometric, metabolic and nutritional parameters. Relationship was first assessed individually, then after the application of a previously constructed and validated machine learning score that allows their combination. Anthropometric, metabolic, antioxidant, micronutrient, and sperm parameters from 75 men suffering from idiopathic infertility from four infertility centers in France (Jean-Verdier ART Center Hospital, Bondy; North Hospital ART Center, Saint-Étienne; Navarre Polyclinic ART Center, Pau; and Cochin Hospital ART Center, Paris) between September 2009 and December 2013 were collected. After assessing standard correlation analysis, a previously built machine learning model, providing a score ranging from 0 (the poorest) to 1 (the most favorable), was calculated for each man in the study cohort. This machine learning model, which separates infertile/fertile men with unexplained infertility on the basis of their bioclinical signature, provides a more holistic evaluation of the influence of the considered markers (anthropometric, metabolic, and oxidative status). We observed a significant correlation of some anthropometric, metabolic, and nutritional disorders with some sperm characteristics. Moreover, an unfavorable machine learning score was associated with a high level of sperm DNA fragmentation. Favorable anthropometric, metabolic, and oxidative patterns, which may reflect an appropriate lifestyle, appear to positively impact overall health, in particular reproductive function. This study, consistent with previous publications, suggests that beyond semen quality parameters, in an essential assessment of male fertility, other key factors should be taken into account. In this regard, the application of emerging artificial intelligence techniques may provide a unique opportunity to integrate all these parameters and deliver personalized care.
Identifiants
pubmed: 38624205
doi: 10.4103/aja20247
pii: 00129336-990000000-00174
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Copyright: © 2024 The Author(s)(2024).
Références
Levine H, Jørgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, et al. Temporal trends in sperm count:a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Hum Reprod Update 2023;29:157–76.
Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, et al. BMI in relation to sperm count:an updated systematic review and collaborative meta-analysis. Hum Reprod Update 2013;19:221–31.
Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, Sørensen TI, et al. Subfecundity in overweight and obese couples. Hum Reprod 2007;22:1634–7.
Esmaeili V, Zendehdel M, Shahverdi A, Alizadeh A. Relationship between obesity-related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic. Andrologia 2022;54:e14524.
Dupont C, Faure C, Sermondade N, Boubaya M, Eustache F, et al. Obesity leads to higher risk of sperm DNA damage in infertile patients. Asian J Androl 2013;15:622–5.
Leisegang K, Sengupta P, Agarwal A, Henkel R. Obesity and male infertility:mechanisms and management. Andrologia 2021;53:e13617.
Sun B, Messerlian C, Sun ZH, Duan P, Chen HG, et al. Physical activity and sedentary time in relation to semen quality in healthy men screened as potential sperm donors. Hum Reprod 2019;34:2330–9.
Dupont C, Faure C, Daoud F, Gautier B, Czernichow S, et al. Metabolic syndrome and smoking are independent risk factors of male idiopathic infertility. Basic Clin Androl 2019;29:9.
Foucaut AM, Faure C, Julia C, Czernichow S, Levy R, et al. Sedentary behavior, physical inactivity and body composition in relation to idiopathic infertility among men and women. PLoS One 2019;14:e0210770.
Bachelot G, Lévy R, Bachelot A, Faure C, Czernichow S, et al. Proof of concept and development of a couple-based machine learning model to stratify infertile patients with idiopathic infertility. Sci Rep 2021;11:24003.
Hammiche F, Laven JS, Twigt JM, Boellaard WP, Steegers EA, et al. Body mass index and central adiposity are associated with sperm quality in men of subfertile couples. Hum Reprod 2012;27:2365–72.
Carrageta DF, Oliveira PF, Alves MG, Monteiro MP. Obesity and male hypogonadism:tales of a vicious cycle. Obes Rev 2019;20:1148–58.
Hautanen A. Synthesis and regulation of sex hormone-binding globulin in obesity. Int J Obes 2000;24 Suppl 2:S64–70.
Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm 2010;2010:289645.
Fève B, Bastard JP, Vidal H. [Relationship between obesity, inflammation and insulin resistance:new concepts. C R Biol 2006;329:587–97. [Article in French].
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004;114:1752–61.
Vincent HK, Innes KE, Vincent KR. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab 2007;9:813–39.
Baccetti B. Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality. Hum Reprod 2002;17:2673–7.
Yu T, Robotham JL, Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 2006;103:2653–8.
Shi GJ, Li Y, Cao QH, Wu HX, Tang XY, et al. In vitro and in vivo evidence that quercetin protects against diabetes and its complications:a systematic review of the literature. Biomed Pharmacother 2019;109:1085–99.
Esteves SC. Interventions to prevent sperm DNA damage effects on reproduction. Adv Exp Med Biol 2019;1166:119–48.
McQueen DB, Zhang J, Robins JC. Sperm DNA fragmentation and recurrent pregnancy loss:a systematic review and meta-analysis. Fertil Steril 2019;112:54–60.e3.
World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen. 5th ed. Geneva: World Health Organization; 2010.
Auger J, Eustache F, Andersen AG, Irvine DS, Jørgensen N, et al. Sperm morphological defects related to environment, lifestyle and medical history of 1001 male partners of pregnant women from four European cities. Hum Reprod 2001;16:2710–7.
Jouannet P, Ducot B, Feneux D, Spira A. Male factors and the likelihood of pregnancy in infertile couples. I. Study of sperm characteristics. Int J Androl 1988;11:379–4.
Haddock L, Gordon S, Lewis SE, Larsen P, Shehata A, et al. Sperm DNA fragmentation is a novel biomarker for early pregnancy loss. Reprod Biomed Online 2021;42:175–84.
Sermondade N. Obesity and increased risk for oligozoospermia and azoospermia. Arch Intern Med 2012;172:440.
Kort HI. Impact of body mass index values on sperm quantity and quality. J Androl 2006;27:450–2.
Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 2010;93:2222–31.
Belloc S, Cohen-Bacrie M, Amar E, Izard V, Benkhalifa M, et al. High body mass index has a deleterious effect on semen parameters except morphology:results from a large cohort study. Fertil Steril 2014;102:1268–73.
Sekhavat L, Moein MR. The effect of male body mass index on sperm parameters. Aging Male 2010;13:155–8.
Pushpendra A, Gc J. Hyper-lipidemia and male fertility:a critical review of literature. Andrology 2015;4:141.
Martínez-Martos JM, Arrazola M, Mayas MD, Carrera-González MP, García MJ, et al. Diet-induced hypercholesterolemia impaired testicular steroidogenesis in mice through the renin–angiotensin system. Gen Comp Endocrinol 2011;173:15–9.
Ouvrier A, Alves G, Damon-Soubeyrand C, Marceau G, Cadet R, et al. Dietary cholesterol-induced post-testicular infertility. PLoS One 2011;6:e26966.
Selley ML, Lacey MJ, Bartlett MR, Copeland CM, Ardlie NG. Content of significant amounts of a cytotoxic end-product of lipid peroxidation in human semen. Reproduction 1991;92:291–8.
Banihani SA. Vitamin B12 and semen quality. Biomolecules 2017;7:42.
Boxmeer JC, Smit M, Weber RF, Lindemans J, Romijn JC, et al. Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures. J Androl 2007;28:521–7.
Dhillon VS, Shahid M, Husain SA. Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men. MHR Basic Sci Reprod Med 2007;13:213–22.
Hu JH, Tian WQ, Zhao XL, Zan LS, Xin YP, et al. The cryoprotective effects of Vitamin B12 supplementation on bovine semen quality:effects of Vitamin B12 on bovine semen quality. Reprod Domest Anim 2011;46:66–73.
Imai H, Suzuki K, Ishizaka K, Ichinose S, Oshima H, et al. Failure of the expression of phospholipid hydroperoxide glutathione peroxidase in the spermatozoa of human infertile males. Biol Reprod 2001;64:674–83.
Kralikova M, Crha I, Huser M, Melounova J, Zakova J, et al. The intracellular concentration of homocysteine and related thiols is negatively correlated to sperm quality after highly effective method of sperm lysis. Andrologia 2017;49:e12702.
Giannattasio A, De Rosa M, Smeraglia R, Zarrilli S, Cimmino A, et al. Glutathione peroxidase (GPX) activity in seminal plasma of healthy and infertile males. J Endocrinol Invest 2002;25:983–6.
Crisol L, Matorras R, Aspichueta F, Expósito A, Hernández ML, et al. Glutathione peroxidase activity in seminal plasma and its relationship to classical sperm parameters and in vitro fertilization-intracytoplasmic sperm injection outcome. Fertil Steril 2012;97:852–7.e1.
Drevet JR. The antioxidant glutathione peroxidase family and spermatozoa:a complex story. Mol Cell Endocrinol 2006;250:70–9.
Minhas S, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, et al. European association of urology guidelines on male sexual and reproductive health:2021 Update on Male Infertility. Eur Urol 2021;80:603–20.
Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, et al. Diagnosis and treatment of infertility in men:AUA/ASRM Guideline Part I. J Urol 2021;205:36–43.
Schlegel PN, Sigman M, Collura B, De Jonge CJ, Eisenberg ML, et al. Diagnosis and treatment of infertility in men:AUA/ASRM guideline part II. Fertil Steril 2021;115:62–9.
Dupont C, Aegerter P, Foucaut AM, Reyre A, Lhuissier FJ, et al. Effectiveness of a therapeutic multiple-lifestyle intervention taking into account the periconceptional environment in the management of infertile couples:study design of a randomized controlled trial –The PEPCI study. BMC Pregnancy Childbirth 2020;20:322.