European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children.
Adolescents
Children
Insomnia
Melatonin
Pediatricians
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
16 Apr 2024
16 Apr 2024
Historique:
received:
10
01
2024
accepted:
03
04
2024
revised:
02
04
2024
medline:
16
4
2024
pubmed:
16
4
2024
entrez:
16
4
2024
Statut:
aheadofprint
Résumé
Sleeping problems are prevalent among children and adolescents, often leading to frequent consultations with pediatricians. While cognitive-behavioral therapy has shown effectiveness, especially in the short term, there is a lack of globally endorsed guidelines for the use of pharmaceuticals or over-the-counter remedies in managing sleep onset insomnia. An expert panel of pediatric sleep specialists and chronobiologists met in October 2023 to develop practical recommendations for pediatricians on the management of sleep onset insomnia in typically developing children. When sleep onset insomnia is present in otherwise healthy children, the management should follow a stepwise approach. Practical sleep hygiene indications and adaptive bedtime routine, followed by behavioral therapies, must be the first step. When these measures are not effective, low-dose melatonin, administered 30-60 min before bedtime, might be helpful in children over 2 years old. Melatonin use should be monitored by pediatricians to evaluate the efficacy as well as the presence of adverse effects. Conclusion: Low-dose melatonin is a useful strategy for managing sleep onset insomnia in healthy children who have not improved or have responded insufficiently to sleep hygiene and behavioral interventions.
Identifiants
pubmed: 38625388
doi: 10.1007/s00431-024-05556-w
pii: 10.1007/s00431-024-05556-w
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Glaze DG, Rosen CL, Owens JA (2002) Toward a practical definition of pediatric insomnia. Curr Ther Res 63:B4–B17. https://doi.org/10.1016/S0011-393X(02)80100-X
doi: 10.1016/S0011-393X(02)80100-X
Meaklim H, Jackson ML, Bartlett D, Saini B, Falloon K, Junge M, Slater J, Rehm IC, Meltzer LJ (2020) Sleep education for healthcare providers: addressing deficient sleep in Australia and New Zealand. Sleep Health 6:636–650. https://doi.org/10.1016/j.sleh.2020.01.012
doi: 10.1016/j.sleh.2020.01.012
pubmed: 32423774
Corkum P, Weiss S, Hall W, Brown C, Chambers C, Constantin E, Godbout R, Hanlon-Dearman A, Ipsiroglu O, Reid GJ, Shea S, Smith IM, Stremler R, Witmans M (2019) Assessment and treatment of pediatric behavioral sleep disorders in Canada. Sleep Med 56:29–37. https://doi.org/10.1016/j.sleep.2018.11.007
doi: 10.1016/j.sleep.2018.11.007
pubmed: 30555028
American Academy of Sleep Medicine (2014) International classification of sleep Disorders: Diagnostic and coding manual, 3rd edn. American Academy of Sleep Medicine, Darien, IL
Breda M, Belli A, Esposito D, Di Pilla A, Melegari MG, DelRosso L, Malorgio E, Doria M, Ferri R, Bruni O (2023) Sleep habits and sleep disorders in Italian children and adolescents: a cross-sectional survey. J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med. https://doi.org/10.5664/jcsm.10400
doi: 10.5664/jcsm.10400
Lewien C, Genuneit J, Meigen C, Kiess W, Poulain T (2021) Sleep-related difficulties in healthy children and adolescents. BMC Pediatr 21:82. https://doi.org/10.1186/s12887-021-02529-y
doi: 10.1186/s12887-021-02529-y
pubmed: 33593333
pmcid: 7885393
Fadzil A (2021) Factors affecting the quality of sleep in children. Child Basel Switz 8:122. https://doi.org/10.3390/children8020122
doi: 10.3390/children8020122
Dewald JF, Meijer AM, Oort FJ, Kerkhof GA, Bögels SM (2010) The influence of sleep quality, sleep duration and sleepiness on school performance in children and adolescents: a meta-analytic review. Sleep Med Rev 14:179–189. https://doi.org/10.1016/j.smrv.2009.10.004
doi: 10.1016/j.smrv.2009.10.004
pubmed: 20093054
Blunden S, Galland B (2014) The complexities of defining optimal sleep: empirical and theoretical considerations with a special emphasis on children. Sleep Med Rev 18:371–378. https://doi.org/10.1016/j.smrv.2014.01.002
doi: 10.1016/j.smrv.2014.01.002
pubmed: 24629828
Phillips SR, Johnson A, Shirey MR, Rice M (2020) Sleep quality in school-aged children: a concept analysis. J Pediatr Nurs 52:54–63. https://doi.org/10.1016/j.pedn.2020.02.043
doi: 10.1016/j.pedn.2020.02.043
pubmed: 32179378
pmcid: 7285623
Hirshkowitz M, Whiton K, Albert SM, Alessi C, Bruni O, DonCarlos L, Hazen N, Herman J, Katz ES, Kheirandish-Gozal L, Neubauer DN, O’Donnell AE, Ohayon M, Peever J, Rawding R, Sachdeva RC, Setters B, Vitiello MV, Ware JC, Hillard PJA (2015) National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health J Natl Sleep Found 1:40–43. https://doi.org/10.1016/j.sleh.2014.12.010
doi: 10.1016/j.sleh.2014.12.010
Taylor RW, Haszard JJ, Jackson R, Morrison S, Beebe DW, Meredith-Jones KA, Elder DE, Galland BC (2023) Effect of sleep changes on health-related quality of life in healthy children: a secondary analysis of the DREAM crossover trial. JAMA Netw Open 6:e233005. https://doi.org/10.1001/jamanetworkopen.2023.3005
doi: 10.1001/jamanetworkopen.2023.3005
pubmed: 36920394
pmcid: 10018327
Sadeh A, Gruber R, Raviv A (2003) The effects of sleep restriction and extension on school-age children: what a difference an hour makes. Child Dev 74:444–455. https://doi.org/10.1111/1467-8624.7402008
doi: 10.1111/1467-8624.7402008
pubmed: 12705565
Krause AJ, Ben Simon E, Mander BA, Greer SM, Saletin JM, Goldstein-Piekarski AN, Walker MP (2017) The sleep-deprived human brain. Nat Rev Neurosci 18:404–418. https://doi.org/10.1038/nrn.2017.55
doi: 10.1038/nrn.2017.55
pubmed: 28515433
pmcid: 6143346
Armstrong JM, Ruttle PL, Klein MH, Essex MJ, Benca RM (2014) Associations of child insomnia, sleep movement, and their persistence with mental health symptoms in childhood and adolescence. Sleep 37:901–909. https://doi.org/10.5665/sleep.3656
doi: 10.5665/sleep.3656
pubmed: 24790268
pmcid: 3985117
Fernandez-Mendoza J, Bourchtein E, Calhoun S, Puzino K, Snyder CK, He F, Vgontzas AN, Liao D, Bixler E (2021) Natural history of insomnia symptoms in the transition from childhood to adolescence: population rates, health disparities, and risk factors. Sleep 44:zsaa187. https://doi.org/10.1093/sleep/zsaa187
doi: 10.1093/sleep/zsaa187
pubmed: 32929504
Bruni O, Melegari MG, Esposito A, Sette S, Angriman M, Apicella M, Caravale B, Ferri R (2020) Executive functions in preschool children with chronic insomnia. J Clin Sleep Med 16:231–241. https://doi.org/10.5664/JCSM.8172
doi: 10.5664/JCSM.8172
pubmed: 31992417
pmcid: 7053020
Dahl RE (1996) The impact of inadequate sleep on children’s daytime cognitive function. Semin Pediatr Neurol 3:44–50. https://doi.org/10.1016/s1071-9091(96)80028-3
doi: 10.1016/s1071-9091(96)80028-3
pubmed: 8795841
Yoo S-S, Gujar N, Hu P, Jolesz FA, Walker MP (2007) The human emotional brain without sleep–a prefrontal amygdala disconnect. Curr Biol CB 17:R877-878. https://doi.org/10.1016/j.cub.2007.08.007
doi: 10.1016/j.cub.2007.08.007
pubmed: 17956744
Shimizu M, Zeringue MM, Erath SA, Hinnant JB, El-Sheikh M (2021) Trajectories of sleep problems in childhood: associations with mental health in adolescence. Sleep 44:zsaa190. https://doi.org/10.1093/sleep/zsaa190
doi: 10.1093/sleep/zsaa190
pubmed: 33001174
Yang FN, Xie W, Wang Z (2022) Effects of sleep duration on neurocognitive development in early adolescents in the USA: a propensity score matched, longitudinal, observational study. Lancet Child Adolesc Health 6:705–712. https://doi.org/10.1016/S2352-4642(22)00188-2
doi: 10.1016/S2352-4642(22)00188-2
pubmed: 35914537
Uccella S, Cordani R, Salfi F, Gorgoni M, Scarpelli S, Gemignani A, Geoffroy PA, De Gennaro L, Palagini L, Ferrara M, Nobili L (2023) Sleep deprivation and insomnia in adolescence: implications for mental health. Brain Sci 13:569. https://doi.org/10.3390/brainsci13040569
doi: 10.3390/brainsci13040569
pubmed: 37190534
pmcid: 10136689
Zhou J, Zhu L, Teng Y, Tong J, Gao G, Yan S, Tao F, Huang K (2023) Early sleep duration trajectories and children’s cognitive development: a prospective cohort study. Eur J Pediatr 182:5353–5365. https://doi.org/10.1007/s00431-023-05195-7
doi: 10.1007/s00431-023-05195-7
pubmed: 37737885
Meininger JC, Gallagher MR, Eissa MA, Nguyen TQ, Chan W (2014) Sleep duration and its association with ambulatory blood pressure in a school-based, diverse sample of adolescents. Am J Hypertens 27:948–955. https://doi.org/10.1093/ajh/hpt297
doi: 10.1093/ajh/hpt297
pubmed: 24487981
pmcid: 4118569
Javaheri S, Storfer-Isser A, Rosen CL, Redline S (2011) The association of short and long sleep durations with insulin sensitivity in adolescents. J Pediatr 158:617–623. https://doi.org/10.1016/j.jpeds.2010.09.080
doi: 10.1016/j.jpeds.2010.09.080
pubmed: 21146189
Sunwoo J-S, Yang KI, Kim JH, Koo DL, Kim D, Hong SB (2020) Sleep duration rather than sleep timing is associated with obesity in adolescents. Sleep Med 68:184–189. https://doi.org/10.1016/j.sleep.2019.12.014
doi: 10.1016/j.sleep.2019.12.014
pubmed: 32044556
Sehn AP, Gaya AR, Dias AF, Brand C, Mota J, Pfeiffer KA, Sayavera JB, Renner JDP, Reuter CP (2020) Relationship between sleep duration and TV time with cardiometabolic risk in adolescents. Environ Health Prev Med 25:42. https://doi.org/10.1186/s12199-020-00880-7
doi: 10.1186/s12199-020-00880-7
pubmed: 32825824
pmcid: 7442988
Tambalis KD, Panagiotakos DB, Psarra G, Sidossis LS (2018) Insufficient sleep duration is associated with dietary habits, screen time, and obesity in children. J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med 14:1689–1696. https://doi.org/10.5664/jcsm.7374
doi: 10.5664/jcsm.7374
Cappuccio FP, Taggart FM, Kandala N-B, Currie A, Peile E, Stranges S, Miller MA (2008) Meta-analysis of short sleep duration and obesity in children and adults. Sleep 31:619–626. https://doi.org/10.1093/sleep/31.5.619
doi: 10.1093/sleep/31.5.619
pubmed: 18517032
pmcid: 2398753
Yuwen W, Chen ML, Cain KC, Ringold S, Wallace CA, Ward TM (2016) Daily sleep patterns, sleep quality, and sleep hygiene among parent-child dyads of young children newly diagnosed with juvenile idiopathic arthritis and typically developing children. J Pediatr Psychol 41:651–660. https://doi.org/10.1093/jpepsy/jsw007
doi: 10.1093/jpepsy/jsw007
pubmed: 26994855
pmcid: 5009455
Dubois-Comtois K, Pennestri M-H, Bernier A, Cyr C, Godbout R (2019) Family environment and preschoolers’ sleep: the complementary role of both parents. Sleep Med 58:114–122. https://doi.org/10.1016/j.sleep.2019.03.002
doi: 10.1016/j.sleep.2019.03.002
pubmed: 31146123
Merrill RM, Slavik KR (2023) Relating parental stress with sleep disorders in parents and children. PLoS ONE 18:e0279476. https://doi.org/10.1371/journal.pone.0279476
doi: 10.1371/journal.pone.0279476
pubmed: 36696403
pmcid: 9876271
Bayer JK, Hiscock H, Hampton A, Wake M (2007) Sleep problems in young infants and maternal mental and physical health. J Paediatr Child Health 43:66–73. https://doi.org/10.1111/j.1440-1754.2007.01005.x
doi: 10.1111/j.1440-1754.2007.01005.x
pubmed: 17207059
Mansolf M, Blackwell CK, Chandran A, Colicino E, Geiger S, Harold G, McEvoy C, Santos HP, Sherlock PR, Bose S, Wright RJ (2023) Caregiver perceived stress and child sleep health: an item-level individual participant data meta-analysis. J Child Fam Stud 32:2558–2572. https://doi.org/10.1007/s10826-023-02624-x
doi: 10.1007/s10826-023-02624-x
pubmed: 37662702
Martin J, Hiscock H, Hardy P, Davey B, Wake M (2007) Adverse associations of infant and child sleep problems and parent health: an Australian population study. Pediatrics 119:947–955. https://doi.org/10.1542/peds.2006-2569
doi: 10.1542/peds.2006-2569
pubmed: 17473096
Meltzer LJ, Mindell JA (2007) Relationship between child sleep disturbances and maternal sleep, mood, and parenting stress: a pilot study. J Fam Psychol JFP J Div Fam Psychol Am Psychol Assoc Div 43(21):67–73. https://doi.org/10.1037/0893-3200.21.1.67
doi: 10.1037/0893-3200.21.1.67
Kelly RJ, El-Sheikh M (2011) Marital conflict and children’s sleep: reciprocal relations and socioeconomic effects. J Fam Psychol JFP J Div Fam Psychol Am Psychol Assoc Div 43(25):412–422. https://doi.org/10.1037/a0023789
doi: 10.1037/a0023789
Maratia F, Bacaro V, Crocetti E (2023) Sleep is a family affair: a systematic review and meta-analysis of longitudinal studies on the interplay between adolescents’ sleep and family factors. Int J Environ Res Public Health 20:4572. https://doi.org/10.3390/ijerph20054572
doi: 10.3390/ijerph20054572
pubmed: 36901581
pmcid: 10001512
Dewald-Kaufmann J, de Bruin E, Michael G (2019) Cognitive behavioral therapy for insomnia (CBT-i) in school-aged children and adolescents. Sleep Med Clin 14:155–165. https://doi.org/10.1016/j.jsmc.2019.02.002
doi: 10.1016/j.jsmc.2019.02.002
pubmed: 31029183
Williamson AA, Mindell JA, Hiscock H, Quach J (2019) Child sleep behaviors and sleep problems from infancy to school-age. Sleep Med 63:5–8. https://doi.org/10.1016/j.sleep.2019.05.003
doi: 10.1016/j.sleep.2019.05.003
pubmed: 31600659
pmcid: 6859188
Simonneaux V, Ribelayga C (2003) Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 55:325–395. https://doi.org/10.1124/pr.55.2.2
doi: 10.1124/pr.55.2.2
pubmed: 12773631
Prayag AS, Münch M, Aeschbach D, Chellappa SL, Gronfier C (2019) Light modulation of human clocks, wake, and sleep. Clocks Sleep 1:193–208. https://doi.org/10.3390/clockssleep1010017
doi: 10.3390/clockssleep1010017
pubmed: 32342043
pmcid: 7185269
Prayag AS, Najjar RP, Gronfier C (2019) Melatonin suppression is exquisitely sensitive to light and primarily driven by melanopsin in humans. J Pineal Res 66:e12562. https://doi.org/10.1111/jpi.12562
doi: 10.1111/jpi.12562
pubmed: 30697806
Mauriz JL, Collado PS, Veneroso C, Reiter RJ, González-Gallego J (2013) A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives. J Pineal Res 54:1–14. https://doi.org/10.1111/j.1600-079X.2012.01014.x
doi: 10.1111/j.1600-079X.2012.01014.x
pubmed: 22725668
Comai S, Ochoa-Sanchez R, Gobbi G (2013) Sleep-wake characterization of double MT1/MT2 receptor knockout mice and comparison with MT1 and MT2 receptor knockout mice. Behav Brain Res 243:231–238. https://doi.org/10.1016/j.bbr.2013.01.008
doi: 10.1016/j.bbr.2013.01.008
pubmed: 23333399
Skrzelowski M, Brookhaus A, Shea LA, Berlau DJ (2021) Melatonin use in pediatrics: evaluating the discrepancy in evidence based on country and regulations regarding production. J Pediatr Pharmacol Ther JPPT Off J PPAG 26:4–20. https://doi.org/10.5863/1551-6776-26.1.4
doi: 10.5863/1551-6776-26.1.4
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2011) Scientific opinion on the substantiation of a health claim related to melatonin and reduction of sleep onset latency (ID 1698, 1780, 4080) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J 9:2241. https://doi.org/10.2903/j.efsa.2011.2241
doi: 10.2903/j.efsa.2011.2241
Black LI, Clarke TC, Barnes PM, Stussman BJ, Nahin RL (2015) Use of complementary health approaches among children aged 4–17 years in the United States: National Health Interview Survey, 2007–2012. Natl Health Stat Rep 78:1–19
Lee SKM, Smith L, Tan ECK, Cairns R, Grunstein R, Cheung JMY (2023) Melatonin use in children and adolescents: a scoping review of caregiver perspectives. Sleep Med Rev 70:101808. https://doi.org/10.1016/j.smrv.2023.101808
doi: 10.1016/j.smrv.2023.101808
pubmed: 37451058
Parvataneni T, Srinivas S, Shah K, Patel RS (2020) Perspective on melatonin use for sleep problems in autism and attention-deficit hyperactivity disorder: a systematic review of randomized clinical trials. Cureus 12:e8335. https://doi.org/10.7759/cureus.8335
doi: 10.7759/cureus.8335
pubmed: 32617211
pmcid: 7325410
Rzepka-Migut B, Paprocka J (2020) Efficacy and safety of melatonin treatment in children with autism spectrum disorder and attention-deficit/hyperactivity disorder—a review of the literature. Brain Sci 10:219. https://doi.org/10.3390/brainsci10040219
doi: 10.3390/brainsci10040219
pubmed: 32272607
pmcid: 7226342
Edemann-Callesen H, Andersen HK, Ussing A, Virring A, Jennum P, Debes NM, Laursen T, Baandrup L, Gade C, Dettmann J, Holm J, Krogh C, Birkefoss K, Tarp S, Händel MN (2023) Use of melatonin in children and adolescents with idiopathic chronic insomnia: a systematic review, meta-analysis, and clinical recommendation. eClinicalMedicine 61:102048. https://doi.org/10.1016/j.eclinm.2023.102048
doi: 10.1016/j.eclinm.2023.102048
pubmed: 37457117
pmcid: 10339205
Händel MN, Andersen HK, Ussing A, Virring A, Jennum P, Debes NM, Laursen T, Baandrup L, Gade C, Dettmann J, Holm J, Krogh C, Birkefoss K, Tarp S, Bliddal M, Edemann-Callesen H (2023) The short-term and long-term adverse effects of melatonin treatment in children and adolescents: a systematic review and GRADE assessment. eClinicalMedicine 61:102083. https://doi.org/10.1016/j.eclinm.2023.102083
doi: 10.1016/j.eclinm.2023.102083
pubmed: 37483551
pmcid: 10359736
Choi K, Lee YJ, Park S, Je NK, Suh HS (2022) Efficacy of melatonin for chronic insomnia: systematic reviews and meta-analyses. Sleep Med Rev 66:101692. https://doi.org/10.1016/j.smrv.2022.101692
doi: 10.1016/j.smrv.2022.101692
pubmed: 36179487
Goldman RD, Bongiorno PB, Olcese JM, Witt-Enderby PA, Shatkin JP (2021) Myths and evidence regarding melatonin supplementation for occasional sleeplessness in the pediatric population. Pediatr Ann 50:e391–e395. https://doi.org/10.3928/19382359-20210823-01
doi: 10.3928/19382359-20210823-01
pubmed: 34542334
Pin Arboledas G, Merino Andreu M, de la Calle CT, Hidalgo Vicario MI, Rodríguez Hernández PJ, Soto Insuga V (2003) Madrid Pérez JA (2014) [Consensus document on the clinical use of melatonin in children and adolescents with sleep-onset insomnia]. An Pediatr Barc Spain 81(328):e1-9. https://doi.org/10.1016/j.anpedi.2014.03.011
doi: 10.1016/j.anpedi.2014.03.011
Bruni O, Alonso-Alconada D, Besag F, Biran V, Braam W, Cortese S, Moavero R, Parisi P, Smits M, Van der Heijden K, Curatolo P (2015) Current role of melatonin in pediatric neurology: clinical recommendations. Eur J Paediatr Neurol EJPN Off J Eur Paediatr Neurol Soc 19:122–133. https://doi.org/10.1016/j.ejpn.2014.12.007
doi: 10.1016/j.ejpn.2014.12.007
Hagan JS, Duncan P, Shaw JS (2008) Bright futures: guidelines for health supervision of infants, children, and adolescents, Third Edition. Pocket Guide. American Academy of Pediatrics, Elk Grove Village, IL
Wilson K, St-Onge M-P, Tasali E (2022) Diet composition and objectively assessed sleep quality: a narrative review. J Acad Nutr Diet 122:1182–1195. https://doi.org/10.1016/j.jand.2022.01.007
doi: 10.1016/j.jand.2022.01.007
pubmed: 35063665
pmcid: 9124688
Ríos-Hernández A, Gilchrist C, Chelimo C, Castro TG, Izquierdo-Pulido M, Wall C, Thabrew H, Berry S, Morton S, Grant C (2022) The relationship between diet and sleep in 2-y-old children: results from growing up in New Zealand. Nutrition 95:111560. https://doi.org/10.1016/j.nut.2021.111560
doi: 10.1016/j.nut.2021.111560
pubmed: 35033740
Faris ME, Vitiello MV, Abdelrahim DN, Cheikh Ismail L, Jahrami HA, Khaleel S, Khan MS, Shakir AZ, Yusuf AM, Masaad AA, Bahammam AS (2022) Eating habits are associated with subjective sleep quality outcomes among university students: findings of a cross-sectional study. Sleep Breath 26:1365–1376. https://doi.org/10.1007/s11325-021-02506-w
doi: 10.1007/s11325-021-02506-w
pubmed: 34613509
Zhao Y, Qu D, Liang K, Bao R, Chen S (2023) Eating habits matter for sleep difficulties in children and adolescents: a cross-sectional study. Front Pediatr 11:1108031. https://doi.org/10.3389/fped.2023.1108031
doi: 10.3389/fped.2023.1108031
pubmed: 37377761
pmcid: 10292748
Mindell JA, Williamson AA (2018) Benefits of a bedtime routine in young children: sleep, development, and beyond. Sleep Med Rev 40:93–108. https://doi.org/10.1016/j.smrv.2017.10.007
doi: 10.1016/j.smrv.2017.10.007
pubmed: 29195725
Hale L, Berger LM, LeBourgeois MK, Brooks-Gunn J (2009) Social and demographic predictors of preschoolers’ bedtime routines. J Dev Behav Pediatr JDBP 30:394–402. https://doi.org/10.1097/DBP.0b013e3181ba0e64
doi: 10.1097/DBP.0b013e3181ba0e64
pubmed: 19745760
Kitsaras G, Goodwin M, Allan J, Kelly M, Pretty I (2021) Bedtime routine characteristics and activities in families with young children in the north of England. Int J Environ Res Pub Health 18. https://doi.org/10.3390/ijerph18178983
doi: 10.3390/ijerph18178983
Mindell JA, Leichman ES, Lee C, Williamson AA, Walters RM (2017) Implementation of a nightly bedtime routine: how quickly do things improve? Infant Behav Dev 49:220–227. https://doi.org/10.1016/j.infbeh.2017.09.013
doi: 10.1016/j.infbeh.2017.09.013
pubmed: 28985580
pmcid: 6587179
Mindell JA, Meltzer LJ, Carskadon MA, Chervin RD (2009) Developmental aspects of sleep hygiene: findings from the 2004 National Sleep Foundation Sleep in America Poll. Sleep Med 10:771–779. https://doi.org/10.1016/j.sleep.2008.07.016
doi: 10.1016/j.sleep.2008.07.016
pubmed: 19285450
Philbrook LE, Teti DM (2016) Bidirectional associations between bedtime parenting and infant sleep: parenting quality, parenting practices, and their interaction. J Fam Psychol JFP J Div Fam Psychol Am Psychol Assoc Div 43(30):431–441. https://doi.org/10.1037/fam0000198
doi: 10.1037/fam0000198
Sadeh A, Mindell J, Luedtke K, Wiegand B (2009) Sleep and sleep ecology in the first 3 years: a web-based study. J Sleep Res 18:60–73. https://doi.org/10.1111/j.1365-2869.2008.00699.x
doi: 10.1111/j.1365-2869.2008.00699.x
pubmed: 19021850
Bruni O, Angriman M (2015) Pediatric insomnia: new insights in clinical assessment and treatment options. Arch Ital Biol. 153:144–156. https://doi.org/10.12871/000398292015239
doi: 10.12871/000398292015239
pubmed: 26742668
Etherton H, Blunden S, Hauck Y (2016) Discussion of extinction-based behavioral sleep interventions for young children and reasons why parents may find them difficult. J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med 12:1535–1543. https://doi.org/10.5664/jcsm.6284
doi: 10.5664/jcsm.6284
Kahn M, Barnett N, Gradisar M (2023) Implementation of behavioral interventions for infant sleep problems in real-world settings. J Pediatr 255:137-146.e2. https://doi.org/10.1016/j.jpeds.2022.10.038
doi: 10.1016/j.jpeds.2022.10.038
pubmed: 36375604
Erland LAE, Saxena PK (2017) Melatonin natural health products and supplements: presence of serotonin and significant variability of melatonin content. J Clin Sleep Med JCSM Off Publ Am Acad Sleep Med 13:275–281. https://doi.org/10.5664/jcsm.6462
doi: 10.5664/jcsm.6462
Consumer Product Safety Commission (2001) Child-resistant packaging for certain over-the-counter drug products. Final rule Fed Regist 66:40111–40116
Malow BA, Findling RL, Schroder CM, Maras A, Breddy J, Nir T, Zisapel N, Gringras P (2021) Sleep, growth, and puberty after 2 years of prolonged-release melatonin in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 60:252-261.e3. https://doi.org/10.1016/j.jaac.2019.12.007
doi: 10.1016/j.jaac.2019.12.007
pubmed: 31982581
Salanitro M, Wrigley T, Ghabra H, de Haan E, Hill CM, Solmi M, Cortese S (2022) Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: a systematic review and meta-analysis. Neurosci Biobehav Rev 139:104723. https://doi.org/10.1016/j.neubiorev.2022.104723
doi: 10.1016/j.neubiorev.2022.104723
pubmed: 35691474
Wei S, Smits MG, Tang X, Kuang L, Meng H, Ni S, Xiao M, Zhou X (2020) Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials. Sleep Med 68:1–8. https://doi.org/10.1016/j.sleep.2019.02.017
doi: 10.1016/j.sleep.2019.02.017
pubmed: 31982807