Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.
cancer
genetic analysis
mutations
neuroendocrine
oncogene
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
23 Apr 2024
23 Apr 2024
Historique:
medline:
16
4
2024
pubmed:
16
4
2024
entrez:
16
4
2024
Statut:
ppublish
Résumé
High-grade neuroendocrine cervical cancers (NETc) are exceedingly rare, highly aggressive tumors. We analyzed 64 NETc tumor samples by whole-exome sequencing (WES). Human papillomavirus DNA was detected in 65.6% (42/64) of the tumors. Recurrent mutations were identified in
Identifiants
pubmed: 38625939
doi: 10.1073/pnas.2321898121
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2321898121Subventions
Organisme : HHS | NIH | NCI | Advancing Science and Practice in the Retail Environment (ASPiRE)
ID : U01 CA176067-01A1
Organisme : HHS | NIH | NCI | Advancing Science and Practice in the Retail Environment (ASPiRE)
ID : CA-16359
Organisme : National Research Foundation of Korea (NRF)
ID : NRF2022R1A4A2000827
Déclaration de conflit d'intérêts
Competing interests statement:A.D.S. is listed as author in a paper (i.e.,