Massive Transfusion in Pediatric Patients on Extracorporeal Membrane Oxygenation: A Secondary Analysis of the Massive Transfusion in Children (MATIC) Study.
Journal
ASAIO journal (American Society for Artificial Internal Organs : 1992)
ISSN: 1538-943X
Titre abrégé: ASAIO J
Pays: United States
ID NLM: 9204109
Informations de publication
Date de publication:
15 Apr 2024
15 Apr 2024
Historique:
medline:
17
4
2024
pubmed:
17
4
2024
entrez:
16
4
2024
Statut:
aheadofprint
Résumé
Few data describe pediatric patients who receive massive transfusion for life-threatening hemorrhage (LTH) while on extracorporeal membrane oxygenation (ECMO). We present a retrospective secondary analysis of a multicenter prospective observational study to describe resource utilization and mortality in pediatric patients with LTH while on ECMO. Children who were on ECMO during an LTH were compared to children with LTH who were not on ECMO. Primary outcomes were volumes of blood products administered and 28 day mortality. Comparisons were assessed by two-sided Fisher's exact test or Wilcoxon rank sum test. A total of 449 children, including 36 on ECMO, were included. Compared to those not on ECMO, children on ECMO received a higher volume of blood products (110 [50-223] vs. 59 [28-113]) ml/kg, p = 0.002) and were more likely to receive antifibrinolytic therapy (39% vs. 10%, p < 0.001). Blood product ratios were similar. Extracorporeal membrane oxygenation patients had higher 28 day mortality (64% vs. 35%, p = 0.001), although 24 hour mortality was similar (17% vs. 23%, p = 0.5). In conclusion, children on ECMO with LTH experience high resource utilization and 28 day mortality. Studies are needed to identify children at risk for LTH and to evaluate ECMO-specific treatment strategies.
Identifiants
pubmed: 38626783
doi: 10.1097/MAT.0000000000002212
pii: 00002480-990000000-00467
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Christine Allen
(C)
Fabrizio Chiusolo
(F)
Adrienne L Davis
(AL)
Robert A Finkelstein
(RA)
Julie C Fitzgerald
(JC)
Barbara A Gaines
(BA)
Susan M Goobie
(SM)
Sheila J Hanson
(SJ)
Hilary A Hewes
(HA)
Laurie H Johnson
(LH)
Mark O McCollum
(MO)
Alison B Nair
(AB)
Robert B Rosenberg
(RB)
Thomas M Rouse
(TM)
Athina Sikavitsas
(A)
Marcy N Singleton
(MN)
Jeffrey S Upperman
(JS)
Adam M Vogel
(AM)
Hale Wills
(H)
Margaret K Winkler
(MK)
Informations de copyright
Copyright © ASAIO 2024.
Déclaration de conflit d'intérêts
Disclosure: M.E.S. is a consultant for Medtronic education services; P.C.S. is a consultant for Cerus, Hemanext, CSL Behring, and Haima and is founder and chief medical officer for Kalocyte. The other authors have no conflicts of interest to report.
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