[Gastrointestinal disorders in hyperkinetic movement disorders and ataxia].
Gastrointestinale Störungen bei hyperkinetischen Bewegungsstörungen und Ataxien.
Essential tremor
Gastrointestinal disorders
Hereditary ataxia
Huntington’s disease
Restless legs syndrome
Journal
Der Nervenarzt
ISSN: 1433-0407
Titre abrégé: Nervenarzt
Pays: Germany
ID NLM: 0400773
Informations de publication
Date de publication:
17 Apr 2024
17 Apr 2024
Historique:
accepted:
14
03
2024
medline:
17
4
2024
pubmed:
17
4
2024
entrez:
17
4
2024
Statut:
aheadofprint
Résumé
Disorders of the gastrointestinal tract in patients suffering from hypokinetic movement disorders, and in particular Parkinson's disease, have increasingly been the subject of more intensive neuromedical research. So far, few data are available for patients with hyperkinetic movement disorders and ataxias. This review article summarizes the currently available and relevant publications on this topic. The particular focus is on essential tremor, restless legs syndrome, Huntington's disease and the group of hereditary ataxias. Further intensive research will be necessary in the future to collect detailed information also for these disease symptoms about specific disturbance patterns, in order to understand the underlying pathological pathways and to derive specific treatment approaches. Störungen des Gastrointestinaltraktes sind bei Patient*innen mit hypokinetischen Bewegungsstörungen und insbesondere der Parkinson-Krankheit Gegenstand einer zunehmend intensiveren neuromedizinischen Forschung. Bei Patient*innen mit hyperkinetischen Bewegungsstörungen und Ataxien gibt es bislang weniger verfügbare Daten. Der vorliegende Artikel fasst die vorhandenen und relevanten Publikationen zu diesem Thema übersichtsartig zusammen. Besonders im Fokus stehen dabei der essenzielle Tremor, das Restless-legs-Syndrom, der Morbus Huntington sowie die Gruppe der hereditären Ataxien. Zukünftige Forschung ist notwendig, um auch bei diesen Krankheitsbildern detaillierte Informationen zu möglichen spezifischen Störungsmustern, den zugrunde liegenden Pathomechanismen sowie den daraus abzuleitenden Therapieansätzen zu erlangen.
Autres résumés
Type: Publisher
(ger)
Störungen des Gastrointestinaltraktes sind bei Patient*innen mit hypokinetischen Bewegungsstörungen und insbesondere der Parkinson-Krankheit Gegenstand einer zunehmend intensiveren neuromedizinischen Forschung. Bei Patient*innen mit hyperkinetischen Bewegungsstörungen und Ataxien gibt es bislang weniger verfügbare Daten. Der vorliegende Artikel fasst die vorhandenen und relevanten Publikationen zu diesem Thema übersichtsartig zusammen. Besonders im Fokus stehen dabei der essenzielle Tremor, das Restless-legs-Syndrom, der Morbus Huntington sowie die Gruppe der hereditären Ataxien. Zukünftige Forschung ist notwendig, um auch bei diesen Krankheitsbildern detaillierte Informationen zu möglichen spezifischen Störungsmustern, den zugrunde liegenden Pathomechanismen sowie den daraus abzuleitenden Therapieansätzen zu erlangen.
Identifiants
pubmed: 38630301
doi: 10.1007/s00115-024-01655-z
pii: 10.1007/s00115-024-01655-z
doi:
Types de publication
English Abstract
Journal Article
Review
Langues
ger
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
Références
Acar BA, Acar MAG, Acar T et al (2018) Patients with primary restless legs syndrome have higher prevalence of autonomic dysfunction and irritable bowel syndrome. Singapore Med J 59(10):539–544 (59)
doi: 10.11622/smedj.2018010
pubmed: 29372261
pmcid: 6199186
Andrich J, Schmitz T, Saft C et al (2002) Autonomic nervous system function in Huntington’s disease. JNNP 72(6):726–731
Andrich J, Wobben M, Klotz P et al (2009) Upper gastrointestinal findings in Huntington’s disease: patients suffer but do not complain. J Neural Transm 116(12):1607–1611
doi: 10.1007/s00702-009-0310-1
pubmed: 19771391
Aziz NA, Anguelova GV, Marinus J et al (2010) Autonomic symptoms in patients an pre-manifest mutation carriers of Huntington’s disease. Eur J Neurol 17(8):1068–1074
doi: 10.1111/j.1468-1331.2010.02973.x
pubmed: 20192977
Aziz NA, van der Burg JM, Landwehrmeyer GB et al (2008) Weight loss in Huntington disease increases with higher CAG repeat number. Neurology 71(19):1506–1513
doi: 10.1212/01.wnl.0000334276.09729.0e
pubmed: 18981372
Carroll JB, Bates GP, Steffan J et al (2015) Treating the whole body in Huntington’s diseae. Lancet Neurol 14(11):1135–1142
doi: 10.1016/S1474-4422(15)00177-5
pubmed: 26466780
Claus I, Muhle P, Czechowski J et al (2021) Expiratory Muscle Strength Training for Therapy of Pharyngeal Dysphagia in Parkinson’s Disease. Mov Disord 36(8):1815–1824
doi: 10.1002/mds.28552
pubmed: 33650729
De Joanna G, De Rosa A, Salvatore E et al (2008) Autonomic nervous system in spinocerebellar ataxia type 2: a cardiovascular neurophysiologic study. J Neurol Sci 275(1–2):60–63
doi: 10.1016/j.jns.2008.07.015
pubmed: 18755482
Djousse L, Knowlton B, Cupples LA et al (2002) Weight loss in early stage of Huntington’s disease. Neurology 59(9):1325–1330
doi: 10.1212/01.WNL.0000031791.10922.CF
pubmed: 12427878
De Tommaso M, Nuzzi A, Dellomonaco AR et al (2015) Dysphagie in Huntington’s disease: correlation with clinical features. Eur Neurol 74(1–2):49–53
doi: 10.1159/000435833
pubmed: 26183666
Erdal Y, Akdogan O, Nalbantoglu M et al (2020) Autonomic dysfunction in Restless Legs Syndrome. Sleep Breath 24(3):995–999
doi: 10.1007/s11325-019-01939-8
pubmed: 31520300
Finger ME, Madden LL, Haq IU et al (2019) Analysis of the prevalence and onset of dysphonia and dyphagia symptomes in movement disorders at an academic medical center. J Clin Neurosci 64:111–115
doi: 10.1016/j.jocn.2019.03.043
pubmed: 30948311
pmcid: 6534463
Heemskerk AW, Roos RA (2011) Dysphagia in Huntington’s disease: a review. Dysphagia 26(1):62–66
doi: 10.1007/s00455-010-9302-4
pubmed: 20838817
Heemskerk AW, Verbist BM, Marinus J et al (2014) The Huntington’s Disease Dysphagia Scale. Mov Disord 29(10):1312–1316
doi: 10.1002/mds.25922
pubmed: 24862624
Isono C, Hirano M, Sakamoto H et al (2013) Differences in dysphagia between spinocerebellar ataxia type 3 and type 6. Dysphagia 28(3):413–418
doi: 10.1007/s00455-013-9450-4
pubmed: 23515636
Jardim LB, Pereira MI, Silveira I et al (2001) Neurologic findings in Machado-Joseph disease: relation with disease duration, subtypes, and (CAG)n. Arch Neurol 58(6):899–904
doi: 10.1001/archneur.58.6.899
pubmed: 11405804
Kagel MC, Leopold NA (1992) Dysphagia in Huntington’s disease: A 16-year retrospective. Dysphagia 7(2):106–114
doi: 10.1007/BF02493441
pubmed: 1533361
Lapa S, Claus I, Reitz SC et al (2020) Effect of thalamic deep brain stimulation on swallowing in patients with essential tremor. Ann Clin Transl Neurol 7:1174–1180
doi: 10.1002/acn3.51099
pubmed: 32548923
pmcid: 7359107
Louis ED, Michalec M (2015) Reduced body mass index in essential tremor: a study of 382 cases and 392 matched controls. Eur J Neurol 22(2):384–388
doi: 10.1111/ene.12589
pubmed: 25367457
Manor Y, Oestreicher-Kedem Y, Gad A et al (2019) Dysphagia characteristics in Huntington’s disease patients: insights from the fiberoptic endoscopic evaluation of swallowing and the swallowing disturbance questionnaire. CNS Spectr 24(4):413–418
doi: 10.1017/S1092852918001037
pubmed: 30198457
Moffitt H, McPhail GD, Woodmann B et al (2009) Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington’s disease. Plos One 4(11):e8025
doi: 10.1371/journal.pone.0008025
pubmed: 19956633
pmcid: 2778556
Mochizuki H, Kamakura K, Kumada M et al (1999) A patient with Huntington’s disease persenting with laryngeal chorea. Eur Neurol 41:199–120
doi: 10.1159/000008019
Mouro Pinto R, Arning L, Giordano JV et al (2020) Patterns of CAG repeat instability in the central nervous system and periphery in Huntington’s disease and in spinocerebellar ataxia type 1. Hum Mol Genet 29(15):2551–2567
doi: 10.1093/hmg/ddaa139
pubmed: 32761094
pmcid: 7471505
Opal P, Ashizawa T (1993) Spinozerebellar ataxia type 1. GeneReviews(®) Seattle, WA
Pradeep S, Mehanna R (2021) Gastrointestinal disorders in hyperkinetic movement disorders and ataxia. Parkinsonism Relat Disord 90:125–133
doi: 10.1016/j.parkreldis.2021.09.005
pubmed: 34544654
Reyes A, Cruickshank T, Nosaka K et al (2015) Respiratory muscle strength training on pulmonary and swallowing function in patients with Huntington’s disease: a pilot randomised controlled trial. Clin Rehabil 29(10):961–973
doi: 10.1177/0269215514564087
pubmed: 25552526
Saft C, Burgunder JM, Dose M et al (2023) Symptomatic treatment options for Huntington’s disease (guidelines of the German Neurological Society). Neurol Res Pract 5(1):61
doi: 10.1186/s42466-023-00285-1
pubmed: 37968732
pmcid: 10652593
Saft C, Andrich J, Fälker M et al (2011) No evidence of impaired gastric emptying in early Huntington’s disaese. PLoS Curr 25(3):RRN1284
Schindler A, Pizzorni N, Sassone J et al (2020) Fiberoptic endoscopic evaluation of swallowing in early-to-advanced stage Huntington’s diseaes. Sci Rep 10:15242
doi: 10.1038/s41598-020-72250-w
pubmed: 32943712
pmcid: 7499207
Shneyder CH, Adler JG, Hentz H et al (2013) Autonomic complaints in patients with restless legs syndrome. Sleep Med 14(12):1413–1416
doi: 10.1016/j.sleep.2013.08.781
pubmed: 24152795
pmcid: 4105217
Stevanin G, Broussolle E, Steichenberger N et al (2005) Spinocerebellar ataxia with sensory neuropathy (SCA 25). Cerebellum 4(1):58–61
doi: 10.1080/14734220510007932
pubmed: 15895562
Takahashi H, Ishikawa K, Tsutsumi T et al (2004) A clinical and genetic study in a large cohort of patients with spinocerebellar ataxia type 6. J Hum Genet 49(5):256–264
doi: 10.1007/s10038-004-0142-7
pubmed: 15362569
Trejo A, Boll MC, Alonso A et al (2005) Use of oral nutritional supplements in patients with Huntington’s diseae. Nutrition 21(9):889–894
doi: 10.1016/j.nut.2004.12.012
pubmed: 16087319
Van den Burg JM, Winqvist A, Aziz NA, Maat-Schiemann ML, Roos AG, Bates GP et al (2011) Gastrointestinal dysfunction contributes to weight loss in Huntington’s disease mice. Neurobiol Dis 44(1):1–8
doi: 10.1016/j.nbd.2011.05.006
pubmed: 21624468
Velasquez-Perez L, Rodriguez-Labrada R, Cruz-Rivas EM et al (2014) Comprehensive study of early features in spinocerebellar ataxia 2: delineating the prodromal stage of the disease. Cerebellum 13(5):568–579
doi: 10.1007/s12311-014-0574-3
Verlasquez-Perez L, Medrano-Montero J, Rodriguez-Labrada R et al (2020) Cuban Hereditary Ataxias, Hereditary ataxias in Cuba: a nationwide epidemiological and clinical study in 1001 patients. Cerebellum 19(2):252–264
doi: 10.1007/s12311-020-01107-9
Warnecke T, Schäfer KH, Claus I et al (2022) Gastrointestinal involvement in Parkinson’s disease: Pathophysiology, diagnosis, and management. NPJ Parkinsons Dis 8(1):31
doi: 10.1038/s41531-022-00295-x
pubmed: 35332158
pmcid: 8948218
Weinstock LB, Walters AS (2012) Restless legs syndrome in patients with irritable bowel syndrome and restless legs syndrome in the general population. J Sleep Res 21(5):569–576
doi: 10.1111/j.1365-2869.2012.01011.x