Illuminating the complete ß-cell mass of the human pancreas- signifying a new view on the islets of Langerhans.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
18 Apr 2024
18 Apr 2024
Historique:
received:
01
11
2023
accepted:
10
04
2024
medline:
19
4
2024
pubmed:
18
4
2024
entrez:
17
4
2024
Statut:
epublish
Résumé
Pancreatic islets of Langerhans play a pivotal role in regulating blood glucose homeostasis, but critical information regarding their mass, distribution and composition is lacking within a whole organ context. Here, we apply a 3D imaging pipeline to generate a complete account of the insulin-producing islets throughout the human pancreas at a microscopic resolution and within a maintained spatial 3D context. These data show that human islets are far more heterogenous than previously accounted for with regards to their size distribution and cellular make up. By deep tissue 3D imaging, this in-depth study demonstrates that 50% of the human insulin-expressing islets are virtually devoid of glucagon-producing α-cells, an observation with significant implications for both experimental and clinical research.
Identifiants
pubmed: 38632302
doi: 10.1038/s41467-024-47686-7
pii: 10.1038/s41467-024-47686-7
pmc: PMC11024155
doi:
Substances chimiques
Insulin
0
Blood Glucose
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3318Subventions
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : NNF21OC0069771
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : 0084520
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : NNF20OC0063600
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : DNR: 2017-01307
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2023-02221
Organisme : Kempestiftelserna (Kempe Foundations)
ID : SMK-1455
Organisme : Barndiabetesfonden
ID : 2022-12-06
Organisme : Diabetesfonden (Stiftelsen Svenska Diabetesförbundets Forskningsfond)
ID : DIA2021-59
Informations de copyright
© 2024. The Author(s).
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