Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps.

Humans Colonic Polyps / pathology Prevalence Risk Factors Colorectal Neoplasms / pathology Adenoma / pathology Biomarkers, Tumor
Colorectal carcinoma in situ Colorectal polyps Neoplastic polyps Prevalence Tumor markers

Journal

Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741

Informations de publication

Date de publication:
17 Apr 2024
Historique:
received: 01 09 2023
accepted: 20 03 2024
medline: 19 4 2024
pubmed: 18 4 2024
entrez: 17 4 2024
Statut: epublish

Résumé

Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps. Inpatients admitted from January 2018 to May 2023 were screened through the hospital information system. Polyps were classified according to pathological morphology. The prevalence of polyps was described by frequency and 95% confidence interval. Univariate and multivariate logistic regression analyses were used to explore the risk factors for CCS and neoplastic polyps. In total, 2329 individuals with 3550 polyps were recruited. Among all patients, 76.99% had neoplastic polyps and 44.31% had advanced adenomas. Tubular adenoma had the highest prevalence at 60.15%, and the prevalence of CCS was 3.86%. Patients with a colorectal polyp diameter ≥ 1.0 cm or number ≥ 3 were 8.07 times or 1.98 times more likely to develop CCS than were those with a diameter < 1.0 cm or number < 3, respectively (OR 8.07, 95%CI 4.48-14.55, p < 0.0001; and OR 1.98, 95%CI 1.27-3.09, p = 0.002). The risk of CCS with schistosome egg deposition was also significantly increased (OR 2.70, 95%CI 1.05-6.98). The higher the levels of carbohydrate antigen (CA) 724 (OR 1.01, 95%CI 1.00-1.02) and CA211 (OR 1.16, 95%CI 1.03-1.32) in patients with colorectal polyps were, the greater the risk of CCS. When colorectal neoplastic polyps were analyzed, we discovered that for each 1-year increase in age, the risk of neoplastic polyps increased by 3% (OR 1.03, 95%CI 1.02-1.04), p < 0.0001. Patients with a polyp diameter ≥ 1.0 cm had a 2.11-fold greater risk of neoplastic polyps compared to diameter < 1.0 cm patients (OR 3.11, 95%CI 2.48-3.92), p < 0.0001. In addition, multiple polyps and CA199 levels are risk factors for neoplastic polyps. More than 3/4 of colorectal polyp patients have neoplastic polyps. Patients are more inclined to develop CCS and neoplastic polyps if they have large polyps (> 1.0 cm) or multifocal polyps. The levels of the tumor markers CA724 and CA211 show some potential usefulness for predicting CCS and may be exploited for early identification of high-risk populations.

Sections du résumé

BACKGROUND BACKGROUND
Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps.
METHODS METHODS
Inpatients admitted from January 2018 to May 2023 were screened through the hospital information system. Polyps were classified according to pathological morphology. The prevalence of polyps was described by frequency and 95% confidence interval. Univariate and multivariate logistic regression analyses were used to explore the risk factors for CCS and neoplastic polyps.
RESULTS RESULTS
In total, 2329 individuals with 3550 polyps were recruited. Among all patients, 76.99% had neoplastic polyps and 44.31% had advanced adenomas. Tubular adenoma had the highest prevalence at 60.15%, and the prevalence of CCS was 3.86%. Patients with a colorectal polyp diameter ≥ 1.0 cm or number ≥ 3 were 8.07 times or 1.98 times more likely to develop CCS than were those with a diameter < 1.0 cm or number < 3, respectively (OR 8.07, 95%CI 4.48-14.55, p < 0.0001; and OR 1.98, 95%CI 1.27-3.09, p = 0.002). The risk of CCS with schistosome egg deposition was also significantly increased (OR 2.70, 95%CI 1.05-6.98). The higher the levels of carbohydrate antigen (CA) 724 (OR 1.01, 95%CI 1.00-1.02) and CA211 (OR 1.16, 95%CI 1.03-1.32) in patients with colorectal polyps were, the greater the risk of CCS. When colorectal neoplastic polyps were analyzed, we discovered that for each 1-year increase in age, the risk of neoplastic polyps increased by 3% (OR 1.03, 95%CI 1.02-1.04), p < 0.0001. Patients with a polyp diameter ≥ 1.0 cm had a 2.11-fold greater risk of neoplastic polyps compared to diameter < 1.0 cm patients (OR 3.11, 95%CI 2.48-3.92), p < 0.0001. In addition, multiple polyps and CA199 levels are risk factors for neoplastic polyps.
CONCLUSION CONCLUSIONS
More than 3/4 of colorectal polyp patients have neoplastic polyps. Patients are more inclined to develop CCS and neoplastic polyps if they have large polyps (> 1.0 cm) or multifocal polyps. The levels of the tumor markers CA724 and CA211 show some potential usefulness for predicting CCS and may be exploited for early identification of high-risk populations.

Identifiants

DOI: 10.1186/s12967-024-05111-z PMID: 38632639 PMC: PMC11022362
pubmed: 38632639
doi: 10.1186/s12967-024-05111-z
pii: 10.1186/s12967-024-05111-z
pmc: PMC11022362
doi:

Substances chimiques

Biomarkers, Tumor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

361

Subventions

Organisme : the Disciplinary Construction Project of Minhang Hospital, Shanghai
ID : YJXK-2021-08

Informations de copyright

© 2024. The Author(s).

Références

Cancer Res. 1996 Nov 15;56(22):5293-8
pubmed: 8912871
Endoscopy. 2002 Mar;34(3):226-36
pubmed: 11870575
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Gut Liver. 2020 Jul 15;14(4):399-411
pubmed: 31547641
CA Cancer J Clin. 1997 Mar-Apr;47(2):93-112
pubmed: 9074488
Clin Chem. 2001 Apr;47(4):624-30
pubmed: 11274010
Clin Gastroenterol Hepatol. 2023 Jul;21(7):1924-1936.e9
pubmed: 36270618
Gastroenterology. 2020 Nov;159(5):1916-1934.e2
pubmed: 33159840
Gastroenterol Clin North Am. 1997 Mar;26(1):1-17
pubmed: 9119435
Eur J Cancer. 2003 Apr;39(6):718-27
pubmed: 12651195
CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32
pubmed: 26808342
Lancet Gastroenterol Hepatol. 2020 Jun;5(6):537-547
pubmed: 32192628
Nat Rev Dis Primers. 2018 Aug 9;4(1):13
pubmed: 30093684
Clin Gastroenterol Hepatol. 2009 Feb;7(2):192-7
pubmed: 18849014
J Exp Med. 1965 Sep 1;122(3):467-81
pubmed: 4953873

Auteurs

Xiaojuan Li (X)

Department of Gastroenterology, Minhang Hospital, Fudan University, Shanghai, 201199, China.
ORCID: 0000-0002-6975-3268

Mengting Hu (M)

Department of General Medicine, Minhang Hospital, Fudan University, Shanghai, 201199, China.

Zhangjun Wang (Z)

Proprietary Trading Department, Huaan Securities Co., Ltd, Shanghai, 200120, China.

Mei Liu (M)

Department of General Medicine, Minhang Hospital, Fudan University, Shanghai, 201199, China. liu_mei@fudan.edu.cn.

Ying Chen (Y)

Department of Gastroenterology, Minhang Hospital, Fudan University, Shanghai, 201199, China. chenying_1120@fudan.edu.cn.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prevalence of diverse colorectal polyps and...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Polypes › Polypes intestinaux › Polypes coliques › Prevalence of diverse colorectal polyps and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Prevalence of diverse colorectal polyps and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Prevalence of diverse colorectal polyps and...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Prevalence of diverse colorectal polyps and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Adénomes › Prevalence of diverse colorectal polyps and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Prevalence of diverse colorectal polyps and...