Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells.
PANoptosis
Pyroptosis
ferroptosis
intervertebral disc degeneration
mode of cell death
senescence
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
17 Apr 2024
17 Apr 2024
Historique:
revised:
16
03
2024
received:
04
12
2023
accepted:
06
04
2024
medline:
18
4
2024
pubmed:
18
4
2024
entrez:
18
4
2024
Statut:
aheadofprint
Résumé
Intervertebral disc degeneration (IVDD) is a common chronic orthopaedic disease in orthopaedics that imposes a heavy economic burden on people and society. Although it is well established that IVDD is associated with genetic susceptibility, ageing and obesity, its pathogenesis remains incompletely understood. Previously, IVDD was thought to occur because of excessive mechanical loading leading to destruction of nucleus pulposus cells (NPCs), but studies have shown that IVDD is a much more complex process associated with inflammation, metabolic factors and NPCs death and can involve all parts of the disc, characterized by causing NPCs death and extracellular matrix (ECM) degradation. The damage pattern of NPCs in IVDD is like that of some programmed cell death, suggesting that IVDD is associated with programmed cell death. Although apoptosis and pyroptosis of NPCs have been studied in IVDD, the pathogenesis of intervertebral disc degeneration can still not be fully elucidated by using only traditional cell death modalities. With increasing research, some new modes of cell death, PANoptosis, ferroptosis and senescence have been found to be closely related to intervertebral disc degeneration. Among these, PANoptosis combines essential elements of pyroptosis, apoptosis and necroptosis to form a highly coordinated and dynamically balanced programmed inflammatory cell death process. Furthermore, we believe that PANoptosis may also crosstalk with pyroptosis and senescence. Therefore, we review the progress of research on multiple deaths of NPCs in IVDD to provide guidance for clinical treatment.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14226Subventions
Organisme : the Project Supported by the Sichuan Science and Technology Department Project Development Project
ID : 22ZDYF512
Organisme : the Program for Luzhou Municipal People's Government-Southwest Medical University science and technology strategic cooperation climbing project
ID : 2021LZXNYD-D02
Organisme : Luzhou city science and technology innovation seedling cultivation plan
ID : 2022-RCM-178
Organisme : Luzhou city science and technology research and development projects
ID : 2022-SYF-42
Organisme : Sichuan Provincial Science and Technology Plan Joint Innovation Special Project
ID : 2022YFS0609-B3
Informations de copyright
© 2024 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.
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