N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system.
Benzamide
Depression
Mice
Noradrenergic system
Selenium
Serotonergic system
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
18 Apr 2024
18 Apr 2024
Historique:
received:
18
10
2023
accepted:
08
04
2024
medline:
18
4
2024
pubmed:
18
4
2024
entrez:
18
4
2024
Statut:
aheadofprint
Résumé
Major Depressive Disorder (MDD) significantly impairs the quality of life for those affected. While the exact causes of MDD are not fully understood, the deficit of monoamines, especially serotonin and noradrenaline, is widely accepted. Resistance to long-term treatments and adverse effects are often observed, highlighting the need for new pharmacological therapies. Synthetic organic compounds containing selenium have exhibited pharmacological properties, including potential antidepressant effects. To evaluate the antidepressant-like effect of N-(3-((3-(trifluoromethyl)phenyl)selenyl)prop-2-yn-1-yl) benzamide (CF Male Swiss mice were treated with CF CF This study pointed a new compound with antidepressant-like effect, and it could be considered for the development of new antidepressants.
Identifiants
pubmed: 38635075
doi: 10.1007/s00213-024-06588-8
pii: 10.1007/s00213-024-06588-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Universidade Federal da Fronteira Sul
ID : 121/GR/UFFS/2021
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 001
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 21/2551-0000728-1
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 21/2551-0000614-5
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 305626/2022-1
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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