Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.


Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
18 Apr 2024
Historique:
received: 24 05 2023
accepted: 05 03 2024
medline: 19 4 2024
pubmed: 19 4 2024
entrez: 18 4 2024
Statut: aheadofprint

Résumé

Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental, axon guidance and transcription factors (for example, FOXP2, EFNA5 and DCC), synaptic structure and function genes (for example, PCLO, NCAM1 and PDE4B) and endocrine or immune regulators (for example, ESR1, TRAF3 and TANK). Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.

Identifiants

pubmed: 38637617
doi: 10.1038/s41588-024-01707-9
pii: 10.1038/s41588-024-01707-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH106595
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH106595
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH106595

Informations de copyright

© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.

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Auteurs

Caroline M Nievergelt (CM)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. cnievergelt@ucsd.edu.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA. cnievergelt@ucsd.edu.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA. cnievergelt@ucsd.edu.

Adam X Maihofer (AX)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.

Elizabeth G Atkinson (EG)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Chia-Yen Chen (CY)

Biogen Inc.,Translational Sciences, Cambridge, MA, USA.

Karmel W Choi (KW)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

Jonathan R I Coleman (JRI)

King's College London, National Institute for Health and Care Research Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.

Nikolaos P Daskalakis (NP)

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Center of Excellence in Depression and Anxiety Disorders, Belmont, MA, USA.

Laramie E Duncan (LE)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

Renato Polimanti (R)

VA Connecticut Healthcare Center, West Haven, CT, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Cindy Aaronson (C)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Ananda B Amstadter (AB)

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA.

Soren B Andersen (SB)

The Danish Veteran Centre, Research and Knowledge Centre, Ringsted, Denmark.

Ole A Andreassen (OA)

Oslo University Hospital, Division of Mental Health and Addiction, Oslo, Norway.
University of Oslo, Institute of Clinical Medicine, Oslo, Norway.

Paul A Arbisi (PA)

Minneapolis VA Health Care System, Mental Health Service Line, Minneapolis, MN, USA.
Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.

Allison E Ashley-Koch (AE)

Duke University, Duke Molecular Physiology Institute, Durham, NC, USA.

S Bryn Austin (SB)

Boston Children's Hospital, Division of Adolescent and Young Adult Medicine, Boston, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Esmina Avdibegoviç (E)

Department of Psychiatry, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina.

Dragan Babić (D)

Department of Psychiatry, University Clinical Center of Mostar, Mostar, Bosnia and Herzegovina.

Silviu-Alin Bacanu (SA)

Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.

Dewleen G Baker (DG)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.

Anthony Batzler (A)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Jean C Beckham (JC)

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Research, Durham VA Health Care System, Durham, NC, USA.
VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA.

Sintia Belangero (S)

Department of Morphology and Genetics, Universidade Federal de São Paulo, São Paulo, Brazil.
Department of Psychiatry, Universidade Federal de São Paulo, Laboratory of Integrative Neuroscience, São Paulo, Brazil.

Corina Benjet (C)

Instituto Nacional de Psiquiatraía Ramón de la Fuente Muñiz, Center for Global Mental Health, Mexico City, Mexico.

Carisa Bergner (C)

Medical College of Wisconsin, Comprehensive Injury Center, Milwaukee, WI, USA.

Linda M Bierer (LM)

Department of Psychiatry, James J. Peters VA Medical Center, Bronx, NY, USA.

Joanna M Biernacka (JM)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Laura J Bierut (LJ)

Department of Psychiatry, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.

Jonathan I Bisson (JI)

Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, UK.

Marco P Boks (MP)

Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht, The Netherlands.

Elizabeth A Bolger (EA)

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Amber Brandolino (A)

Department of Surgery, Division of Trauma & Acute Care Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Gerome Breen (G)

King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
King's College London, NIHR Maudsley BRC, London, UK.

Rodrigo Affonseca Bressan (RA)

Department of Psychiatry, Universidade Federal de São Paulo, Laboratory of Integrative Neuroscience, São Paulo, Brazil.
Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.

Richard A Bryant (RA)

University of New South Wales, School of Psychology, Sydney, New South Wales, Australia.

Angela C Bustamante (AC)

Department of Internal Medicine, University of Michigan Medical School, Division of Pulmonary and Critical Care Medicine, Ann Arbor, MI, USA.

Jonas Bybjerg-Grauholm (J)

Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.

Marie Bækvad-Hansen (M)

Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.

Anders D Børglum (AD)

The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Aarhus University, Centre for Integrative Sequencing, iSEQ, Aarhus, Denmark.
Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.

Sigrid Børte (S)

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, K. G. Jebsen Center for Genetic Epidemiology, Trondheim, Norway.
Oslo University Hospital, Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo, Norway.

Leah Cahn (L)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Joseph R Calabrese (JR)

Case Western Reserve University, School of Medicine, Cleveland, OH, USA.
Department of Psychiatry, University Hospitals, Cleveland, OH, USA.

Jose Miguel Caldas-de-Almeida (JM)

Chronic Diseases Research Centre (CEDOC), Lisbon Institute of Global Mental Health, Lisbon, Portugal.

Chris Chatzinakos (C)

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Division of Depression and Anxiety Disorders, Belmont, MA, USA.

Sheraz Cheema (S)

University of Toronto, CanPath National Coordinating Center, Toronto, Ontario, Canada.

Sean A P Clouston (SAP)

Stony Brook University, Family, Population, and Preventive Medicine, Stony Brook, NY, USA.
Stony Brook University, Public Health, Stony Brook, NY, USA.

Lucía Colodro-Conde (L)

QIMR Berghofer Medical Research Institute, Mental Health & Neuroscience Program, Brisbane, Queensland, Australia.

Brandon J Coombes (BJ)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Carlos S Cruz-Fuentes (CS)

Department of Genetics, Instituto Nacional de Psiquiatraía Ramón de la Fuente Muñiz, Mexico City, Mexico.

Anders M Dale (AM)

Department of Radiology, Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.

Shareefa Dalvie (S)

Department of Pathology, University of Cape Town, Division of Human Genetics, Cape Town, South Africa.

Lea K Davis (LK)

Vanderbilt University Medical Center, Vanderbilt Genetics Institute, Nashville, TN, USA.

Jürgen Deckert (J)

University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, Denmark.

Douglas L Delahanty (DL)

Department of Psychological Sciences, Kent State University, Kent, OH, USA.

Michelle F Dennis (MF)

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Research, Durham VA Health Care System, Durham, NC, USA.
VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA.

Frank Desarnaud (F)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Christopher P DiPietro (CP)

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
McLean Hospital, Division of Depression and Anxiety Disorders, Belmont, MA, USA.

Seth G Disner (SG)

Minneapolis VA Health Care System, Research Service Line, Minneapolis, MN, USA.
Department of Psychiatry & Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.

Anna R Docherty (AR)

Huntsman Mental Health Institute, Salt Lake City, UT, USA.
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.

Katharina Domschke (K)

University of Freiburg, Faculty of Medicine, Centre for Basics in Neuromodulation, Freiburg, Denmark.
Department of Psychiatry and Psychotherapy, University of Freiburg, Faculty of Medicine, Freiburg, Denmark.

Grete Dyb (G)

University of Oslo, Institute of Clinical Medicine, Oslo, Norway.
Norwegian Centre for Violence and Traumatic Stress Studies, Oslo, Norway.

Alma Džubur Kulenović (AD)

Department of Psychiatry, University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Howard J Edenberg (HJ)

Indiana University School of Medicine, Biochemistry and Molecular Biology, Indianapolis, IN, USA.
Indiana University School of Medicine, Medical and Molecular Genetics, Indianapolis, IN, USA.

Alexandra Evans (A)

Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, UK.

Chiara Fabbri (C)

King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Negar Fani (N)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Lindsay A Farrer (LA)

Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Adriana Feder (A)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Norah C Feeny (NC)

Department of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.

Janine D Flory (JD)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

David Forbes (D)

Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.

Carol E Franz (CE)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

Sandro Galea (S)

Boston University School of Public Health, Boston, MA, USA.

Melanie E Garrett (ME)

Duke University, Duke Molecular Physiology Institute, Durham, NC, USA.

Bizu Gelaye (B)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Joel Gelernter (J)

VA Connecticut Healthcare Center, Psychiatry Service, West Haven, CT, USA.
Department of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.

Elbert Geuze (E)

Netherlands Ministry of Defence, Brain Research and Innovation Centre, Utrecht, The Netherlands.
Department of Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.

Charles F Gillespie (CF)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Slavina B Goleva (SB)

Vanderbilt University Medical Center, Vanderbilt Genetics Institute, Nashville, TN, USA.
National Institutes of Health, National Human Genome Research Institute, Bethesda, MD, USA.

Scott D Gordon (SD)

QIMR Berghofer Medical Research Institute, Mental Health & Neuroscience Program, Brisbane, Queensland, Australia.

Aferdita Goçi (A)

Department of Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo.

Lana Ruvolo Grasser (LR)

Wayne State University School of Medicine, Psychiatry and Behavioral Neurosciencess, Detroit, MI, USA.

Camila Guindalini (C)

Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Greenslopes, Queensland, Australia.

Magali Haas (M)

Cohen Veterans Bioscience, New York City, NY, USA.

Saskia Hagenaars (S)

King's College London, National Institute for Health and Care Research Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK.
King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.

Michael A Hauser (MA)

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.

Andrew C Heath (AC)

Department of Genetics, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.

Sian M J Hemmings (SMJ)

Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
SAMRC Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa.

Victor Hesselbrock (V)

University of Connecticut School of Medicine, Psychiatry, Farmington, CT, USA.

Ian B Hickie (IB)

University of Sydney, Brain and Mind Centre, Sydney, New South Wales, Australia.

Kelleigh Hogan (K)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.

David Michael Hougaard (DM)

Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.

Hailiang Huang (H)

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Department of Medicine, Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.

Laura M Huckins (LM)

Department of Psychiatry, Yale University, New Haven, CT, USA.

Kristian Hveem (K)

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, K. G. Jebsen Center for Genetic Epidemiology, Trondheim, Norway.

Miro Jakovljević (M)

Department of Psychiatry, University Hospital Center of Zagreb, Zagreb, Croatia.

Arash Javanbakht (A)

Wayne State University School of Medicine, Psychiatry and Behavioral Neurosciencess, Detroit, MI, USA.

Gregory D Jenkins (GD)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Jessica Johnson (J)

Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Ian Jones (I)

Cardiff University, National Centre for Mental Health, Cardiff University Centre for Psychiatric Genetics and Genomics, Cardiff, UK.

Tanja Jovanovic (T)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Karen-Inge Karstoft (KI)

The Danish Veteran Centre, Research and Knowledge Centre, Ringsted, Denmark.
Department of Psychology, University of Copenhagen, Copenhagen, Denmark.

Milissa L Kaufman (ML)

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

James L Kennedy (JL)

Centre for Addiction and Mental Health, Neurogenetics Section, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada.
Centre for Addiction and Mental Health, Tanenbaum Centre for Pharmacogenetics, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.

Ronald C Kessler (RC)

Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.

Alaptagin Khan (A)

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Nathan A Kimbrel (NA)

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC), Genetics Research Laboratory, Durham, NC, USA.
Durham VA Health Care System, Mental Health Service Line, Durham, NC, USA.

Anthony P King (AP)

The Ohio State University, College of Medicine, Institute for Behavioral Medicine Research, Columbus, OH, USA.

Nastassja Koen (N)

University of Cape Town, Department of Psychiatry & Neuroscience Institute, SA MRC Unit on Risk & Resilience in Mental Disorders, Cape Town, South Africa.

Roman Kotov (R)

Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA.

Henry R Kranzler (HR)

Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Kristi Krebs (K)

University of Tartu, Institute of Genomics, Estonian Genome Center, Tartu, Estonia.

William S Kremen (WS)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

Pei-Fen Kuan (PF)

Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA.

Bruce R Lawford (BR)

Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, Queensland, Australia.

Lauren A M Lebois (LAM)

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Center of Excellence in Depression and Anxiety Disorders, Belmont, MA, USA.

Kelli Lehto (K)

University of Tartu, Institute of Genomics, Estonian Genome Center, Tartu, Estonia.

Daniel F Levey (DF)

VA Connecticut Healthcare Center, West Haven, CT, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Catrin Lewis (C)

Cardiff University, National Centre for Mental Health, MRC Centre for Psychiatric Genetics and Genomics, Cardiff, UK.

Israel Liberzon (I)

Department of Psychiatry and Behavioral Sciences, Texas A&M University College of Medicine, Bryan, TX, USA.

Sarah D Linnstaedt (SD)

Department of Anesthesiology, UNC Institute for Trauma Recovery, Chapel Hill, NC, USA.

Mark W Logue (MW)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Boston University School of Medicine, Psychiatry, Biomedical Genetics, Boston, MA, USA.
VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.

Adriana Lori (A)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Yi Lu (Y)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Benjamin J Luft (BJ)

Department of Medicine, Stony Brook University, Stony Brook, NY, USA.

Michelle K Lupton (MK)

QIMR Berghofer Medical Research Institute, Mental Health & Neuroscience Program, Brisbane, Queensland, Australia.

Jurjen J Luykx (JJ)

Department of Psychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.
Department of Translational Neuroscience, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, The Netherlands.

Iouri Makotkine (I)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Jessica L Maples-Keller (JL)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Shelby Marchese (S)

Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Charles Marmar (C)

New York University, Grossman School of Medicine, New York City, NY, USA.

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Genetics, Brisbane, Queensland, Australia.

Gabriela A Martínez-Levy (GA)

Department of Genetics, Instituto Nacional de Psiquiatraía Ramón de la Fuente Muñiz, Mexico City, Mexico.

Kerrie McAloney (K)

QIMR Berghofer Medical Research Institute, Mental Health & Neuroscience Program, Brisbane, Queensland, Australia.

Alexander McFarlane (A)

University of Adelaide, Discipline of Psychiatry, Adelaide, South Australia, Australia.

Katie A McLaughlin (KA)

Department of Psychology, Harvard University, Boston, MA, USA.

Samuel A McLean (SA)

Department of Anesthesiology, UNC Institute for Trauma Recovery, Chapel Hill, NC, USA.
Department of Emergency Medicine, UNC Institute for Trauma Recovery, Chapel Hill, NC, USA.

Sarah E Medland (SE)

QIMR Berghofer Medical Research Institute, Mental Health & Neuroscience Program, Brisbane, Queensland, Australia.

Divya Mehta (D)

Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, Queensland, Australia.
Queensland University of Technology, Centre for Genomics and Personalised Health, Kelvin Grove, Queensland, Australia.

Jacquelyn Meyers (J)

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.

Vasiliki Michopoulos (V)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Elizabeth A Mikita (EA)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.

Lili Milani (L)

University of Tartu, Institute of Genomics, Estonian Genome Center, Tartu, Estonia.

William Milberg (W)

VA Boston Healthcare System, GRECC/TRACTS, Boston, MA, USA.

Mark W Miller (MW)

Boston University School of Medicine, Psychiatry, Biomedical Genetics, Boston, MA, USA.
VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.

Rajendra A Morey (RA)

Duke University School of Medicine, Duke Brain Imaging and Analysis Center, Durham, NC, USA.

Charles Phillip Morris (CP)

Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, Queensland, Australia.

Ole Mors (O)

The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Aarhus University Hospital-Psychiatry, Psychosis Research Unit, Aarhus, Denmark.

Preben Bo Mortensen (PB)

The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Aarhus University, Centre for Integrative Sequencing, iSEQ, Aarhus, Denmark.
Aarhus University, Centre for Integrated Register-Based Research, Aarhus, Denmark.
Aarhus University, National Centre for Register-Based Research, Aarhus, Denmark.

Mary S Mufford (MS)

Department of Pathology, University of Cape Town, Division of Human Genetics, Cape Town, South Africa.

Elliot C Nelson (EC)

Department of Psychiatry, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA.

Merete Nordentoft (M)

The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
University of Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.

Sonya B Norman (SB)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
National Center for Post Traumatic Stress Disorder, Executive Division, White River Junction, VT, USA.

Nicole R Nugent (NR)

Department of Emergency Medicine, Alpert Brown Medical School, Providence, RI, USA.
Department of Pediatrics, Alpert Brown Medical School, Providence, RI, USA.
Department of Psychiatry and Human Behavior, Alpert Brown Medical School, Providence, RI, USA.

Meaghan O'Donnell (M)

Department of Psychiatry, University of Melbourne, Phoenix Australia, Melbourne, Victoria, Australia.

Holly K Orcutt (HK)

Department of Psychology, Northern Illinois University, DeKalb, IL, USA.

Pedro M Pan (PM)

Universidade Federal de São Paulo, Psychiatry, São Paulo, Brazil.

Matthew S Panizzon (MS)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

Gita A Pathak (GA)

VA Connecticut Healthcare Center, West Haven, CT, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Edward S Peters (ES)

University of Nebraska Medical Center, College of Public Health, Omaha, NE, USA.

Alan L Peterson (AL)

South Texas Veterans Health Care System, Research and Development Service, San Antonio, TX, USA.
Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Matthew Peverill (M)

Department of Psychology, University of Washington, Seattle, WA, USA.

Robert H Pietrzak (RH)

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA.

Melissa A Polusny (MA)

Minneapolis VA Health Care System, Mental Health Service Line, Minneapolis, MN, USA.
Department of Psychiatry & Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Center for Care Delivery and Outcomes Research (CCDOR), Minneapolis, MN, USA.

Bernice Porjesz (B)

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.

Abigail Powers (A)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Xue-Jun Qin (XJ)

Duke University, Duke Molecular Physiology Institute, Durham, NC, USA.

Andrew Ratanatharathorn (A)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology, Columbia University Mailmain School of Public Health, New York City, NY, USA.

Victoria B Risbrough (VB)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.

Andrea L Roberts (AL)

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Alex O Rothbaum (AO)

Department of Psychological Sciences, Emory University, Atlanta, GA, USA.
Department of Research and Outcomes, Skyland Trail, Atlanta, GA, USA.

Barbara O Rothbaum (BO)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Peter Roy-Byrne (P)

Department of Psychiatry, University of Washington, Seattle, WA, USA.

Kenneth J Ruggiero (KJ)

Department of Nursing, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.

Ariane Rung (A)

Department of Epidemiology, Louisiana State University Health Sciences Center, School of Public Health, New Orleans, LA, USA.

Heiko Runz (H)

Biogen Inc., Research & Development, Cambridge, MA, USA.

Bart P F Rutten (BPF)

Department of Psychiatry and Neuropsychology, Maastricht Universitair Medisch Centrum, School for Mental Health and Neuroscience, Maastricht, The Netherlands.

Stacey Saenz de Viteri (SS)

SUNY Downstate Health Sciences University, School of Public Health, Brooklyn, NY, USA.

Giovanni Abrahão Salum (GA)

Child Mind Institute, New York City, NY, USA.
Instituto Nacional de Psiquiatria de Desenvolvimento, São Paulo, Brazil.

Laura Sampson (L)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Sixto E Sanchez (SE)

Department of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.

Marcos Santoro (M)

Universidade Federal de São Paulo, Departamento de Bioquímica-Disciplina de Biologia Molecular, São Paulo, Brazil.

Carina Seah (C)

Department of Genetic and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Soraya Seedat (S)

Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stellenbosch University, SAMRC Extramural Genomics of Brain Disorders Research Unit, Cape Town, South Africa.

Julia S Seng (JS)

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Department of Women's and Gender Studies, University of Michigan, Ann Arbor, MI, USA.
University of Michigan, Institute for Research on Women and Gender, Ann Arbor, MI, USA.
University of Michigan, School of Nursing, Ann Arbor, MI, USA.

Andrey Shabalin (A)

Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.

Christina M Sheerin (CM)

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA.

Derrick Silove (D)

Department of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.

Alicia K Smith (AK)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Department of Gynecology and Obstetrics, Department of Psychiatry and Behavioral Sciences, Department of Human Genetics, Emory University, Atlanta, GA, USA.

Jordan W Smoller (JW)

Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA.

Scott R Sponheim (SR)

Minneapolis VA Health Care System, Mental Health Service Line, Minneapolis, MN, USA.
Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.

Dan J Stein (DJ)

University of Cape Town, Department of Psychiatry & Neuroscience Institute, SA MRC Unit on Risk & Resilience in Mental Disorders, Cape Town, South Africa.

Synne Stensland (S)

Oslo University Hospital, Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo, Norway.
Norwegian Centre for Violence and Traumatic Stress Studies, Oslo, Norway.

Jennifer S Stevens (JS)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Jennifer A Sumner (JA)

Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.

Martin H Teicher (MH)

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Developmental Biopsychiatry Research Program, Belmont, MA, USA.

Wesley K Thompson (WK)

Mental Health Centre Sct. Hans, Institute of Biological Psychiatry, Roskilde, Denmark.
University of California San Diego, Herbert Wertheim School of Public Health and Human Longevity Science, La Jolla, CA, USA.

Arun K Tiwari (AK)

Centre for Addiction and Mental Health, Neurogenetics Section, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada.
Centre for Addiction and Mental Health, Tanenbaum Centre for Pharmacogenetics, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Edward Trapido (E)

Department of Epidemiology, Louisiana State University Health Sciences Center, School of Public Health, New Orleans, LA, USA.

Monica Uddin (M)

University of South Florida College of Public Health, Genomics Program, Tampa, FL, USA.

Robert J Ursano (RJ)

Department of Psychiatry, Uniformed Services University, Bethesda, MD, USA.

Unnur Valdimarsdóttir (U)

Karolinska Institutet, Unit of Integrative Epidemiology, Institute of Environmental Medicine, Stockholm, Sweden.
University of Iceland, Faculty of Medicine, Center of Public Health Sciences, School of Health Sciences, Reykjavik, Iceland.

Miranda Van Hooff (M)

University of Adelaide, Adelaide Medical School, Adelaide, South Australia, Australia.

Eric Vermetten (E)

ARQ Nationaal Psychotrauma Centrum, Psychotrauma Research Expert Group, Diemen, The Netherlands.
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Department of Psychiatry, New York University School of Medicine, New York City, NY, USA.

Christiaan H Vinkers (CH)

Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, The Netherlands.
Department of Anatomy and Neurosciences, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Joanne Voisey (J)

Queensland University of Technology, School of Biomedical Sciences, Kelvin Grove, Queensland, Australia.
Queensland University of Technology, Centre for Genomics and Personalised Health, Kelvin Grove, Queensland, Australia.

Yunpeng Wang (Y)

Department of Psychology, University of Oslo, Lifespan Changes in Brain and Cognition (LCBC), Oslo, Norway.

Zhewu Wang (Z)

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Department of Mental Health, Ralph H Johnson VA Medical Center, Charleston, SC, USA.

Monika Waszczuk (M)

Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.

Heike Weber (H)

University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, Denmark.

Frank R Wendt (FR)

Department of Anthropology, University of Toronto, Dalla Lana School of Public Health, Toronto, Ontario, Canada.

Thomas Werge (T)

The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Copenhagen University Hospital, Institute of Biological Psychiatry, Mental Health Services, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen, The Globe Institute, Lundbeck Foundation Center for Geogenetics, Copenhagen, Denmark.

Michelle A Williams (MA)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Douglas E Williamson (DE)

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Research, Durham VA Health Care System, Durham, NC, USA.

Bendik S Winsvold (BS)

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, K. G. Jebsen Center for Genetic Epidemiology, Trondheim, Norway.
Oslo University Hospital, Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo, Norway.
Department of Neurology, Oslo University Hospital, Oslo, Norway.

Sherry Winternitz (S)

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Christiane Wolf (C)

University Hospital of Würzburg, Center of Mental Health, Psychiatry, Psychosomatics and Psychotherapy, Würzburg, Denmark.

Erika J Wolf (EJ)

VA Boston Healthcare System, National Center for PTSD, Boston, MA, USA.
Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.

Yan Xia (Y)

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Department of Medicine, Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.

Ying Xiong (Y)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Rachel Yehuda (R)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Department of Mental Health, James J. Peters VA Medical Center, Bronx, NY, USA.

Keith A Young (KA)

Central Texas Veterans Health Care System, Research Service, Temple, TX, USA.
Department of Psychiatry and Behavioral Sciences, Texas A&M University School of Medicine, Bryan, TX, USA.

Ross McD Young (RM)

Queensland University of Technology, School of Clinical Sciences, Kelvin Grove, Queensland, Australia.
University of the Sunshine Coast, The Chancellory, Sippy Downs, Queensland, Australia.

Clement C Zai (CC)

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Centre for Addiction and Mental Health, Neurogenetics Section, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada.
Centre for Addiction and Mental Health, Tanenbaum Centre for Pharmacogenetics, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada.

Gwyneth C Zai (GC)

Centre for Addiction and Mental Health, Neurogenetics Section, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada.
Centre for Addiction and Mental Health, Tanenbaum Centre for Pharmacogenetics, Toronto, Ontario, Canada.
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
Centre for Addiction and Mental Health, General Adult Psychiatry and Health Systems Division, Toronto, Ontario, Canada.

Mark Zervas (M)

Cohen Veterans Bioscience, New York City, NY, USA.

Hongyu Zhao (H)

Department of Biostatistics, Yale University, New Haven, CT, USA.

Lori A Zoellner (LA)

Department of Psychology, University of Washington, Seattle, WA, USA.

John-Anker Zwart (JA)

University of Oslo, Institute of Clinical Medicine, Oslo, Norway.
Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, K. G. Jebsen Center for Genetic Epidemiology, Trondheim, Norway.
Oslo University Hospital, Department of Research, Innovation and Education, Division of Clinical Neuroscience, Oslo, Norway.

Terri deRoon-Cassini (T)

Department of Surgery, Division of Trauma & Acute Care Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Sanne J H van Rooij (SJH)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Leigh L van den Heuvel (LL)

Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
SAMRC Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa.

Murray B Stein (MB)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.
University of California San Diego, School of Public Health, La Jolla, CA, USA.

Kerry J Ressler (KJ)

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Karestan C Koenen (KC)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA.

Classifications MeSH