Highly pathogenic avian influenza A(H5N1) virus in a common bottlenose dolphin (Tursiops truncatus) in Florida.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
18 Apr 2024
18 Apr 2024
Historique:
received:
25
06
2023
accepted:
10
04
2024
medline:
19
4
2024
pubmed:
19
4
2024
entrez:
18
4
2024
Statut:
epublish
Résumé
Since late 2021, highly pathogenic avian influenza (HPAI) viruses of A/goose/Guangdong/1/1996 (H5N1) lineage have caused widespread mortality in wild birds and poultry in the United States. Concomitant with the spread of HPAI viruses in birds are increasing numbers of mammalian infections, including wild and captive mesocarnivores and carnivores with central nervous system involvement. Here we report HPAI, A(H5N1) of clade 2.3.4.4b, in a common bottlenose dolphin (Tursiops truncatus) from Florida, United States. Pathological findings include neuronal necrosis and inflammation of the brain and meninges, and quantitative real time RT-PCR reveal the brain carried the highest viral load. Virus isolated from the brain contains a S246N neuraminidase substitution which leads to reduced inhibition by neuraminidase inhibitor oseltamivir. The increased prevalence of A(H5N1) viruses in atypical avian hosts and its cross-species transmission into mammalian species highlights the public health importance of continued disease surveillance and biosecurity protocols.
Identifiants
pubmed: 38637646
doi: 10.1038/s42003-024-06173-x
pii: 10.1038/s42003-024-06173-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
476Informations de copyright
© 2024. The Author(s).
Références
PLoS Pathog. 2023 Mar 10;19(3):e1011214
pubmed: 36897923
Emerg Microbes Infect. 2022 Dec;11(1):725-729
pubmed: 35172704
Emerg Infect Dis. 2023 Apr;29(4):786-791
pubmed: 36958010
Anal Biochem. 1979 Apr 15;94(2):287-96
pubmed: 464297
Sci Rep. 2020 Mar 24;10(1):5359
pubmed: 32210274
Virology. 2023 Oct;587:109860
pubmed: 37572517
Bull World Health Organ. 1978;56(6):923-30
pubmed: 310734
Emerg Infect Dis. 2015 Apr;21(4):720-2
pubmed: 25811303
PLoS One. 2015 Dec 14;10(12):e0144899
pubmed: 26658347
Sci Rep. 2022 Jul 11;12(1):11729
pubmed: 35821511
J Virol. 2016 Apr 14;90(9):4269-4277
pubmed: 26819311
Arch Virol. 2001 Dec;146(12):2275-89
pubmed: 11811679
mBio. 2012 Jul 31;3(4):e00166-12
pubmed: 22851656
Nat Commun. 2023 Sep 7;14(1):5489
pubmed: 37679333
Emerg Infect Dis. 2023 Apr;29(4):852-855
pubmed: 36918379
J Wildl Dis. 2001 Oct;37(4):820-5
pubmed: 11763748
Microbiol Spectr. 2023 Feb 14;11(1):e0286722
pubmed: 36688676
Science. 2007 Aug 10;317(5839):825-8
pubmed: 17690300
Virology. 1981 Sep;113(2):712-24
pubmed: 6267805
Am J Pathol. 2006 Jan;168(1):176-83; quiz 364
pubmed: 16400021
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
PLoS Pathog. 2009 Dec;5(12):e1000709
pubmed: 20041223
J Comp Pathol. 2007 Aug-Oct;137(2-3):155-9
pubmed: 17689552
J Virol. 1986 May;58(2):655-6
pubmed: 3701925
Ecohealth. 2016 Mar;13(1):161-70
pubmed: 25231137
Emerg Microbes Infect. 2023 Dec;12(1):2186608
pubmed: 36880345
Emerg Microbes Infect. 2016 Aug 03;5(8):e81
pubmed: 27485496
Infect Genet Evol. 2014 Jun;24:183-6
pubmed: 24704761
Avian Dis. 2012 Mar;56(1):144-52
pubmed: 22545540
Antiviral Res. 2021 Oct;194:105158
pubmed: 34363859
J Virol. 1984 Sep;51(3):863-5
pubmed: 6471169