Cellular therapeutics and immunotherapies in wound healing - on the pulse of time?
Biofilm
Cellular therapies
Chronic wounds
Immunotherapies
Wound healing
Wound healing disorder
Journal
Military Medical Research
ISSN: 2054-9369
Titre abrégé: Mil Med Res
Pays: England
ID NLM: 101643181
Informations de publication
Date de publication:
18 Apr 2024
18 Apr 2024
Historique:
received:
04
09
2023
accepted:
10
04
2024
medline:
19
4
2024
pubmed:
19
4
2024
entrez:
18
4
2024
Statut:
epublish
Résumé
Chronic, non-healing wounds represent a significant challenge for healthcare systems worldwide, often requiring significant human and financial resources. Chronic wounds arise from the complex interplay of underlying comorbidities, such as diabetes or vascular diseases, lifestyle factors, and genetic risk profiles which may predispose extremities to local ischemia. Injuries are further exacerbated by bacterial colonization and the formation of biofilms. Infection, consequently, perpetuates a chronic inflammatory microenvironment, preventing the progression and completion of normal wound healing. The current standard of care (SOC) for chronic wounds involves surgical debridement along with localized wound irrigation, which requires inpatient care under general anesthesia. This could be followed by, if necessary, defect coverage via a reconstructive ladder utilizing wound debridement along with skin graft, local, or free flap techniques once the wound conditions are stabilized and adequate blood supply is restored. To promote physiological wound healing, a variety of approaches have been subjected to translational research. Beyond conventional wound healing drugs and devices that currently supplement treatments, cellular and immunotherapies have emerged as promising therapeutics that can behave as tailored therapies with cell- or molecule-specific wound healing properties. However, in contrast to the clinical omnipresence of chronic wound healing disorders, there remains a shortage of studies condensing the current body of evidence on cellular therapies and immunotherapies for chronic wounds. This review provides a comprehensive exploration of current therapies, experimental approaches, and translational studies, offering insights into their efficacy and limitations. Ultimately, we hope this line of research may serve as an evidence-based foundation to guide further experimental and translational approaches and optimize patient care long-term.
Identifiants
pubmed: 38637905
doi: 10.1186/s40779-024-00528-5
pii: 10.1186/s40779-024-00528-5
pmc: PMC11025282
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
23Subventions
Organisme : German research foundation (DFG)
ID : Walter Benjamin Fellowship
Informations de copyright
© 2024. The Author(s).
Références
Cancers (Basel). 2020 Sep 24;12(10):
pubmed: 32987790
Methods Mol Biol. 2012;844:139-56
pubmed: 22262440
J Foot Ankle Res. 2020 Mar 24;13(1):16
pubmed: 32209136
Int J Low Extrem Wounds. 2009 Mar;8(1):11-8
pubmed: 19189997
Stem Cells Int. 2018 May 20;2018:6901983
pubmed: 29887893
J Wound Ostomy Continence Nurs. 2013 Nov-Dec;40(6):585-9
pubmed: 24202221
Int Wound J. 2006 Sep;3(3):171-9
pubmed: 16984574
Immunobiology. 2013 Apr;218(4):455-64
pubmed: 22749980
J Control Release. 2022 Jul;347:379-388
pubmed: 35550914
Expert Opin Biol Ther. 2019 Jun;19(6):575-585
pubmed: 30900481
Rheumatology (Oxford). 2019 Dec 1;58(Suppl 7):vii7-vii16
pubmed: 31816085
Mayo Clin Proc. 2021 Sep;96(9):2407-2417
pubmed: 34226023
Nat Immunol. 2003 Apr;4(4):337-42
pubmed: 12612581
Hum Immunol. 2005 Mar;66(3):222-30
pubmed: 15784460
Science. 2003 Feb 14;299(5609):1057-61
pubmed: 12522256
Int J Biol Sci. 2022 Jul 4;18(11):4388-4399
pubmed: 35864974
Mar Drugs. 2018 Feb 09;16(2):
pubmed: 29425164
Wound Repair Regen. 2013 Jan-Feb;21(1):44-54
pubmed: 23126541
Cell. 2021 Jul 22;184(15):3852-3872
pubmed: 34297930
Theranostics. 2017 Jan 1;7(1):81-96
pubmed: 28042318
mSphere. 2022 Jun 29;7(3):e0013022
pubmed: 35642538
Front Immunol. 2022 Sep 30;13:1012647
pubmed: 36248909
Stem Cells Transl Med. 2023 Jan 30;12(1):17-25
pubmed: 36571216
J Biomed Sci. 2020 Jan 2;27(1):1
pubmed: 31894001
Am J Transl Res. 2022 Jun 15;14(6):3879-3892
pubmed: 35836896
Nat Rev Immunol. 2020 Mar;20(3):158-172
pubmed: 31811270
Ann N Y Acad Sci. 2020 Feb;1462(1):27-36
pubmed: 31655007
Diabetes Care. 1998 May;21(5):822-7
pubmed: 9589248
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Wound Repair Regen. 2012 Jan-Feb;20(1):38-49
pubmed: 22151742
Front Med (Lausanne). 2023 Feb 15;10:1015711
pubmed: 36873870
Am J Pathol. 2011 Nov;179(5):2220-32
pubmed: 21945411
Adv Wound Care (New Rochelle). 2015 Sep 1;4(9):534-544
pubmed: 26339532
Plast Reconstr Surg. 2006 Jun;117(7):2284-91
pubmed: 16772930
Eur J Med Res. 2023 Apr 25;28(1):157
pubmed: 37098583
Adv Wound Care (New Rochelle). 2019 Sep 1;8(9):417-428
pubmed: 31440419
Trends Mol Med. 2017 Feb;23(2):135-149
pubmed: 28126271
Front Immunol. 2023 Feb 15;14:1085742
pubmed: 36875129
Biology (Basel). 2023 Mar 20;12(3):
pubmed: 36979163
Orthop Rev (Pavia). 2022 Aug 25;14(3):37498
pubmed: 36034728
Mil Med Res. 2023 Aug 17;10(1):36
pubmed: 37587531
J Funct Biomater. 2018 Jan 18;9(1):
pubmed: 29346333
Surg Clin North Am. 2020 Aug;100(4):681-693
pubmed: 32681869
Nat Commun. 2021 Jun 7;12(1):3363
pubmed: 34099651
Ann Biomed Eng. 2013 Mar;41(3):598-609
pubmed: 23149904
J Control Release. 2023 Oct;362:513-523
pubmed: 37666301
Mater Horiz. 2023 Nov 27;10(12):5500-5507
pubmed: 37815454
Mol Ther. 2022 Sep 7;30(9):2891-2908
pubmed: 35918892
World J Stem Cells. 2020 Jul 26;12(7):659-675
pubmed: 32843920
FASEB J. 2020 Feb;34(2):2213-2226
pubmed: 31907984
Wound Repair Regen. 2012 Mar-Apr;20(2):185-93
pubmed: 22332749
Am J Transl Res. 2020 Jun 15;12(6):2652-2663
pubmed: 32655797
Front Cell Dev Biol. 2023 Jan 30;10:1081644
pubmed: 36794233
Stem Cell Res Ther. 2022 Jan 24;13(1):24
pubmed: 35073970
Clin Microbiol Rev. 2001 Apr;14(2):244-69
pubmed: 11292638
Pflugers Arch. 2017 Apr;469(3-4):365-374
pubmed: 28185068
Microorganisms. 2022 Apr 05;10(4):
pubmed: 35456825
Eur J Immunol. 2018 Jun;48(6):1001-1013
pubmed: 29457218
Platelets. 2018 Jul;29(5):468-475
pubmed: 28727481
Adv Wound Care (New Rochelle). 2014 Jul 1;3(7):482-491
pubmed: 25032068
J Wound Care. 2017 Jan 2;26(1):20-25
pubmed: 28103163
Antimicrob Agents Chemother. 2015 Jan;59(1):299-309
pubmed: 25348518
Adv Wound Care (New Rochelle). 2021 Nov;10(11):596-622
pubmed: 33086946
Wound Repair Regen. 2022 Mar;30(2):156-171
pubmed: 35130362
J Immunol. 2021 Mar 15;206(6):1204-1214
pubmed: 33504617
Syst Rev. 2017 Jan 24;6(1):15
pubmed: 28118847
Biosci Rep. 2017 Apr 10;37(2):
pubmed: 28246352
Immunity. 2013 Feb 21;38(2):275-84
pubmed: 23333074
J Immunol. 2016 Mar 1;196(5):2010-4
pubmed: 26826250
Laryngoscope. 2019 Dec;129(12):E428-E433
pubmed: 31074843
Tissue Eng. 2007 Jun;13(6):1299-312
pubmed: 17518741
Regen Med. 2018 Jul 1;13(5):491-495
pubmed: 30062921
Adv Wound Care (New Rochelle). 2016 Feb 1;5(2):79-88
pubmed: 26862465
Wounds. 2017 Jun;29(6):S1-S17
pubmed: 28682297
Br J Haematol. 2017 Jul;178(2):209-219
pubmed: 28419428
Circ Res. 2007 Jan 5;100(1):27-40
pubmed: 17204662
J Invest Dermatol. 2022 Jan;142(1):220-231.e8
pubmed: 34293353
Int Wound J. 2013 Apr;10(2):132-7
pubmed: 23506344
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):87-96
pubmed: 33028092
NPJ Regen Med. 2021 Jun 17;6(1):35
pubmed: 34140525
J Immunol. 2013 Sep 15;191(6):3049-56
pubmed: 23940277
Stem Cell Res Ther. 2019 Feb 26;10(1):68
pubmed: 30808416
Clin Exp Immunol. 2023 Mar 16;211(2):96-107
pubmed: 35960852
Antimicrob Agents Chemother. 2018 Feb 23;62(3):
pubmed: 29311091
Nat Rev Immunol. 2014 Jun;14(6):417-28
pubmed: 24854591
Regen Med. 2020 Feb;15(2):1277-1293
pubmed: 32228292
Ann Plast Surg. 2019 Dec;83(6):e96-e109
pubmed: 31335465
J Clin Orthop Trauma. 2021 Jul 28;21:101534
pubmed: 34386346
Science. 2018 Oct 12;362(6411):154-155
pubmed: 30309932
Mil Med Res. 2023 Oct 23;10(1):49
pubmed: 37867188
Cell Tissue Bank. 2015 Mar;16(1):19-26
pubmed: 24651970
Int Wound J. 2020 Feb;17(1):55-64
pubmed: 31729833
Adv Ther. 2017 Mar;34(3):599-610
pubmed: 28108895
Appl Environ Microbiol. 2016 Feb 12;82(7):2219-26
pubmed: 26873320
Adv Wound Care (New Rochelle). 2015 Sep 1;4(9):560-582
pubmed: 26339534
Head Neck. 2021 May;43(5):1509-1520
pubmed: 33417293
Molecules. 2017 Jul 27;22(8):
pubmed: 28749427
Semin Plast Surg. 2021 Aug;35(3):171-180
pubmed: 34526865
Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13505-10
pubmed: 19666581
Int J Mol Sci. 2022 Jul 28;23(15):
pubmed: 35955503
Arch Dermatol Res. 2023 Jul;315(5):1249-1255
pubmed: 36520210
Tissue Eng Part B Rev. 2017 Feb;23(1):83-99
pubmed: 27672729
J Cutan Med Surg. 2021 Jan-Feb;25(1):59-76
pubmed: 32746624
Diabetes Res Clin Pract. 2013 Oct;102(1):53-9
pubmed: 24011427
Stem Cell Res Ther. 2019 Mar 12;10(1):87
pubmed: 30867069
Sci Rep. 2022 Jul 22;12(1):12519
pubmed: 35869108
Int J Mol Sci. 2022 Apr 28;23(9):
pubmed: 35563319
Nat Commun. 2021 Dec 1;12(1):7005
pubmed: 34853305
Value Health. 2018 Jan;21(1):27-32
pubmed: 29304937
ACS Appl Mater Interfaces. 2022 Oct 26;14(42):47420-47431
pubmed: 36222290
Cell Mol Bioeng. 2023 Apr 8;16(3):231-240
pubmed: 37456784
PLoS One. 2010 Nov 29;5(11):e15521
pubmed: 21170416
J Immunol Res. 2019 Nov 4;2019:1919082
pubmed: 31781673
Stem Cells Transl Med. 2020 Oct;9(10):1218-1232
pubmed: 32534464