Microneedle-mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune-Mediated Alopecia.

autoimmunity drug delivery immunoregulation microneedles skin disorders

Journal

Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358

Informations de publication

Date de publication:
18 Apr 2024
Historique:
revised: 05 04 2024
received: 13 11 2023
medline: 19 4 2024
pubmed: 19 4 2024
entrez: 19 4 2024
Statut: aheadofprint

Résumé

Disorders in the regulatory arm of the adaptive immune system result in autoimmune-mediated diseases. While systemic immunosuppression is the prevailing approach to manage them, it fails to achieve long-lasting remission due to concomitant suppression of the regulatory arm and carries the risk of heightened susceptibility to infections and malignancies. Alopecia Areata is a condition characterized by localized hair loss due to autoimmunity. The accessibility of the skin provides an opportunity for local rather than systemic intervention to avoid broad immunosuppression. We hypothesized that expansion of endogenous regulatory T cells (T

Identifiants

DOI: 10.1002/adma.202312088 PMID: 38638030
pubmed: 38638030
doi: 10.1002/adma.202312088
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2312088

Informations de copyright

This article is protected by copyright. All rights reserved.

Auteurs

Nour Younis (N)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Núria Puigmal (N)

Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, USA.
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

Abdallah El Kurdi (AE)

Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

Andrew Badaoui (A)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Dongliang Zhang (D)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Claudia Morales (C)

Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, USA.

Anis Saad (A)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Diane Cruz (D)

Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, USA.

Nadim Al Rahy (NA)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Andrea Daccache (A)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Triana Huerta (T)

Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, USA.

Christa Deban (C)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Ahmad Halawi (A)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

John Choi (J)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Pere Dosta (P)

Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, USA.
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

Christine Lian (C)

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Natalie Artzi (N)

Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, MA, USA.
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
ORCID: 0000-0002-2211-6069

Jamil R Azzi (JR)

Brigham and Woman's Hospital, Department of Medicine, Renal Division, Harvard Medical School, Boston, MA, USA.

Classifications MeSH