Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain.
Esculin
Parkinson’s disease
brain targeting
intravitreal injection
microspheres
Journal
Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665
Informations de publication
Date de publication:
19 Apr 2024
19 Apr 2024
Historique:
medline:
19
4
2024
pubmed:
19
4
2024
entrez:
19
4
2024
Statut:
aheadofprint
Résumé
This study explored the distribution of esculin microspheres in rabbit brain tissue following intravitreal injection and investigated the possibility of direct entry of the drug into the brain through the eye, to develop a formulation with enhanced therapeutic efficacy against Parkinson's disease.Chitosan microspheres of esculin were prepared
Identifiants
pubmed: 38638108
doi: 10.1080/00498254.2024.2341402
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM