Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study.
Acute pain
Dermatitis
Head and neck cancer
Oral Cavity and oropharyngeal cancer
Oral mucositis
Radiation Therapy
Journal
Oral oncology reports
ISSN: 2772-9060
Titre abrégé: Oral Oncol Rep
Pays: England
ID NLM: 9918681183706676
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
19
4
2024
pubmed:
19
4
2024
entrez:
19
4
2024
Statut:
ppublish
Résumé
Pain during Radiation Therapy (RT) for oral cavity/oropharyngeal cancer (OC/OPC) is a clinical challenge due to its multifactorial etiology and variable management. The objective of this study was to define complex pain profiles through temporal characterization of pain descriptors, physiologic state, and RT-induced toxicities for pain trajectories understanding. Using an electronic health record registry, 351 OC/OPC patients treated with RT from 2013 to 2021 were included. Weekly numeric scale pain scores, pain descriptors, vital signs, physician-reported toxicities, and analgesics were analyzed using linear mixed effect models and Spearman's correlation. Area under the pain curve (AUC Median pain scores increased from 0 during the weekly visit (WSV)-1 to 5 during WSV-7. By WSV-7, 60% and 74% of patients reported mouth and throat pain, respectively, with a median pain score of 5. Soreness and burning pain peaked during WSV-6/7 (51%). Median AUC This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.
Identifiants
pubmed: 38638130
doi: 10.1016/j.oor.2023.100092
pmc: PMC11025722
mid: NIHMS1962759
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIDCR NIH HHS
ID : K01 DE030524
Pays : United States
Organisme : NCI NIH HHS
ID : K12 CA088084
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028290
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA261856
Pays : United States
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