Low dose aspirin prevents endothelial dysfunction in the aorta and foetal loss in pregnant mice infected with influenza A virus.

aspirin foetal influenza pregnancy vascular dysfunction

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2024
Historique:
received: 29 01 2024
accepted: 15 03 2024
medline: 19 4 2024
pubmed: 19 4 2024
entrez: 19 4 2024
Statut: epublish

Résumé

Influenza A virus (IAV) infection in pregnancy resembles a preeclamptic phenotype characterised by vascular dysfunction and foetal growth retardation. Given that low dose aspirin (ASA) is safe in pregnancy and is used to prevent preeclampsia, we investigated whether ASA or NO-conjugated aspirin, NCX4016, resolve vascular inflammation and function to improve offspring outcomes following IAV infection in pregnant mice. Pregnant mice were intranasally infected with a mouse adapted IAV strain (Hkx31; 10

Identifiants

DOI: 10.3389/fimmu.2024.1378610 PMID: 38638436 PMC: PMC11024306
pubmed: 38638436
doi: 10.3389/fimmu.2024.1378610
pmc: PMC11024306
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1378610

Informations de copyright

Copyright © 2024 Coward-Smith, Liong, Oseghale, Erlich, Miles, Liong, Brassington, Bozinovski, Vlahos, Brooks, Brooks, O’Leary and Selemidis.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Basic Res Cardiol. 1999 Oct;94(5):295-314
pubmed: 10543305
Int J Mol Sci. 2021 Apr 08;22(8):
pubmed: 33917744
PeerJ. 2021 Aug 03;9:e11892
pubmed: 34414033
Nat Commun. 2021 Aug 16;12(1):4957
pubmed: 34400653
Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d
pubmed: 21890489
Am J Obstet Gynecol. 2017 Feb;216(2):110-120.e6
pubmed: 27640943
AJOG Glob Rep. 2021 Feb;1(1):
pubmed: 34085052
Adv Neurol. 2001;86:91-104
pubmed: 11554013
Cancer Metastasis Rev. 2017 Jun;36(2):289-303
pubmed: 28762014
Public Health Res Pract. 2022 Jun 15;32(2):
pubmed: 35702753
Cardiovasc J Afr. 2016 Mar-Apr;27(2):89-94
pubmed: 27213856
Best Pract Res Clin Obstet Gynaecol. 2021 Oct;76:53-65
pubmed: 33965331
BMJ. 2011 Jun 14;342:d3214
pubmed: 21672992
Front Endocrinol (Lausanne). 2019 Mar 01;10:98
pubmed: 30930847
Int J Infect Dis. 2023 Oct;135:28-40
pubmed: 37516425
BMJ. 2013 Nov 07;347:f6564
pubmed: 24201165
Br Heart J. 1992 Dec;68(6):540-3
pubmed: 1467047
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2860-4
pubmed: 11226331
Influenza Other Respir Viruses. 2017 Jan;11(1):85-92
pubmed: 27542891
Nat Commun. 2017 Jul 12;8(1):69
pubmed: 28701733
Front Physiol. 2014 Oct 10;5:372
pubmed: 25346691
Front Microbiol. 2020 Feb 20;11:214
pubmed: 32153526
Cells. 2024 Jan 06;13(2):
pubmed: 38247805
Sci Rep. 2015 Sep 16;5:13394
pubmed: 26373902
Front Physiol. 2016 Feb 05;7:28
pubmed: 26903878
Ultrasound Obstet Gynecol. 2000 Jan;15(1):19-27
pubmed: 10776008

Auteurs

Madison Coward-Smith (M)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Stella Liong (S)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Osezua Oseghale (O)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Jonathan R Erlich (JR)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Mark A Miles (MA)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Felicia Liong (F)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Kurt Brassington (K)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Steven Bozinovski (S)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Ross Vlahos (R)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Robert D Brooks (RD)

Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.

Doug A Brooks (DA)

Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.

John J O'Leary (JJ)

Discipline of Histopathology, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Sir Patrick Dun's Research Laboratory and the Trinity Translational Medicine Institute (TTMI), St. James's Hospital, Dublin, Ireland.

Stavros Selemidis (S)

Centre for Respiratory Science and Health, School of Health & Biomedical Sciences, Royal Melbourne Institute of Techology (RMIT) University, Melbourne, VIC, Australia.

Classifications MeSH