Diverse potential of secretome from natural killer cells and monocyte-derived macrophages in activating stellate cells.
NASH - non-alcoholic steatohepatitis
NK cells
inflammation
liver fibrosis
monocyte-derived macrophage (MDM)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
31
05
2023
accepted:
04
03
2024
medline:
19
4
2024
pubmed:
19
4
2024
entrez:
19
4
2024
Statut:
epublish
Résumé
Chronic liver diseases, such as non-alcoholic steatohepatitis (NASH)-induced cirrhosis, are characterized by an increasing accumulation of stressed, damaged, or dying hepatocytes. Hepatocyte damage triggers the activation of resident immune cells, such as Kupffer cells (KC), as well as the recruitment of immune cells from the circulation toward areas of inflammation. After infiltration, monocytes differentiate into monocyte-derived macrophages (MoMF) which are functionally distinct from resident KC. We herein aim to compare the
Identifiants
pubmed: 38638443
doi: 10.3389/fimmu.2024.1232070
pmc: PMC11025356
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1232070Informations de copyright
Copyright © 2024 Sauer, Steixner-Kumar, Gabler, Motyka, Rippmann, Brosa, Boettner, Schönberger, Lempp, Frodermann, Simon, Krenkel and Bahrami.
Déclaration de conflit d'intérêts
Author MM is employed by the company Ardigen. Authors JS, AS-K, SG, JR, SB, DB, TS, CL, VF, ES, OK, and EB are employed by the company Boehringer Ingelheim.
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