The effect of multiple sclerosis therapy on gut microbiota dysbiosis: a longitudinal prospective study.
brain gut axis
demyelinating autoimmune disorders
gut microbiota
immunoglobulin Y
immunomodulation
microbiome
multiple sclerosis
Journal
Microbial cell (Graz, Austria)
ISSN: 2311-2638
Titre abrégé: Microb Cell
Pays: Austria
ID NLM: 101632887
Informations de publication
Date de publication:
2024
2024
Historique:
received:
23
08
2023
revised:
27
02
2024
accepted:
01
03
2024
medline:
19
4
2024
pubmed:
19
4
2024
entrez:
19
4
2024
Statut:
epublish
Résumé
Gut microbiota has complex immune functions, related to different pathologies, including multiple sclerosis (MS).This study evaluated the influence of treatments on gut microbiota in people with MS (PwMS). The research comprised 60 participants, including 39 PwMS and 21 healthy controls (HC). Among the PwMS, 20 were prescribed a disease-modifying therapy (DMT), either interferon beta1a or teriflunomide, while 19 received a combination of classical DMT and an immunoglobulin Y (IgY) supplement. For each participant, two sets of gut samples were collected: one at the study's outset and another after two months. Alpha and beta diversity analyses revealed no significant differences between groups. In comparison to the HC, the MS group exhibited an increase in
Identifiants
pubmed: 38638559
doi: 10.15698/mic2024.03.819
pmc: PMC11026063
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106-115Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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