A systematic review and in silico analysis of studies investigating the ischaemic penumbra proteome in animal models of experimental stroke.

Ischaemic stroke animal models cerebral infarction ischaemic penumbra proteomics

Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
19 Apr 2024
Historique:
medline: 19 4 2024
pubmed: 19 4 2024
entrez: 19 4 2024
Statut: aheadofprint

Résumé

Ischaemic stroke results in the formation of a cerebral infarction bordered by an ischaemic penumbra. Characterising the proteins within the ischaemic penumbra may identify neuro-protective targets and novel circulating markers to improve patient care. This review assessed data from studies using proteomic platforms to compare ischaemic penumbra tissues to controls following experimental stroke in animal models. Proteins reported to differ significantly between penumbra and control tissues were analysed

Identifiants

DOI: 10.1177/0271678X241248502 PMID: 38639008
pubmed: 38639008
doi: 10.1177/0271678X241248502
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

271678X241248502

Déclaration de conflit d'intérêts

Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Auteurs

Joseph V Moxon (JV)

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Australia.
Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Australia.
Centre for Tropical Bioinformatics and Molecular Biology, James Cook University, Townsville, Australia.
College of Medicine and Dentistry, James Cook University, Townsville, Australia.

Cornea Pretorius (C)

Townsville University Hospital, Angus Smith Drive, Douglas, Townsville, Australia.

Alexandra F Trollope (AF)

Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Australia.
College of Medicine and Dentistry, James Cook University, Townsville, Australia.

Parul Mittal (P)

Mass Spectrometry and Proteomics Group, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.
ORCID: 0000-0003-0139-9757

Manuela Klingler-Hoffmann (M)

Mass Spectrometry and Proteomics Group, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.

Peter Hoffmann (P)

Mass Spectrometry and Proteomics Group, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, Australia.

Jonathan Golledge (J)

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Australia.
Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Australia.
Department of Vascular and Endovascular Surgery, Townsville University Hospital, Townsville, Australia.

Classifications MeSH