IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4
Antigen-specific T cells
COVID-19
IL-1 receptors
IL-1β
Primary antibody deficiency
mRNA vaccines
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
18 Apr 2024
18 Apr 2024
Historique:
received:
06
11
2023
revised:
21
03
2024
accepted:
29
03
2024
medline:
20
4
2024
pubmed:
20
4
2024
entrez:
19
4
2024
Statut:
aheadofprint
Résumé
The innate immune cytokine interleukin (IL)-1 can affect T cell immunity, a critical factor in host defense. In a previous study, we identified a subset of human CD4 We characterized CD4 In healthy individuals, CD4 Our results demonstrate the significance of IL-1R1 expression in CD4 Moderna to HJP, National Institutes of Health (NIH) 1R01AG056728 and R01AG055362 to IK and KL2 TR001862 to JJS, Quest Diagnostics to IK and RB, and the Mathers Foundation to RB.
Sections du résumé
BACKGROUND
BACKGROUND
The innate immune cytokine interleukin (IL)-1 can affect T cell immunity, a critical factor in host defense. In a previous study, we identified a subset of human CD4
METHODS
METHODS
We characterized CD4
FINDINGS
RESULTS
In healthy individuals, CD4
INTERPRETATION
CONCLUSIONS
Our results demonstrate the significance of IL-1R1 expression in CD4
FUNDING
BACKGROUND
Moderna to HJP, National Institutes of Health (NIH) 1R01AG056728 and R01AG055362 to IK and KL2 TR001862 to JJS, Quest Diagnostics to IK and RB, and the Mathers Foundation to RB.
Identifiants
pubmed: 38640835
pii: S2352-3964(24)00149-X
doi: 10.1016/j.ebiom.2024.105114
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105114Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests MKR is an employee of Quest Diagnostics. IK and RB received research funding from Quest Diagnostics.