Insights Into Differences in Pulmonary Hemodynamics in Hispanic Patients With Pulmonary Arterial Hypertension.
Hispanic
Phenotypes
Pulmonary arterial hemodynamics
Pulmonary arterial hypertension
Journal
Cardiology research
ISSN: 1923-2829
Titre abrégé: Cardiol Res
Pays: Canada
ID NLM: 101557543
Informations de publication
Date de publication:
Apr 2024
Apr 2024
Historique:
received:
18
01
2024
accepted:
01
03
2024
medline:
22
4
2024
pubmed:
22
4
2024
entrez:
22
4
2024
Statut:
ppublish
Résumé
Emerging data suggest that Hispanic patients with pulmonary arterial hypertension (PAH) exhibit improved survival rates compared to individuals of other ethnicities with similar baseline hemodynamics. However, the underlying reasons for this survival advantage remain unclear. This study focused on comparing pulmonary hemodynamics in Hispanic and non-Hispanic PAH patients and how these differences may contribute to varied clinical outcomes. A retrospective analysis of right heart catheterization data was conducted on a treatment-naive PAH patient cohort from a single center. Over a 10-year period, a total of 226 PAH patients were identified, of which 138 (61%) were Hispanic and 88 (39%) were non-Hispanic. Hispanic patients presented with lower pulmonary artery pressures, lower pulmonary vascular resistance, and exhibited significantly higher pulmonary arterial compliance (PAc). Hispanic patients had better 5-year survival rates. This study highlights the importance of exploring phenotypic differences in ethnically diverse PAH cohorts.
Sections du résumé
Background
UNASSIGNED
Emerging data suggest that Hispanic patients with pulmonary arterial hypertension (PAH) exhibit improved survival rates compared to individuals of other ethnicities with similar baseline hemodynamics. However, the underlying reasons for this survival advantage remain unclear. This study focused on comparing pulmonary hemodynamics in Hispanic and non-Hispanic PAH patients and how these differences may contribute to varied clinical outcomes.
Methods
UNASSIGNED
A retrospective analysis of right heart catheterization data was conducted on a treatment-naive PAH patient cohort from a single center.
Results
UNASSIGNED
Over a 10-year period, a total of 226 PAH patients were identified, of which 138 (61%) were Hispanic and 88 (39%) were non-Hispanic. Hispanic patients presented with lower pulmonary artery pressures, lower pulmonary vascular resistance, and exhibited significantly higher pulmonary arterial compliance (PAc). Hispanic patients had better 5-year survival rates.
Conclusions
UNASSIGNED
This study highlights the importance of exploring phenotypic differences in ethnically diverse PAH cohorts.
Identifiants
pubmed: 38645831
doi: 10.14740/cr1618
pmc: PMC11027778
doi:
Types de publication
Journal Article
Langues
eng
Pagination
117-124Informations de copyright
Copyright 2024, Fadah et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.