Whole-brain deuterium metabolic imaging via concentric ring trajectory readout enables assessment of regional variations in neuronal glucose metabolism.
3D magnetic resonance spectroscopic imaging
deuterium metabolic imaging
deuterium‐labeled glucose
downstream neurotransmitter synthesis
whole‐brain metabolic mapping
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 Apr 2024
15 Apr 2024
Historique:
revised:
13
03
2024
received:
27
01
2024
accepted:
04
04
2024
medline:
23
4
2024
pubmed:
23
4
2024
entrez:
22
4
2024
Statut:
ppublish
Résumé
Deuterium metabolic imaging (DMI) is an emerging magnetic resonance technique, for non-invasive mapping of human brain glucose metabolism following oral or intravenous administration of deuterium-labeled glucose. Regional differences in glucose metabolism can be observed in various brain pathologies, such as Alzheimer's disease, cancer, epilepsy or schizophrenia, but the achievable spatial resolution of conventional phase-encoded DMI methods is limited due to prolonged acquisition times rendering submilliliter isotropic spatial resolution for dynamic whole brain DMI not feasible. The purpose of this study was to implement non-Cartesian spatial-spectral sampling schemes for whole-brain
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e26686Subventions
Organisme : NIH HHS
ID : R01EB031787
Pays : United States
Organisme : Wellcome Trust
ID : 225924/Z/22/Z
Pays : United Kingdom
Informations de copyright
© 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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