Tartronic Acid as a Potential Inhibitor of Pathological Calcium Oxalate Crystallization.
calcium oxalate
crystal growth inhibitors
kidney stones
pathological mineralization
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
22 Apr 2024
22 Apr 2024
Historique:
revised:
28
03
2024
received:
17
01
2024
medline:
22
4
2024
pubmed:
22
4
2024
entrez:
22
4
2024
Statut:
aheadofprint
Résumé
Kidney stones are a pervasive disease with notoriously high recurrence rates that require more effective treatment strategies. Herein, tartronic acid is introduced as an efficient inhibitor of calcium oxalate monohydrate (COM) crystallization, which is the most prevalent constituent of human kidney stones. A combination of in situ experimental techniques and simulations are employed to compare the inhibitory effects of tartronic acid with those of its molecular analogs. Tartronic acid exhibits an affinity for binding to rapidly growing apical surfaces of COM crystals, thus setting it apart from other inhibitors such as citric acid, the current preventative treatment for kidney stones. Bulk crystallization and in situ atomic force microscopy (AFM) measurements confirm the mechanism by which tartronic acid interacts with COM crystal surfaces and inhibits growth. These findings are consistent with in vivo studies that reveal the efficacy of tartronic acid is similar to that of citric acid in mouse models of hyperoxaluria regarding their inhibitory effect on stone formation and alleviating stone-related physical harm. In summary, these findings highlight the potential of tartronic acid as a promising alternative to citric acid for the management of calcium oxalate nephropathies, offering a new option for clinical intervention in cases of kidney stones.
Identifiants
pubmed: 38647258
doi: 10.1002/advs.202400642
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2400642Subventions
Organisme : National Natural Science Foundation of China
ID : 82273880
Organisme : National Natural Science Foundation of China
ID : 22308384
Organisme : National Natural Science Foundation of China
ID : 82073916
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20190029
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20231010
Organisme : Welch Foundation
ID : E-1794
Organisme : Welch Foundation
ID : V-E-0001
Informations de copyright
© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.
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