A Dynamic Ultrasound Phantom with Tissue-Mimicking Mechanical and Acoustic Properties.
dynamic bladder phantom
human‐sized torso tank
mechanical and acoustic properties matching
tissue‐mimicking materials
ultrasound imaging
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
22 Apr 2024
22 Apr 2024
Historique:
revised:
25
03
2024
received:
08
01
2024
medline:
22
4
2024
pubmed:
22
4
2024
entrez:
22
4
2024
Statut:
aheadofprint
Résumé
Tissue-mimicking phantoms are valuable tools that aid in improving the equipment and training available to medical professionals. However, current phantoms possess limited utility due to their inability to precisely simulate multiple physical properties simultaneously, which is crucial for achieving a system understanding of dynamic human tissues. In this work, novel materials design and fabrication processes to produce various tissue-mimicking materials (TMMs) for skin, adipose, muscle, and soft tissue at a human scale are developed. Target properties (Young's modulus, density, speed of sound, and acoustic attenuation) are first defined for each TMM based on literature. Each TMM recipe is developed, associated mechanical and acoustic properties are characterized, and the TMMs are confirmed to have comparable mechanical and acoustic properties with the corresponding human tissues. Furthermore, a novel sacrificial core to fabricate a hollow, ellipsoid-shaped bladder phantom complete with inlet and outlet tubes, which allow liquids to flow through and expand this phantom, is adopted. This dynamic bladder phantom with realistic mechanical and acoustic properties to human tissues in combination with the developed skin, soft tissue, and subcutaneous adipose tissue TMMs, culminates in a human scale torso tank and electro-mechanical system that can be systematically utilized for characterizing various medical imaging devices.
Identifiants
pubmed: 38647427
doi: 10.1002/advs.202400271
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2400271Subventions
Organisme : MIT Media Lab
ID : Consortium Funding
Informations de copyright
© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.
Références
S. Shellikeri, S. J. Back, L. Poznick, K. Darge, Ultrasonud Med. Biol. 2018, 44, 1918.
O. t. A. Ejofodomi, V. Zderic, J. M. Zara, Med. Phys. 2010, 37, 1440.
S. P. Grogan, C. A. Mount, Ultrasound Physics and Instrumentation, StatPearls Publishing, Treasure Island, FL, USA 2023.
S. Korossis, F. Bolland, E. Ingham, J. Fisher, J. Kearney, J. Southgate, Tissue Eng. 2006, 12, 635.
E. S. Lukacz, C. Sampselle, M. Gray, S. Macdiarmid, M. Rosenberg, P. Ellsworth, M. H. Palmer, Int J Clin Pract 2011, 65, 1026.
D. E. Irwin, Z. S. Kopp, B. Agatep, I. Milsom, P. Abrams, BJU Int 2011, 108, 1132.
N. N. Maserejian, S. Chen, G. R. Chiu, C. G. Wager, V. Kupelian, A. B. Araujo, J. B. McKinlay, Urology 2013, 82, 560.
M. A. Sepahi, M. Mosavimovahed, Med. J. Islam Repub. Iran. 2021, 35, 1182.
L. Ballstaedt, B. Woodbury, Bladder Post Void Residual Volume, StatPearls Publishing, Treasure Island, FL, USA 2023.
L. Zhang, C. Marcus, D. Lin, D. Mejorado, S. J. Schoen, T. T. Pierce, V. Kumar, S. V. Fernandez, D. Hunt, Q. Li, I. I. Shuvo, D. Sadat, W. Du, H. Edenbaum, L. Jin, W. Liu, Y. C. Eldar, F. Li, A. P. Chandrakasan, A. E. Samir, C. Dagdeviren, Nat. Electron. 2023, 7, 77.
M. S. Kavic, JSLS 1997, 1, 101.
R. M. Sturm, E. B. Yerkes, J. L. Nicholas, D. Snow‐Lisy, D. Diaz Saldano, P. L. Gandor, C. G. Halline, I. Rosoklija, K. Rychlik, E. K. Johnson, E. Y. Cheng, J Urol 2017, 198, 422.
W. Du, L. Zhang, E. Suh, D. Lin, C. Marcus, L. Ozkan, A. Ahuja, S. Fernandez, I. I. Shuvo, D. Sadat, W. Liu, F. Li, A. P. Chandrakasan, T. Ozmen, C. Dagdeviren, Sci. Adv. 2023, 9, eadh5325.
C.‐C. Yu, A. Shah, N. Amiri, C. Marcus, M. O. G. Nayeem, A. K. Bhayadia, A. Karami, C. Dagdeviren, Adv. Mater. 2023, 35, 2300066.
C. Wang, X. Chen, L. Wang, M. Makihata, H.‐C. Liu, T. Zhou, X. Zhao, Science 2022, 377, 517.
L. Zhang, W. Du, J.‐H. Kim, C.‐C. Yu, C. Dagdeviren, Adv. Mater., n/a, 2307664.
S. V. Fernandez, F. Cai, S. Chen, E. Suh, J. Tiepelt, R. McIntosh, C. Marcus, D. Acosta, D. Mejorado, C. Dagdeviren, ACS Biomater. Sci. Eng. 2023, 9, 2070.
NIST, What are imaging phantoms?, accessed.
E. Villa, N. Arteaga‐Marrero, J. González‐Fernández, J. Ruiz‐Alzola, Sci. Rep. 2020, 10, 20401.
S. I. Hernandez‐Torres, E. N. Boice, E. J. Snider, J. Imaging 2022, 8, 270.
S. Nuclear, Virtual human male pelvis phantom.
S. Wognum, S. E. Heethuis, T. Rosario, M. S. Hoogeman, A. Bel, Med. Phys. 2014, 41, 071916.
P. Dahms, L. Dahiya, British J. Urol. 1998, 82, 411.
M. O. Culjat, D. Goldenberg, P. Tewari, R. S. Singh, Ultrasonud Med. Biol. 2010, 36, 861.
A. Keshavarzi, S. Vaezy, P. J. Kaczkowski, G. Keilman, R. Martin, E. Y. Chi, R. Garcia, V. Y. Fujimoto, J. Med. Ultrasound 2001, 20, 473.
I. Foundation, Density, accessed.
J. Ophir, P. Jaeger, Ultrason. Imaging 1982, 4, 163.
H.‐C. Shin, R. Prager, H. Gomersall, N. Kingsbury, G. Treece, A. Gee, Ultrason. Med. Biol. 2010, 36, 623.
A. T. Gray, in Atlas of Ultrasound‐Guided Regional Anesthesia (Third Edition), Chapter 2 – Speed of Sound, Elsevier, Philadelphia, PA, USA 2019, 3.
M. K. Feldman, S. Katyal, M. S. Blackwood, RadioGraphics 2009, 29, 1179.
A. T. Gray, in Atlas of Ultrasound‐Guided Regional Anesthesia (Third Edition), Chapter 3 – Attenuation, Elsevier, Philadelphia, PA, USA 2019, 5.
R. C. Reynolds, Medicina Thoracalis 2009, 22, 161.
A. Samani, J. Zubovits, D. Plewes, Phys. Med. Biol. 2007, 52, 1565.
T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, T. Hall, Ultrason. Imaging 1998, 20, 260.
T. D. Mast, ARLO 2000, 1, 37.
I. Foundation, Speed of sound, accessed.
Y. A. Joarder, K. M. Rahman, F. F. Mahi, 2020.
M. Geerligs, L. van Breemen, G. Peters, P. Ackermans, F. Baaijens, C. Oomens, J. Biomech. 2011, 44, 1176.
J. van Kuilenburg, M. A. Masen, E. van der Heide, Proc. Inst Mech. Eng. J 2013, 227, 349.
H. Azhari, in Basics of Biomedical Ultrasound for Engineers, 2010, 313.
A. I. Chen, M. L. Balter, M. I. Chen, D. Gross, S. K. Alam, T. J. Maguire, M. L. Yarmush, Med. Phys. 2016, 43, 3117.
C. Kuhn, F. Angehrn, O. Sonnabend, A. Voss, Clinical Interventions in Aging 2008, 3, 201.
H. Joodaki, M. B. Panzer, Proc. Inst Mech. Eng. H 2018, 232, 323.
A. Kalra, A. Lowe, A. A. Jumaily, J. Aging Sci. 2016, 4, 156.
P. Sam, A. Nassereddin, C. A. LaGrange, Anatomy, Abdomen and Pelvis: Bladder Detrusor Muscle, StatPearls Publishing, Treasure Island, FL, USA 2023.
C. Richardson, S. Bernard, V. A. Dinh, J. Med. Ultrasound 2015, 34, 1479.
M. Earle, G. D. Portu, E. DeVos, AfJEM 2016, 6, 18.
E. L. Madsen, M. A. Hobson, H. Shi, T. Varghese, G. R. Frank, Phys. Med. Biol. 2005, 50, 5597.
H.‐W. Sung, D.‐M. Huang, W.‐H. Chang, R.‐N. Huang, J.‐C. Hsu, J. Biomed. Mater. Res. 1999, 46, 520.
L. W. Hofstetter, L. Fausett, A. Mueller, H. Odéen, A. Payne, D. A. Christensen, D. L. Parker, Int. J. Hyperthermia 2020, 37, 283.
K. Manickam, R. R. Machireddy, S. Seshadri, J. Mech. Behav. Biomed. Mater. 2014, 35, 132.
E. L. Madsen, G. R. Frank, T. A. Krouskop, T. Varghese, F. Kallel, J. Ophir, Ultrason. Imaging 2003, 25, 17.
G. Y. Liu, R. Agarwal, K. R. Ko, M. Ruthven, H. T. Sarhan, J. P. Frampton, Sci. Rep. 2017, 7, 9628.
J. P. Frampton, D. Lai, M. Lounds, K. Chung, J. Kim, J. F. Mansfield, S. Takayama, Adv. Healthcare Mater. 2015, 4, 313.
R. M. S. Sigrist, J. Liau, A. E. Kaffas, M. C. Chammas, J. K. Willmann, Theranostics 2017, 7, 1303.
W. Lambert, L. A. Cobus, T. Frappart, M. Fink, A. Aubry, Proc. Natl. Acad. Sci. USA 2020, 117, 14645.
G. Cloutier, F. Destrempes, F. Yu, A. Tang, Insights into Imaging 2021, 12, 127.
D. E. Collins, Radiologic Technology 1999, 71, 215.
A. C. Fleischer, National Council on Radiation Protection and Measurements, NCRP Publications, Bethesda, 1983, 26, 213.
A. Fedorov, D. Clunie, E. Ulrich, C. Bauer, A. Wahle, B. Brown, M. Onken, J. Riesmeier, S. Pieper, R. Kikinis, J. Buatti, R. R. Beichel, PeerJ 2016, 4, e2057.
S. Choi, J. R. Moon, N. Park, J. Im, Y. E. Kim, J.‐H. Kim, J. Kim, Adv. Mater. 2023, 35, 2206207.
H. Yuk, T. Zhang, S. Lin, G. A. Parada, X. Zhao, Nat. Mater. 2016, 15, 190.
A. K. Dąbrowska, G.‐M. Rotaru, S. Derler, F. Spano, M. Camenzind, S. Annaheim, R. Stämpfli, M. Schmid, R. M. Rossi, Skin Res. Technol. 2016, 22, 3.
C. K. McGarry, L. J. Grattan, A. M. Ivory, F. Leek, G. P. Liney, Y. Liu, P. Miloro, R. Rai, A. P. Robinson, A. J. Shih, B. Zeqiri, C. H. Clark, Phys. Med. Biol. 2020, 65, 23TR01.
M. Oelke, K. Höfner, U. Jonas, D. Ubbink, J. de la Rosette, H. Wijkstra, Neurourol. Urodyn. 2006, 25, 308.