Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
22 Apr 2024
22 Apr 2024
Historique:
received:
23
02
2024
accepted:
12
04
2024
revised:
15
03
2024
medline:
23
4
2024
pubmed:
23
4
2024
entrez:
22
4
2024
Statut:
epublish
Résumé
Recent research has highlighted the role of complement genes in shaping the microstructure of the brain during early development, and in contributing to common allele risk for Schizophrenia. We hypothesised that common risk variants for schizophrenia within complement genes will associate with structural changes in white matter microstructure within tracts innervating the frontal lobe. Results showed that risk alleles within the complement gene set, but also intergenic alleles, significantly predict axonal density in white matter tracts connecting frontal cortex with parietal, temporal and occipital cortices. Specifically, risk alleles within the Major Histocompatibility Complex region in chromosome 6 appeared to drive these associations. No significant associations were found for the orientation dispersion index. These results suggest that changes in axonal packing - but not in axonal coherence - determined by common risk alleles within the MHC genomic region - including variants related to the Complement system - appear as a potential neurobiological mechanism for schizophrenia.
Identifiants
pubmed: 38649377
doi: 10.1038/s41398-024-02910-2
pii: 10.1038/s41398-024-02910-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
194Subventions
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/L010305/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/P005748/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/T04604X/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/L023784/2
Informations de copyright
© 2024. The Author(s).
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