Computed tomographic features of exocrine pancreatic carcinomas in dogs and cats.
cancer
canine
feline
lymph node
pancreas
Journal
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
ISSN: 1740-8261
Titre abrégé: Vet Radiol Ultrasound
Pays: England
ID NLM: 9209635
Informations de publication
Date de publication:
22 Apr 2024
22 Apr 2024
Historique:
revised:
01
02
2024
received:
24
08
2023
accepted:
26
03
2024
medline:
23
4
2024
pubmed:
23
4
2024
entrez:
23
4
2024
Statut:
aheadofprint
Résumé
Exocrine pancreatic carcinomas are uncommon in dogs and cats, and diagnosis with diagnostic imaging can be challenging. This retrospective, multi-institutional, descriptive study was performed to evaluate the CT features of exocrine pancreatic carcinomas. The CT examinations of 18 dogs and 12 cats with exocrine pancreatic carcinomas diagnosed by cytology or histopathology were reviewed. The CT features of exocrine pancreatic carcinomas included a well-defined mass in 28/30 (93%) with contrast enhancement in 27/30 (90%), commonly heterogeneous 22/30 (73%); often with a nonenhancing fluid to soft tissue attenuating center 12/30 (40%). The right lobe of the pancreas was the most common location, 14/30 (47%), then the left lobe, 10/30 (33%), and the body, 6/30 (20%). Extrahepatic biliary duct dilation was present in six animals; 5/6 (83%) of the masses were located in the right pancreatic lobe. Additional findings included peripancreatic fat-stranding 17/30 (57%), lymphadenopathy 16/30 (57%), peripancreatic soft tissue nodules 12/30 (40%), and free fluid 10/30 (33%). When comparing the imaging features of dogs and cats, there was a large overlap in imaging characteristics. There was a significant difference between the height of the masses, with dogs having larger masses (P-value.0028). Lymphadenopathy was more likely in larger masses [increased height (P-value.029)]. Cats were significantly older than dogs (P-value.0355). Pancreatic carcinomas were commonly identified as masses with heterogeneous contrast enhancement and a nonenhancing fluid to soft tissue attenuating center with concurrent peripancreatic changes (fat-stranding and/or soft tissue nodules) and lymphadenopathy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 The Authors. Veterinary Radiology & Ultrasound published by Wiley Periodicals LLC on behalf of American College of Veterinary Radiology.
Références
Aupperle‐Lellbach H, Törner K, Staudacher M, Müller E, Steiger K, Klopfleisch R. Characterization of 22 canine pancreatic carcinomas and review of literature. J Comp Pathol. 2019; 173:71‐82. doi:10.1016/j.jcpa.2019.10.008
Withrow SJ, Vail DM, Page RL. Exocrine pancreatic carcinoma. Withrow and MacEwen's Small Animal Clinical Oncology. 5th ed. Elsevier Saunders; 2013;
Dennis MM, O'Brien TD, Wayne T, Kiupel M, Williams M, Powers BE. Hyalinizing pancreatic adenocarcinoma in six dogs. Vet Pathol. 2008; 45(4):475‐483. doi:10.1354/vp.45‐4‐475
Pinard CJ, Hocker SE, Weishaar KM. Clinical outcome in 23 dogs with exocrine pancreatic carcinoma. Vet Comp Oncol. 2021; 19(1):109‐114. doi:10.1111/vco.12645
Linderman MJ, Brodsky EM, de Lorimier LP, Clifford CA, Post GS. Feline exocrine pancreatic carcinoma: a retrospective study of 34 cases. Vet Comp Oncol. 2013; 11(3):208‐218. doi:10.1111/j.1476‐5829.2012.00320.x
Hecht S, Penninck DG, Keating JH. Imaging findings in pancreatic neoplasia and nodular hyperplasia in 19 cats. Vet Radiol Ultrasound. 2007; 48(1):45‐50. doi:10.1111/j.1740‐8261.2007.00203.x
Zhao Z, Liu W. Pancreatic cancer: a review of risk factors, diagnosis, and treatment. Technol Cancer Res Treat. 2020; 19:153303382096211. doi:10.1177/1533033820962117
Seaman RL. Exocrine pancreatic neoplasia in the cat: a case series. J Am Anim Hosp Assoc. 2004; 40(3):238‐245. doi:10.5326/0400238
Spain HN, Penninck DG, Webster CR, Daure E, Jennings SH. Ultrasonographic and clinicopathologic features of segmental dilatations of the common bile duct in four cats. JFMS Open Rep. 2017; 3(1):205511691771688. doi:10.1177/2055116917716881. Published 2017 Jun 27.
Park HY, Cho YG, Lee YW, Choi HJ. Evaluation of gallbladder and common bile duct size and appearance by computed tomography in dogs. J Vet Sci. 2018; 19(5):653‐659. doi:10.4142/jvs.2018.19.5.653
Penninck DG, Zeyen U, Taeymans ON, Webster CR. Ultrasonographic measurement of the pancreas and pancreatic duct in clinically normal dogs. Am J Vet Res. 2013; 74(3):433‐437. doi:10.2460/ajvr.74.3.433
Park JY, Bugbee A, Sharma A, Secrest S. Feline pancreatic ducts are consistently identified on CT and more likely to be dilated in the body of pancreas in cats with elevated feline pancreatic lipase immunoreactivity. Vet Radiol Ultrasound. 2020; 61(3):255‐260. doi:10.1111/vru.12834
Teodori S, Aste G, Tamburro R, Morselli‐Labate AM, Simeoni F, Vignoli M. Computed tomography evaluation of normal canine abdominal lymph nodes: retrospective study of size and morphology according to body weight and age in 45 dogs. Vet Sci. 2021; 8(3):44. doi:10.3390/vetsci8030044. Published 2021 Mar 7.
Coss P, Gilman O, Warren‐Smith C, Major AC. The appearance of canine insulinoma on dual phase computed tomographic angiography. J Small Anim Pract. 2021; 62(7):540‐546. doi:10.1111/jsap.13336
Mai W, Cáceres AV. Dual‐phase computed tomographic angiography in three dogs with pancreatic insulinoma. Vet Radiol Ultrasound. 2008; 49(2):141‐148. doi:10.1111/j.1740‐8261.2008.00340.x
Monteiro CB, O'Brien RT. A retrospective study on the sonographic findings of abdominal carcinomatosis in 14 cats. Vet Radiol Ultrasound. 2004; 45(6):559‐564. doi:10.1111/j.1740‐8261.2004.04096.x
Weston PJ, Baines SJ, Finotello R, Mortier JR. Clinical, CT, and ultrasonographic features of canine and feline pleural and peritoneal carcinomatosis and sarcomatosis. Vet Radiol Ultrasound. 2021; 62(3):331‐341. doi:10.1111/vru.12951
Jang S, Lee S, Choi J. CT imaging features of fat stranding in cats and dogs with abdominal disorder. J Vet Sci. 2022; 23(6):e70. doi:10.4142/jvs.22059
Thornton E, Mendiratta‐Lala M, Siewert B, Eisenberg RL. Patterns of fat stranding. AJR Am J Roentgenol. 2011; 197(1):W1‐14. doi:10.2214/AJR.10.4375
Sai M, Mori H, Kiyonaga M, Kosen K, Yamada Y, Matsumoto S. Peripancreatic lymphatic invasion by pancreatic carcinoma: evaluation with multi‐detector row CT. Abdom Imaging. 2010; 35(2):154‐162. doi:10.1007/s00261‐008‐9461‐z