Variable Clinical Courses of Varicella Zoster Virus Infection-related or Vaccination-related Bone Marrow Failure.

Journal

Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928

Informations de publication

Date de publication:
23 Apr 2024
Historique:
received: 31 10 2023
accepted: 21 02 2024
medline: 23 4 2024
pubmed: 23 4 2024
entrez: 23 4 2024
Statut: aheadofprint

Résumé

We report 5 children with bone marrow failure (BMF) after primary varicella zoster virus (VZV) infection or VZV vaccination, highlighting the highly variable course. Two patients were treated with intravenous immunoglobulins; one had a slow hematologic recovery, and the other was rescued by allogeneic hematopoietic stem cell transplantation (HSCT). Of the 2 patients treated with immunosuppressive therapy with antithymocyte globulin and cyclosporine, one had a complete response, and the other was transplanted for nonresponse. One patient underwent a primary allograft. All patients are alive. This study demonstrated that VZV-associated BMF is a life-threatening disorder that often requires HSCT.

Identifiants

DOI: 10.1097/MPH.0000000000002866 PMID: 38652069
pubmed: 38652069
doi: 10.1097/MPH.0000000000002866
pii: 00043426-990000000-00404
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare conflict of interest

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Auteurs

Vasil Toskov (V)

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.

Annamaria Cseh (A)

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.
Department of Stem Cell Transplantation, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.

Alexander Claviez (A)

Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel.

Beatrice Drexler (B)

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.
Department of Medicine, Division of Hematology, University Hospital Basel, Basel, Switzerland.

Natalia Rotari (N)

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.

Stephan Schwarz-Furlan (S)

Institute of Pathology, Klinikum Kaufbeuren-Ravensburg, Kaufbeuren.
Institute of Pathology, University Hospital Erlangen, Erlangen.

Matthias Braun (M)

Department of Padiatrische Hamatologie und Onkologie, Zentrum fur Kinderheiikunde der Justus-Liebig-Universitat Giessen, Giessen.

Peter Bader (P)

Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, University Hospital Frankfurt, Frankfurt am Main.

Peter Lang (P)

Department of Hematology/Oncology and General Pediatrics, Children's University Hospital, University of Tübingen, Tübingen.

Rita Beier (R)

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover.

Bernhard Erdlenbruch (B)

Department of Pediatrics, Johannes Wesling Klinikum Minden, Ruhr-University Bochum, Minden.

Monika Führer (M)

Center for Pediatric Palliative Care, Dr von Hauner Children's Hospital, University of Munich, Munich, Germany.

Miriam Erlacher (M)

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.

Charlotte M Niemeyer (CM)

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.

Brigitte Strahm (B)

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.

Ayami Yoshimi (A)

Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg.

Classifications MeSH