The thrombin receptor PAR4 supports visceral adipose tissue inflammation.
Adipose tissue
Glucose intolerance
Inflammation
Obesity
Protease-activated receptor
Thrombin
Journal
Naunyn-Schmiedeberg's archives of pharmacology
ISSN: 1432-1912
Titre abrégé: Naunyn Schmiedebergs Arch Pharmacol
Pays: Germany
ID NLM: 0326264
Informations de publication
Date de publication:
23 Apr 2024
23 Apr 2024
Historique:
received:
20
03
2024
accepted:
11
04
2024
medline:
23
4
2024
pubmed:
23
4
2024
entrez:
23
4
2024
Statut:
aheadofprint
Résumé
Thrombin inhibition suppresses adiposity, WAT inflammation and metabolic dysfunction in mice. Protease-activated receptor (PAR)1 does not account for thrombin-driven obesity, so we explored the culprit role of PAR4 in this context. Male WT and PAR-4
Identifiants
pubmed: 38652276
doi: 10.1007/s00210-024-03097-5
pii: 10.1007/s00210-024-03097-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01-HL131517, R01-HL136389, R01-HL089598, R01HL163277, R01HL160992
Pays : United States
Informations de copyright
© 2024. The Author(s).
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