Purinergic inhibitory regulation of esophageal smooth muscle is mediated by P2Y receptors and ATP-dependent potassium channels in rats.

ATP-dependent potassium channel Esophagus P2 receptor Purine Smooth muscle

Journal

The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417

Informations de publication

Date de publication:
23 Apr 2024
Historique:
received: 19 09 2023
accepted: 20 03 2024
medline: 24 4 2024
pubmed: 24 4 2024
entrez: 23 4 2024
Statut: epublish

Résumé

Purines such as ATP are regulatory transmitters in motility of the gastrointestinal tract. The aims of this study were to propose functional roles of purinergic regulation of esophageal motility. An isolated segment of the rat esophagus was placed in an organ bath, and mechanical responses were recorded using a force transducer. Exogenous application of ATP (10-100 μM) evoked relaxation of the esophageal smooth muscle in a longitudinal direction under the condition of carbachol (1 μM) -induced precontraction. Pretreatment with a non-selective P2 receptor antagonist, suramin (500 μM), and a P2Y receptor antagonist, cibacron blue F3GA (200 μM), inhibited the ATP (100 μM) -induced relaxation, but a P2X receptor antagonist, pyridoxal phosphate-6-azophenyl-2,4-disulfonic acid (50 μM), did not affect it. A blocker of ATP-dependent potassium channels (K

Identifiants

DOI: 10.1186/s12576-024-00916-5 PMID: 38654149
pubmed: 38654149
doi: 10.1186/s12576-024-00916-5
pii: 10.1186/s12576-024-00916-5
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26

Subventions

Organisme : Grants-in-Aid for Scientific Research (KAKENHI)
ID : 23K05553
Organisme : Grants-in-Aid for Scientific Research (KAKENHI)
ID : 23H00360

Informations de copyright

© 2024. The Author(s).

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Auteurs

Takahiko Shiina (T)

Department of Basic Veterinary Science, Laboratory of Physiology, Joint Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan. shiina.takahiko.a0@f.gifu-u.ac.jp.
Department of Basic Veterinary Science, Laboratory of Physiology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan. shiina.takahiko.a0@f.gifu-u.ac.jp.
ORCID: 0000-0002-3425-950X

Yuji Suzuki (Y)

Department of Basic Veterinary Science, Laboratory of Physiology, Joint Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Kazuhiro Horii (K)

Division of Biological Principles, Department of Physiology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Tomoya Sawamura (T)

Department of Basic Veterinary Science, Laboratory of Physiology, Joint Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Natsufu Yuki (N)

Department of Basic Veterinary Science, Laboratory of Physiology, Joint Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Yuuki Horii (Y)

Institute for Glyco-Core Research (iGCORE), Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.

Yasutake Shimizu (Y)

Department of Basic Veterinary Science, Laboratory of Physiology, Joint Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Department of Basic Veterinary Science, Laboratory of Physiology, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan.
Division of Animal Medical Science, Center for One Medicine Innovative Translational Research (COMIT), Gifu University Institute for Advanced Study, 1-1 Yanagido, Gifu, 501-1193, Japan.

Classifications MeSH