The impact of social-environmental factors on IQ in syndromic intellectual developmental disabilities.
22q11.2 deletion syndrome
Down syndrome
IQ
cognitive development
developmental disabilities
economic stability
environment
fragile x syndrome
genetic syndrome
home environment
intellectual developmental disabilities
parental stress
social determinants of health
social-demographic variables
socioeconomic status
syndromic IDD
Journal
Journal of clinical and translational science
ISSN: 2059-8661
Titre abrégé: J Clin Transl Sci
Pays: England
ID NLM: 101689953
Informations de publication
Date de publication:
2024
2024
Historique:
received:
21
12
2023
revised:
14
03
2024
accepted:
25
03
2024
medline:
24
4
2024
pubmed:
24
4
2024
entrez:
24
4
2024
Statut:
epublish
Résumé
Despite having the same underlying genetic etiology, individuals with the same syndromic form of intellectual developmental disability (IDD) show a large degree of interindividual differences in cognition and IQ. Research indicates that up to 80% of the variation in IQ scores among individuals with syndromic IDDs is attributable to nongenetic effects, including social-environmental factors. In this narrative review, we summarize evidence of the influence that factors related to economic stability (focused on due to its prevalence in existing literature) have on IQ in individuals with syndromic IDDs. We also highlight the pathways through which economic stability is hypothesized to impact cognitive development and drive individual differences in IQ among individuals with syndromic IDDs. We also identify broader social-environmental factors (e.g., social determinants of health) that warrant consideration in future research, but that have not yet been explored in syndromic IDDs. We conclude by making recommendations to address the urgent need for further research into other salient factors associated with heterogeneity in IQ. These recommendations ultimately may shape individual- and community-level interventions and may inform systems-level public policy efforts to promote the cognitive development of and improve the lived experiences of individuals with syndromic IDDs.
Identifiants
pubmed: 38655457
doi: 10.1017/cts.2024.510
pii: S2059866124005107
pmc: PMC11036438
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e59Informations de copyright
© The Author(s) 2024.
Déclaration de conflit d'intérêts
None.
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