Intense pulsed light therapy for ocular surface diseases.


Journal

Lasers in medical science
ISSN: 1435-604X
Titre abrégé: Lasers Med Sci
Pays: England
ID NLM: 8611515

Informations de publication

Date de publication:
24 Apr 2024
Historique:
received: 02 01 2024
accepted: 17 04 2024
medline: 24 4 2024
pubmed: 24 4 2024
entrez: 24 4 2024
Statut: epublish

Résumé

Intense pulsed light (IPL) is a non-laser, high-intensity light source that has been shown to play a valuable role in dermatology and has been adopted in ophthalmology for treating meibomian gland dysfunction (MGD). In this review, we discuss the mechanism of action of IPL, including its benefits in ophthalmology. IPL therapy has been shown to improve tear film stability, meibomian gland (MG) function, and subjective symptoms of ocular dryness in MGD patients. Moreover, emerging evidence suggests that IPL therapy is beneficial for other ocular surface diseases, such as blepharitis and chalazia. Hence, it can be inferred that IPL has potential as a therapeutic modality in future applications. Large clinical and experimental trials are needed to exploit the full potential of IPL as a treatment for recurrent chalazia, Sjögren's syndrome, and other causes of dry eye disease (DED). This paper reviews the published literature related to the application of IPL for treating ocular surface diseases.

Identifiants

pubmed: 38656565
doi: 10.1007/s10103-024-04060-9
pii: 10.1007/s10103-024-04060-9
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

111

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

Références

Raulin C, Greve B, Grema H (2003) IPL technology: a review. Lasers Surg Med 32(2):78–87
pubmed: 12561039 doi: 10.1002/lsm.10145
Kent C (2010) Intense pulsed light: for treating Dry Eye. Review of Ophthalmology
Liu R et al (2017) Analysis of cytokine levels in tears and clinical correlations after intense pulsed light treating Meibomian Gland Dysfunction. Am J Ophthalmol 183:81–90
pubmed: 28887117 doi: 10.1016/j.ajo.2017.08.021
Sagaser S et al (2021) Effects of intense pulsed light on tear Film TGF-beta and Microbiome in Ocular Rosacea with Dry Eye. Clin Ophthalmol 15:323–330
pubmed: 33536740 pmcid: 7850425 doi: 10.2147/OPTH.S280707
Lee H et al (2021) Changes in the expression of matrix metalloproteinase-9 after intense pulsed light therapy combined with meibomian gland expression in moderate and severe meibomian gland dysfunction. Cont Lens Anterior Eye 44(3):101339
pubmed: 32948417 doi: 10.1016/j.clae.2020.05.008
Choi M et al (2019) Meibum Expressibility Improvement as a therapeutic target of intense pulsed light treatment in Meibomian Gland Dysfunction and its association with tear inflammatory cytokines. Sci Rep 9(1):7648
pubmed: 31113979 pmcid: 6529521 doi: 10.1038/s41598-019-44000-0
Byun JY et al (2009) Expression of IL-10, TGF-beta(1) and TNF-alpha in cultured keratinocytes (HaCaT cells) after IPL Treatment or ALA-IPL Photodynamic Treatment. Ann Dermatol 21(1):12–17
pubmed: 20548849 pmcid: 2883362 doi: 10.5021/ad.2009.21.1.12
Taylor M, Porter R, Gonzalez M (2014) Intense pulsed light may improve inflammatory acne through TNF-α down-regulation. J Cosmet Laser Ther 16(2):96–103
pubmed: 24245979 doi: 10.3109/14764172.2013.864198
Wong WR et al (2008) Intense pulsed light modulates the expressions of MMP-2, MMP-14 and TIMP-2 in skin dermal fibroblasts cultured within contracted collagen lattices. J Dermatol Sci 51(1):70–73
pubmed: 18424078 doi: 10.1016/j.jdermsci.2008.02.011
Lee SY et al (2007) A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J Photochem Photobiol B 88(1):51–67
pubmed: 17566756 doi: 10.1016/j.jphotobiol.2007.04.008
De Paiva CS et al (2006) Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res 83(3):526–535
pubmed: 16643899 doi: 10.1016/j.exer.2006.02.004
Aragona P et al (2015) Matrix metalloproteinase 9 and transglutaminase 2 expression at the ocular surface in patients with different forms of dry eye disease. Ophthalmology 122(1):62–71
pubmed: 25240629 doi: 10.1016/j.ophtha.2014.07.048
Anderson RR, Parrish JA (1983) Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220(4596):524–527
pubmed: 6836297 doi: 10.1126/science.6836297
Toyos R, McGill W, Briscoe D (2015) Intense pulsed light treatment for dry eye disease due to meibomian gland dysfunction; a 3-year retrospective study. Photomed Laser Surg 33(1):41–46
pubmed: 25594770 pmcid: 4298157 doi: 10.1089/pho.2014.3819
Piccolo D et al (2014) Unconventional use of intense pulsed light Biomed Res Int, 2014: p. 618206
Vora GK, Gupta PK (2015) Intense pulsed light therapy for the treatment of evaporative dry eye disease. Curr Opin Ophthalmol 26(4):314–318
pubmed: 26058031 doi: 10.1097/ICU.0000000000000166
Yun J, Min JS (2022) Skin temperature change in patients with meibomian gland dysfunction following intense pulsed light treatment. Front Med (Lausanne) 9:893940
pubmed: 36035434 doi: 10.3389/fmed.2022.893940
Seo KY et al (2018) Long-term effects of intense pulsed light treatment on the ocular surface in patients with rosacea-associated meibomian gland dysfunction. Cont Lens Anterior Eye 41(5):430–435
pubmed: 29958778 doi: 10.1016/j.clae.2018.06.002
English FP, Nutting WB (1981) Demodicosis of ophthalmic concern. Am J Ophthalmol 91(3):362–372
pubmed: 7211994 doi: 10.1016/0002-9394(81)90291-9
Dell SJ (2017) Intense pulsed light for evaporative dry eye disease. Clin Ophthalmol 11:1167–1173
pubmed: 28790801 pmcid: 5488788 doi: 10.2147/OPTH.S139894
Kheirkhah A et al (2007) Corneal manifestations of ocular demodex infestation. Am J Ophthalmol 143(5):743–749
pubmed: 17376393 doi: 10.1016/j.ajo.2007.01.054
Zhang XB, Ding YH, He W (2018) The association between demodex infestation and ocular surface manifestations in meibomian gland dysfunction. Int J Ophthalmol 11(4):589–592
pubmed: 29675375 pmcid: 5902361 doi: 10.18240/ijo.2021.04.17
Huo Y et al (2021) Therapeutic effect of intense pulsed light with optimal pulse technology on meibomian gland dysfunction with and without ocular demodex infestation. Ann Transl Med 9(3):238
pubmed: 33708865 pmcid: 7940958 doi: 10.21037/atm-20-1745
Kirn T (2002) Intense Pulsed Light Eradicates Demodex Mites 33(1):37
Fishman HA, Periman LM, Shah AA (2020) Real-time video Microscopy of in Vitro Demodex death by intense pulsed light. Photobiomodul Photomed Laser Surg 38(8):472–476
pubmed: 31985328
Cheng SN et al (2019) Intense pulsed light therapy for patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation. Curr Med Sci 39(5):800–809
pubmed: 31612399 doi: 10.1007/s11596-019-2108-1
Yin Y et al (2018) Changes in the Meibomian Gland after exposure to intense pulsed light in Meibomian Gland Dysfunction (MGD) patients. Curr Eye Res 43(3):308–313
pubmed: 29199865 doi: 10.1080/02713683.2017.1406525
Ahmed SA et al (2019) Effect of intense pulsed light therapy on tear proteins and lipids in Meibomian Gland Dysfunction. J Ophthalmic Vis Res 14(1):3–10
pubmed: 30820280 pmcid: 6388518 doi: 10.4103/jovr.jovr_12_18
Miyamoto M et al (2020) Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease. Elife, 9
Wahlig S, Lovatt M, Mehta JS (2018) Functional role of peroxiredoxin 6 in the eye. Free Radic Biol Med 126:210–220
pubmed: 30120980 doi: 10.1016/j.freeradbiomed.2018.08.017
Zhao H et al (2022) Lipidomics profiles revealed alterations in patients with Meibomian Gland Dysfunction after exposure to intense pulsed light. Front Neurol 13:827544
pubmed: 35242100 pmcid: 8886297 doi: 10.3389/fneur.2022.827544
Karu TI, Kolyakov SF (2005) Exact action spectra for cellular responses relevant to phototherapy. Photomed Laser Surg 23(4):355–361
pubmed: 16144476 doi: 10.1089/pho.2005.23.355
Muste JC, Russell MW, Singh RP (2021) Photobiomodulation Therapy for Age-Related Macular Degeneration and Diabetic Retinopathy: a review. Clin Ophthalmol 15:3709–3720
pubmed: 34511875 pmcid: 8421781 doi: 10.2147/OPTH.S272327
Cardoso FDS, Lopes Martins RAB (2020) Gomes Da Silva, therapeutic potential of Photobiomodulation in Alzheimer’s Disease: a systematic review. J Lasers Med Sci 11(Suppl 1):S16–S22
pubmed: 33995964 pmcid: 7956031 doi: 10.34172/jlms.2020.S3
Markowitz SN et al (2020) A Double-Masked, randomized, Sham-Controlled, single-center study with Photobiomodulation for the Treatment of Dry Age-Related Macular Degeneration. Retina 40(8):1471–1482
pubmed: 31404033 doi: 10.1097/IAE.0000000000002632
Markoulli M, Chandramohan N, Papas EB (2021) Photobiomodulation (low-level light therapy) and dry eye disease. Clin Exp Optom 104(5):561–566
pubmed: 33689636 doi: 10.1080/08164622.2021.1878866
Hong N (2019) Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends. Biomed Eng Lett 9(3):359–366
pubmed: 31456895 pmcid: 6694374 doi: 10.1007/s13534-019-00115-x
Leyane TS, Jere SW, Houreld NN (2021) Cellular Signalling and Photobiomodulation in Chronic Wound Repair. Int J Mol Sci, 22(20)
Mignon C et al (2018) Differential response of human dermal fibroblast subpopulations to visible and near-infrared light: potential of photobiomodulation for addressing cutaneous conditions. Lasers Surg Med 50(8):859–882
pubmed: 29665018 doi: 10.1002/lsm.22823
Cuerda-Galindo E et al (2015) Increased fibroblast proliferation and activity after applying intense pulsed light 800–1200 nm. Ann Anat 198:66–72
pubmed: 25547460 doi: 10.1016/j.aanat.2014.11.005
Karu T (1999) Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol B 49(1):1–17
pubmed: 10365442 doi: 10.1016/S1011-1344(98)00219-X
Mejía LF, Gil JC, Jaramillo M (2019) Intense pulsed light therapy: a promising complementary treatment for dry eye disease. Arch Soc Esp Oftalmol (Engl Ed) 94(7):331–336
pubmed: 31079987 doi: 10.1016/j.oftal.2019.03.009
Arita R, Fukuoka S, Morishige N (2019) Therapeutic efficacy of intense pulsed light in patients with refractory meibomian gland dysfunction. Ocul Surf 17(1):104–110
pubmed: 30445177 doi: 10.1016/j.jtos.2018.11.004
Rong B et al (2018) Intense pulsed light Applied directly on eyelids combined with Meibomian Gland expression to treat Meibomian Gland Dysfunction. Photomed Laser Surg 36(6):326–332
pubmed: 29688838 doi: 10.1089/pho.2017.4402
Toyos R et al (2019) Evaluation of the safety and efficacy of intense pulsed light treatment with Meibomian Gland expression of the Upper eyelids for Dry Eye Disease. Photobiomodul Photomed Laser Surg 37(9):527–531
pubmed: 31335299
Xue AL et al (2020) Randomised double-masked placebo-controlled trial of the cumulative treatment efficacy profile of intense pulsed light therapy for meibomian gland dysfunction. Ocul Surf 18(2):286–297
pubmed: 32007523 doi: 10.1016/j.jtos.2020.01.003
Nelson JD et al (2017) TFOS DEWS II introduction. Ocul Surf 15(3):269–275
pubmed: 28736334 doi: 10.1016/j.jtos.2017.05.005
Uchino M et al (2014) Dry eye disease and work productivity loss in visual display users: the Osaka study. Am J Ophthalmol 157(2):294–300
pubmed: 24184225 doi: 10.1016/j.ajo.2013.10.014
Baudouin C et al (2016) Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction. Br J Ophthalmol 100(3):300–306
pubmed: 26781133 doi: 10.1136/bjophthalmol-2015-307415
Piyacomn Y (2020) Efficacy and safety of intense pulsed light in patients with Meibomian Gland Dysfunction-A Randomized, Double-Masked. Clinical Trial. Cornea
Gao YF et al (2019) Comparison of anti-inflammatory effects of intense pulsed light with tobramycin/dexamethasone plus warm compress on dry eye associated meibomian gland dysfunction. Int J Ophthalmol 12(11):1708–1713
pubmed: 31741858 pmcid: 6848864 doi: 10.18240/ijo.2019.11.07
Yurttaser Ocak S et al (2020) Intense pulse light therapy treatment for refractory dry eye disease due to meibomian gland dysfunction. Int Ophthalmol 40(5):1135–1141
pubmed: 31916061 doi: 10.1007/s10792-019-01278-3
Korb DR, Blackie CA (2011) Meibomian gland therapeutic expression: quantifying the applied pressure and the limitation of resulting pain. Eye Contact Lens 37(5):298–301
pubmed: 21617536 doi: 10.1097/ICL.0b013e31821bc7c5
Yan S, Wu Y (2021) Efficacy and safety of intense pulsed light therapy for dry eye caused by meibomian gland dysfunction: a randomised trial. Ann Palliat Med 10(7):7857–7865
pubmed: 34353073 doi: 10.21037/apm-21-1303
Rong B et al (2018) Long-Term effects of intense pulsed light combined with Meibomian Gland expression in the treatment of Meibomian Gland Dysfunction. Photomed Laser Surg 36(10):562–567
pubmed: 30251914 doi: 10.1089/pho.2018.4499
Shin KY et al (2021) Intense pulsed light plus meibomian gland expression versus intense pulsed light alone for meibomian gland dysfunction: a randomized crossover study. PLoS ONE 16(3):e0246245
pubmed: 33662017 pmcid: 7932142 doi: 10.1371/journal.pone.0246245
Kim WS, Calderhead RG (2011) Is light-emitting diode phototherapy (LED-LLLT) really effective? Laser Ther 20(3):205–215
pubmed: 24155530 pmcid: 3799034 doi: 10.5978/islsm.20.205
Mahe YF et al (2021) Low-level light therapy downregulates scalp inflammatory biomarkers in men with Androgenetic Alopecia and boosts Minoxidil 2% to bring a sustainable hair regrowth activity. Lasers Surg Med 53(9):1208–1219
pubmed: 33973663 pmcid: 9292036 doi: 10.1002/lsm.23398
Solomos L et al (2021) Meibomian gland dysfunction: intense pulsed light therapy in combination with low-level light therapy as Rescue Treatment. Medicina, 57(6)
Naudin T et al (2021) [Combined intense pulsed light and low-level light therapy in the treatment of meibomian gland dysfunction]. J Fr Ophtalmol 44(7):1021–1028
pubmed: 34172298 doi: 10.1016/j.jfo.2020.09.037
Stonecipher K et al (2019) Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction. Clin Ophthalmol 13:993–999
pubmed: 31354233 pmcid: 6573774 doi: 10.2147/OPTH.S213664
Pérez-Silguero MA et al (2021) Combined intense pulsed light and low-level light therapy for the treatment of Dry Eye: a Retrospective before-after study with one-year Follow-Up. Clin Ophthalmol 15:2133–2140
pubmed: 34045848 pmcid: 8149274 doi: 10.2147/OPTH.S307020
Gedar Totuk Ö (2021) Efficacy of intense pulsed light treatment for moderate to severe Acute blepharitis or blepharoconjunctivitis: a retrospective Case Series. Turk J Ophthalmol 51(2):89–94
pubmed: 33951896 pmcid: 8109034 doi: 10.4274/tjo.galenos.2020.28924
Ruan F et al (2019) Intense pulsed light therapy with optimal Pulse Technology as an Adjunct Therapy for moderate to severe blepharitis-Associated Keratoconjunctivitis. J Ophthalmol 2019:3143469
pubmed: 31637051 pmcid: 6766164 doi: 10.1155/2019/3143469
D’Souza S et al (2020) Algorithmic approach to diagnosis and management of post-refractive surgery dry eye disease. Indian J Ophthalmol 68(12):2888–2894
pubmed: 33229664 pmcid: 7856989 doi: 10.4103/ijo.IJO_1957_20
Toda I (2018) Dry Eye after LASIK. Invest Ophthalmol Vis Sci, 59(14): p. Des109-des115.
Nettune GR, Pflugfelder SC (2010) Post-LASIK tear dysfunction and dysesthesia. Ocul Surf 8(3):135–145
pubmed: 20712970 pmcid: 3579556 doi: 10.1016/S1542-0124(12)70224-0
Pazo EE et al (2021) Intense pulse light for treating Post-LASIK refractory Dry Eye. Photobiomodul Photomed Laser Surg 39(3):155–163
pubmed: 33296261
Wu Y et al (2022) Management of Post-LASIK Dry Eye with intense pulsed light in combination with 0.1% Sodium Hyaluronate and Heated Eye Mask. Ophthalmol Ther 11(1):161–176
pubmed: 34741758 doi: 10.1007/s40123-021-00418-2
Huo Y et al (2022) Therapeutic Effect of Intense Pulsed Light in Patients with Sjögren’s Syndrome Related Dry Eye. J Clin Med, 11(5)
Di Marino M et al (2021) Combined low-level light therapy and intense pulsed light therapy for the treatment of Dry Eye in patients with Sjögren’s syndrome. J Ophthalmol 2021:2023246
pubmed: 34221491 pmcid: 8213457 doi: 10.1155/2021/2023246
Wu Y et al (2022) Efficacy of intense pulsed light combined blood Extract Eye drops for treatment of Nociceptive Pain in Dry Eye patients. J Clin Med, 11(5)
Nelson JD et al (2011) The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee Invest Ophthalmol Vis Sci, 52(4): pp. 1930-7
Fukuoka S et al (2017) Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion. Clin Ophthalmol 11:1031–1038
pubmed: 28615923 pmcid: 5460643 doi: 10.2147/OPTH.S133060
Zhu Y et al (2022) Efficacy of intense pulsed light in the treatment of recurrent chalaziosis. Front Med (Lausanne) 9:839908
pubmed: 35299836 doi: 10.3389/fmed.2022.839908
Arita R, Fukuoka S (2022) Therapeutic Efficacy and Safety of Intense Pulsed Light for Refractive Multiple Recurrent Chalazia J Clin Med, 11(18)
Zhu Y et al (2023) Novel treatment of chalazion using light-guided-tip intense pulsed light. Sci Rep 13(1):12393
pubmed: 37524772 pmcid: 10390460 doi: 10.1038/s41598-023-39332-x

Auteurs

Ruida Chen (R)

Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, 1 Xihu avenue, Hangzhou, Zhejiang, 310009, China.
Eye Department, Affiliated Dongyang Hospital, Wenzhou Medical University, Dongyang, China.

Jiale Lu (J)

Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, 1 Xihu avenue, Hangzhou, Zhejiang, 310009, China.

Jilian Dong (J)

School of Public Health, Nanjing Medical University, Nanjing, China.

Yirui Zhu (Y)

Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, 1 Xihu avenue, Hangzhou, Zhejiang, 310009, China. yiruizhu@zju.edu.cn.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH