Predictors of mortality and rehabilitation location in adults with prolonged coma following traumatic brain injury.


Journal

PM & R : the journal of injury, function, and rehabilitation
ISSN: 1934-1563
Titre abrégé: PM R
Pays: United States
ID NLM: 101491319

Informations de publication

Date de publication:
24 Apr 2024
Historique:
revised: 15 02 2024
received: 15 06 2023
accepted: 25 02 2024
medline: 24 4 2024
pubmed: 24 4 2024
entrez: 24 4 2024
Statut: aheadofprint

Résumé

Traumatic brain injury (TBI) is a leading cause of death and disability, often resulting in prolonged coma and disordered consciousness. There are currently gaps in understanding the factors affecting rehabilitation location and outcome after TBI. To identify the impact of demographics, comorbidities, and complications on discharge disposition in adults with prolonged coma following TBI. Retrospective cohort study. Tertiary care hospitals and trauma centers in the United States. Patients 18 years of age or older with TBI and prolonged coma during the years 2008 to 2015. Not applicable. Demographics, clinical injury data, comorbidities, and complications were collected, and odds ratios (ORs) and descriptive analysis were calculated for mortality, long-term rehabilitation, and home discharge without services. A total of 6929 patients with TBI and prolonged coma were included in the final analysis; 3318 (47.9%) were discharged to rehabilitation facilities, 1859 (26.8%) died, and 1752 (25.3%) were discharged home. Older patients and those with higher injury severity scores had significantly higher ORs for mortality and rehab discharge. A total of 58.3% of patients presented with at least one comorbidity. Non-White ethnicities and self-pay/uninsured patients were significantly less likely to be discharged to a rehab facility. Furthermore, comorbidities including congestive heart failure (CHF) and diabetes were associated with a significantly increased OR for mortality and rehab discharge compared to home discharge without services. Comorbidities, age, and injury severity were the most significant risk factors for increased mortality and acute rehab discharge. Maximizing the treatment of comorbidities including CHF and diabetes has the potential to decrease mortality and adverse outcomes following TBI with prolonged coma.

Identifiants

pubmed: 38656699
doi: 10.1002/pmrj.13177
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 American Academy of Physical Medicine and Rehabilitation.

Références

Frieden TR, Houry D, Baldwin G. Traumatic brain injury in the United States: epidemiology and rehabilitation. CDC NIH Rep to Congr. 2015;1‐74.
Provencio JJ, Hemphill JC, Claassen J, et al. The curing coma campaign: framing initial scientific challenges—proceedings of the first curing coma campaign scientific advisory council meeting. Neurocrit Care. 2020;33(1):1‐12. doi:10.1007/s12028‐020‐01028‐9
Firsching R. Coma after acute head injury. Dtsch Arztebl Int. 2017;114:313‐320. doi:10.3238/arztebl.2017.0313
Lippert‐Grüner M, Wedekind C, Klug N. Outcome of prolonged coma following severe traumatic brain injury. Brain Inj. 2003;17(1):49‐54. doi:10.1080/0269905021000010230
Grossman P, Hagel K. Post‐traumatic apallic syndrome following head injury. Part 1: clinical characteristics. Disabil Rehabil. 1996;18(1):1‐20. doi:10.3109/09638289609167084
Talbot LR, Whitaker HA. Brain‐injured persons in an altered state of consciousness: measures and intervention strategies. Brain Inj. 1994;8(8):689‐699. doi:10.3109/02699059409151023
Cuthbert JP, Corrigan JD, Harrison‐Felix C, et al. Factors that predict acute hospitalization discharge disposition for adults with moderate to severe traumatic brain injury. Arch Phys Med Rehabil. 2011;92(5):721‐730. doi:10.1016/j.apmr.2010.12.023
Lu J, Gormley M, Donaldson A, Agyemang A, Karmarkar A, Seel RT. Identifying factors associated with acute hospital discharge dispositions in patients with moderate‐to‐severe traumatic brain injury. Brain Inj. 2022;36(3):383‐392. doi:10.1080/02699052.2022.2034180
Schumacher R, Walder B, Delhumeau C, Müri RM. Predictors of inpatient (neuro)rehabilitation after acute care of severe traumatic brain injury: an epidemiological study. Brain Inj. 2016;30(10):1186‐1193. doi:10.1080/02699052.2016.1183821
Chan L, Doctor J, Temkin N, et al. Discharge disposition from acute care after traumatic brain injury: the effect of insurance type. Arch Phys Med Rehabil. 2001;82(9):1151‐1154. doi:10.1053/apmr.2001.24892
Turner‐Stokes L, Pick A, Nair A, Disler PB, Wade DT. Multi‐disciplinary rehabilitation for acquired brain injury in adults of working age. Cochrane Database Syst Rev. 2015;2015(12):Cd004170. doi:10.1002/14651858.CD004170.pub3
Cicerone KD, Langenbahn DM, Braden C, et al. Evidence‐based cognitive rehabilitation: updated review of the literature from 2003 through 2008. Arch Phys Med Rehabil. 2011;92(4):519‐530. doi:10.1016/j.apmr.2010.11.015
Malec JF, Mandrekar JN, Brown AW, Moessner AM. Injury severity and disability in the selection of next level of care following acute medical treatment for traumatic brain injury. Brain Inj. 2009;23(1):22‐29. doi:10.1080/02699050802590320
Leblanc J, Guise ED, Gosselin N, Feyz M. Comparison of functional outcome following acute care in young, middle‐aged and elderly patients with traumatic brain injury. Brain Inj. 2006;20(8):779‐790. doi:10.1080/02699050600831835
Coronado VG, Thomas KE, Sattin RW, Johnson RL. The CDC traumatic brain injury surveillance system: characteristics of persons aged 65 years and older hospitalized with a TBI. J Head Trauma Rehabil. 2005;20(3):215‐228. doi:10.1097/00001199‐200505000‐00005
Zarshenas S, Colantonio A, Alavinia SM, Jaglal S, Tam L, Cullen N. Predictors of discharge destination from acute care in patients with traumatic brain injury: a systematic review. J Head Trauma Rehabil. 2019;34(1):52‐64. doi:10.1097/htr.0000000000000403
Arango‐Lasprilla JC, Kreutzer JS. Racial and ethnic disparities in functional, psychosocial, and neurobehavioral outcomes after brain injury. J Head Trauma Rehabil. 2010;25(2):128‐136. doi:10.1097/HTR.0b013e3181d36ca3
Gary KW, Arango‐Lasprilla JC, Stevens LF. Do racial/ethnic differences exist in post‐injury outcomes after TBI? A comprehensive review of the literature. Brain Inj. 2009;23(10):775‐789. doi:10.1080/02699050903200563
Mellick D, Gerhart KA, Whiteneck GG. Understanding outcomes based on the post‐acute hospitalization pathways followed by persons with traumatic brain injury. Brain Inj. 2003;17(1):55‐71. doi:10.1080/0269905021000010159
Areas FZ, Schwarzbold ML, Diaz AP, et al. Predictors of hospital mortality and the related burden of disease in severe traumatic brain injury: a prospective multicentric study in Brazil. Front Neurol. 2019;10:432.
Okidi R, Ogwang DM, Okello TR, et al. Factors affecting mortality after traumatic brain injury in a resource‐poor setting. BJS Open. 2020;4(2):320‐325.
Verchère J, Blanot S, Vergnaud E, Vecchione A, Zerah M, Meyer PG. Mortality in severe traumatic brain injury. Lancet Neurol. 2013;12(5):426‐427. doi:10.1016/s1474‐4422(13)70073‐5
Martins ET, Linhares MN, Sousa DS, et al. Mortality in severe traumatic brain injury: a multivariated analysis of 748 Brazilian patients from Florianópolis City. J Trauma. 2009;1:85‐90.
De Koning ME, Spikman JM, Coers A, Schönherr MC, Van Der Naalt J. Pathways of care the first year after moderate and severe traumatic brain injury—discharge destinations and outpatient follow‐up. Brain Inj. 2015;29(4):423‐429. doi:10.3109/02699052.2014.982188
Jourdan C, Bayen E, Bosserelle V, et al. Referral to rehabilitation after severe traumatic brain injury: results from the PariS‐TBI study. Neurorehabil Neural Repair. 2013;1:35‐44.
Carlsson CA, von Essen C, Löfgren J. Factors affecting the clinical corse of patients with severe head injuries. 1. Influence of biological factors. 2. Significance of posttraumatic coma. J Neurosurg. 1968;29(3):242‐251. doi:10.3171/jns.1968.29.3.0242
Hukkelhoven CW, Steyerberg EW, Rampen AJ, et al. Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients. J Neurosurg. 2003;99(4):666‐673. doi:10.3171/jns.2003.99.4.0666
Chan V, Mollayeva T, Ottenbacher KJ, Colantonio A. Clinical profile and comorbidity of traumatic brain injury among younger and older men and women: a brief research notes. BMC Res Notes. 2017;10(1):371. doi:10.1186/s13104‐017‐2682‐x
van Baalen B, Odding E, Stam HJ. Cognitive status at discharge from the hospital determines discharge destination in traumatic brain injury patients. Brain Inj. 2008;1:25‐32.
Tepas JJ 3rd, Pracht EE, Orban BL, Flint LM. High‐volume trauma centers have better outcomes treating traumatic brain injury. J Trauma Acute Care Surg. 2013;1:143‐147.
Asemota AO, George BP, Cumpsty‐Fowler CJ, Haider AH, Schneider EB. Race and insurance disparities in discharge to rehabilitation for patients with traumatic brain injury. J Neurotrauma. 2013;30(24):2057‐2065.
Zogg CK, Scott JW, Metcalfe D, et al. The association between medicare eligibility and gains in access to rehabilitative care: a national regression discontinuity assessment of patients ages 64 versus 65 years. Ann Surg. 2017;4:734‐742.
McQuistion K, Zens T, Jung HS, et al. Insurance status and race affect treatment and outcome of traumatic brain injury. J Surg Res. 2016;2:261‐271.
Kane WG, Wright DA, Fu R, Carlson KF. Racial/ethnic and insurance status disparities in discharge to posthospitalization care for patients with traumatic brain injury. J Head Trauma Rehabil. 2014;29(6):E10‐E17. doi:10.1097/htr.0000000000000028
Meagher AD, Beadles CA, Doorey J, Charles AG. Racial and ethnic disparities in discharge to rehabilitation following traumatic brain injury. J Neurosurg. 2015;122(3):595‐601. doi:10.3171/2014.10.jns14187
Wijayatilake DS, Sherren PB, Jigajinni SV. Systemic complications of traumatic brain injury. Curr Opin Anaesthesiol. 2015;28(5):525‐531. doi:10.1097/aco.0000000000000236
Faugeras F, Rohaut B, Valente M, et al. Survival and consciousness recovery are better in the minimally conscious state than in the vegetative state. Brain Inj. 2018;32(1):72‐77. doi:10.1080/02699052.2017.1364421
Holbrook TL, Hoyt DB, Anderson JP. The impact of major in‐hospital complications on functional outcome and quality of life after trauma. J Trauma Acute Care Surg. 2001;50(1):91‐95.
Lee JM, Herrera‐Escobar J, Apoj M, et al. The impact of in‐hospital complications on the long‐term functional outcome of trauma patients: a multicenter study. Surgery. 2019;3:398‐402.

Auteurs

Joshua Cassinat (J)

University of Central Florida College of Medicine, Orlando, Florida, USA.

Joseph Nygaard (J)

University of Central Florida College of Medicine, Orlando, Florida, USA.

Collin Hoggard (C)

University of Central Florida College of Medicine, Orlando, Florida, USA.

Michael Hoffmann (M)

University of Central Florida College of Medicine, Orlando, Florida, USA.
Neurology Section, Orlando VA Medical Center, Orlando, Florida, USA.

Classifications MeSH