Seco-cyclic phorbol derivatives and their anti-HIV-1 activities.

HIV-1 / drug effects Humans Anti-HIV Agents / pharmacology Phorbol Esters / pharmacology Molecular Structure Protein Kinase C / metabolism Structure-Activity Relationship
Anti-HIV-1 agent Cyclopropane ring Esterification Hydrolysis reaction seco-Cyclic phorbol derivatives

Journal

Chinese journal of natural medicines
ISSN: 1875-5364
Titre abrégé: Chin J Nat Med
Pays: China
ID NLM: 101504416

Informations de publication

Date de publication:
Apr 2024
Historique:
received: 13 10 2023
medline: 25 4 2024
pubmed: 25 4 2024
entrez: 24 4 2024
Statut: ppublish

Résumé

Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C (PKC). The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20, C3/C4, and C9 of phorbol. Concurrently, the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-ligand complex. The influence of the cyclopropane ring at positions C13 and C14 in phorbol derivatives on their anti-HIV-1 activity requires further exploration. This research entailed the hydrolysis of phorbol, producing seco-cyclic phorbol derivatives. The anti-HIV-1 efficacy of these derivatives was assessed, and the affinity constant (K

Identifiants

DOI: 10.1016/S1875-5364(24)60630-8 PMID: 38658099
pubmed: 38658099
pii: S1875-5364(24)60630-8
doi: 10.1016/S1875-5364(24)60630-8
pii:
doi:

Substances chimiques

Anti-HIV Agents 0
Phorbol Esters 0
Protein Kinase C EC 2.7.11.13

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

365-374

Informations de copyright

Copyright © 2024 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Auteurs

Xiaolei Huang (X)

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.

Xusheng Huang (X)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China.

Qirun Li (Q)

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.

Mengdi Ma (M)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

Yadong Cui (Y)

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.

Liumeng Yang (L)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

Haibo Wang (H)

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.

Ronghua Luo (R)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

Jinglei Chen (J)

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.

Jingxuan Yang (J)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China.

Jinrong Lin (J)

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.

Duxin Li (D)

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. Electronic address: duxin.li@suda.edu.cn.

Yongtang Zheng (Y)

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China. Electronic address: zhengyt@mail.kiz.ac.cn.

Jian Zhang (J)

College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. Electronic address: jianzhang@suda.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Seco-cyclic phorbol derivatives and their...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Seco-cyclic phorbol derivatives and their...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Agents antiVIH › Seco-cyclic phorbol derivatives and their...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Phorbols › Esters de phorbol › Seco-cyclic phorbol derivatives and their...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Seco-cyclic phorbol derivatives and their...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Protéine kinase C › Seco-cyclic phorbol derivatives and their...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Seco-cyclic phorbol derivatives and their...