Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program.


Journal

NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891

Informations de publication

Date de publication:
24 Apr 2024
Historique:
received: 27 09 2023
accepted: 05 04 2024
medline: 25 4 2024
pubmed: 25 4 2024
entrez: 24 4 2024
Statut: epublish

Résumé

Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8 liquids per patient from its first 20 patients. In a dedicated experiment, we show the mild impact of increasing time after death on RNA quality, transcriptional profiles and immunohistochemical staining in tumor tissue samples. We show that this impact can be counteracted by organ cooling. We successfully generated ex vivo models from tissue and liquid biopsies from distinct histological subtypes of breast cancer. We anticipate these and future findings of UPTIDER to elucidate mechanisms of disease progression and treatment resistance and to provide tools for the exploration of precision medicine strategies in the metastatic setting.

Identifiants

pubmed: 38658604
doi: 10.1038/s41523-024-00637-3
pii: 10.1038/s41523-024-00637-3
doi:

Types de publication

Journal Article

Langues

eng

Pagination

31

Subventions

Organisme : KU Leuven (Katholieke Universiteit Leuven)
ID : C14/21/114
Organisme : KU Leuven (Katholieke Universiteit Leuven)
ID : C14/18/092 and C14/22/125
Organisme : European Cooperation in Science and Technology (COST)
ID : LOBSTERPOT CA19138
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : 1S76522N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : G0B6120N, G093821N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : 1802222N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : 1297322N
Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : ITN-2019-859860-CANCERPREV

Informations de copyright

© 2024. The Author(s).

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Auteurs

Tatjana Geukens (T)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

Maxim De Schepper (M)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Department of Pathology, University Hospitals Leuven, Leuven, Belgium.

Wouter Van Den Bogaert (W)

Department of Forensic Medicine, University Hospitals Leuven, Leuven, Belgium.

Karen Van Baelen (K)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.

Marion Maetens (M)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.

Anirudh Pabba (A)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.

Amena Mahdami (A)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.

Sophia Leduc (S)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.

Edoardo Isnaldi (E)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.

Ha-Linh Nguyen (HL)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.

Imane Bachir (I)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Department of Anesthesiology, Institut Jules Bordet, Brussels, Belgium.

Maysam Hajipirloo (M)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.

Gitte Zels (G)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Department of Pathology, University Hospitals Leuven, Leuven, Belgium.

Josephine Van Cauwenberge (J)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.

Kristien Borremans (K)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.

Vincent Vandecaveye (V)

Department of Radiology, University Hospitals Leuven, Leuven, Belgium.

Birgit Weynand (B)

Department of Pathology, University Hospitals Leuven, Leuven, Belgium.

Peter Vermeulen (P)

Centre for Oncological Research (CORE), University of Antwerp, Antwerp, Belgium.

Eleonora Leucci (E)

TRACE and Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.

Maria Francesca Baietti (MF)

TRACE and Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.

George Sflomos (G)

ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Laura Battista (L)

ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Cathrin Brisken (C)

ISREC - Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
The Breast Cancer Now Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.

Patrick W B Derksen (PWB)

Department of Pathology, University Medical Center, Utrecht, The Netherlands.

Thijs Koorman (T)

Department of Pathology, University Medical Center, Utrecht, The Netherlands.

Daan Visser (D)

Department of Pathology, University Medical Center, Utrecht, The Netherlands.

Colinda L G J Scheele (CLGJ)

Laboratory of Intravital Microscopy and Dynamics of Tumor Progression, Department of Oncology, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium.

Daniela S Thommen (DS)

Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Sigrid Hatse (S)

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.

Sarah-Maria Fendt (SM)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Evy Vanderheyden (E)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, and VIB Center for Cancer Biology, Leuven, Belgium.

Thomas Van Brussel (T)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, and VIB Center for Cancer Biology, Leuven, Belgium.

Rogier Schepers (R)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, and VIB Center for Cancer Biology, Leuven, Belgium.

Bram Boeckx (B)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, and VIB Center for Cancer Biology, Leuven, Belgium.

Diether Lambrechts (D)

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, and VIB Center for Cancer Biology, Leuven, Belgium.

Giuseppe Marano (G)

Unit of Medical Statistics, Biometry and Epidemiology, Department of Biomedical and Clinical Sciences (DIBIC) "L. Sacco" & DSRC, LITA Vialba campus, Università degli Studi di Milano, Milan, Italy.

Elia Biganzoli (E)

Unit of Medical Statistics, Biometry and Epidemiology, Department of Biomedical and Clinical Sciences (DIBIC) "L. Sacco" & DSRC, LITA Vialba campus, Università degli Studi di Milano, Milan, Italy.

Ann Smeets (A)

Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium.

Ines Nevelsteen (I)

Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium.

Kevin Punie (K)

Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

Patrick Neven (P)

Department of Gynecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.

Hans Wildiers (H)

Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

François Richard (F)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.

Giuseppe Floris (G)

Department of Pathology, University Hospitals Leuven, Leuven, Belgium.

Christine Desmedt (C)

Laboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium. christine.desmedt@kuleuven.be.

Classifications MeSH