PGE


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
24 Apr 2024
Historique:
received: 22 05 2023
accepted: 28 02 2024
medline: 25 4 2024
pubmed: 25 4 2024
entrez: 24 4 2024
Statut: aheadofprint

Résumé

Cancer-specific TCF1

Identifiants

pubmed: 38658748
doi: 10.1038/s41586-024-07254-x
pii: 10.1038/s41586-024-07254-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

Jansen, C. S. et al. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells. Nature 576, 465–470 (2019).
pubmed: 31827286 pmcid: 7108171 doi: 10.1038/s41586-019-1836-5
Siddiqui, I. et al. Intratumoral Tcf1
pubmed: 30635237 doi: 10.1016/j.immuni.2018.12.021
Prokhnevska, N. et al. CD8
pubmed: 36580918 doi: 10.1016/j.immuni.2022.12.002
Zehn, D., Thimme, R., Lugli, E., de Almeida, G. P. & Oxenius, A. ‘Stem-like’ precursors are the fount to sustain persistent CD8
pubmed: 35624209 doi: 10.1038/s41590-022-01219-w
Miller, B. C. et al. Subsets of exhausted CD8
pubmed: 30778252 pmcid: 6673650 doi: 10.1038/s41590-019-0312-6
Codarri Deak, L. et al. PD-1-cis IL-2R agonism yields better effectors from stem-like CD8
pubmed: 36171284 pmcid: 9534752 doi: 10.1038/s41586-022-05192-0
Krishna, S. et al. Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer. Science 370, 1328–1334 (2020).
pubmed: 33303615 pmcid: 8883579 doi: 10.1126/science.abb9847
Liu, B. et al. Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Nat. Cancer 3, 108–121 (2022).
pubmed: 35121991 doi: 10.1038/s43018-021-00292-8
Kurtulus, S. et al. Checkpoint blockade immunotherapy induces dynamic changes in PD-1–CD8
pubmed: 30635236 pmcid: 6336113 doi: 10.1016/j.immuni.2018.11.014
Gatto, F., Schulze, A. & Nielsen, J. Systematic analysis reveals that cancer mutations converge on deregulated metabolism of arachidonate and xenobiotics. Cell Rep. 16, 878–895 (2016).
pubmed: 27396332 doi: 10.1016/j.celrep.2016.06.038
Wang, D. & DuBois, R. N. Eicosanoids and cancer. Nat. Rev. Cancer 10, 181–193 (2010).
pubmed: 20168319 pmcid: 2898136 doi: 10.1038/nrc2809
Wang, Q., Morris, R. J., Bode, A. M. & Zhang, T. Prostaglandin pathways: opportunities for cancer prevention and therapy. Cancer Res. 82, 949–965 (2022).
pubmed: 34949672 pmcid: 8930508 doi: 10.1158/0008-5472.CAN-21-2297
Finetti, F. et al. Prostaglandin E2 and cancer: insight into tumor progression and immunity. Biology 9, 434 (2020).
pubmed: 33271839 pmcid: 7760298 doi: 10.3390/biology9120434
Zelenay, S. et al. Cyclooxygenase-dependent tumor growth through evasion of immunity. Cell 162, 1257–1270 (2015).
pubmed: 26343581 pmcid: 4597191 doi: 10.1016/j.cell.2015.08.015
Böttcher, J. P. et al. NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control. Cell 172, 1022–1037.e14 (2018).
pubmed: 29429633 pmcid: 5847168 doi: 10.1016/j.cell.2018.01.004
Kalinski, P. Regulation of immune responses by prostaglandin E2. J. Immunol. 188, 21–28 (2012).
pubmed: 22187483 doi: 10.4049/jimmunol.1101029
Chen, J. H. et al. Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. Nat. Med. 21, 327–334 (2015).
pubmed: 25799228 pmcid: 4505619 doi: 10.1038/nm.3831
Mosenden, R. et al. Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency. J. Immunol. 186, 5119–5130 (2011).
pubmed: 21430226 doi: 10.4049/jimmunol.1100003
Newick, K. et al. Augmentation of CAR T-cell trafficking and antitumor efficacy by blocking protein kinase A localization. Cancer Immunol. Res. 4, 541–551 (2015).
doi: 10.1158/2326-6066.CIR-15-0263
Lone, A. M. & Taskén, K. Phosphoproteomics-based characterization of prostaglandin E2 signaling in T cells. Mol. Pharmacol. 99, 370–382 (2021).
pubmed: 33674363 doi: 10.1124/molpharm.120.000170
Roberts, E. W. et al. Critical role for CD103
pubmed: 27424807 pmcid: 5374862 doi: 10.1016/j.ccell.2016.06.003
Spranger, S., Bao, R. & Gajewski, T. F. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature 523, 231–235 (2015).
pubmed: 25970248 doi: 10.1038/nature14404
Böttcher, J. P. et al. Functional classification of memory CD8
pubmed: 26404698 doi: 10.1038/ncomms9306
Zander, R. et al. CD4
pubmed: 31810883 pmcid: 6929322 doi: 10.1016/j.immuni.2019.10.009
Aandahl, E. M. et al. CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets. J. Immunol. 170, 2349–2355 (2003).
pubmed: 12594257 doi: 10.4049/jimmunol.170.5.2349
Alfei, F. et al. TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. Nature 571, 265–269 (2019).
pubmed: 31207605 doi: 10.1038/s41586-019-1326-9
Scott, A. C. et al. TOX is a critical regulator of tumour-specific T cell differentiation. Nature 571, 270–274 (2019).
pubmed: 31207604 pmcid: 7698992 doi: 10.1038/s41586-019-1324-y
Tsui, C. et al. MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature 609, 354–360 (2022).
pubmed: 35978192 pmcid: 9452299 doi: 10.1038/s41586-022-05105-1
Yost, K. E. et al. Clonal replacement of tumor-specific T cells following PD-1 blockade. Nat. Med. 25, 1251–1259 (2019).
pubmed: 31359002 pmcid: 6689255 doi: 10.1038/s41591-019-0522-3
Lucca, L. E. et al. Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells. J. Exp. Med. 218, e20200921 (2021).
pubmed: 33651881 pmcid: 7933991 doi: 10.1084/jem.20200921
Mandala, S. et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296, 346–349 (2002).
pubmed: 11923495 doi: 10.1126/science.1070238
Ross, S. H. & Cantrell, D. A. Signaling and function of interleukin-2 in T lymphocytes. Annu. Rev. Immunol. 36, 411–433 (2018).
pubmed: 29677473 pmcid: 6472684 doi: 10.1146/annurev-immunol-042617-053352
Hashimoto, M. et al. PD-1 combination therapy with IL-2 modifies CD8
pubmed: 36171288 pmcid: 9793890 doi: 10.1038/s41586-022-05257-0
Corria-Osorio, J. et al. Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8
pubmed: 37081150 pmcid: 10154250 doi: 10.1038/s41590-023-01477-2
Di Pilato, M. et al. CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. Cell 184, 4512–4530.e22 (2021).
pubmed: 34343496 pmcid: 8719451 doi: 10.1016/j.cell.2021.07.015
Danilo, M., Chennupati, V., Silva, J. G., Siegert, S. & Held, W. Suppression of Tcf1 by inflammatory cytokines facilitates effector CD8 T cell differentiation. Cell Rep. 22, 2107–2117 (2018).
pubmed: 29466737 doi: 10.1016/j.celrep.2018.01.072
Morotti, M. et al. PGE
Bayerl, F. et al. Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses. Immunity 56, 1341–1358.e11 (2023).
pubmed: 37315536 doi: 10.1016/j.immuni.2023.05.011
Meiser, P. et al. A distinct stimulatory cDC1 subpopulation amplifies CD8
pubmed: 37451271 doi: 10.1016/j.ccell.2023.06.008
Mo, F. et al. An engineered IL-2 partial agonist promotes CD8
pubmed: 34526724 pmcid: 9172917 doi: 10.1038/s41586-021-03861-0
Tichet, M. et al. Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8
pubmed: 36630914 doi: 10.1016/j.immuni.2022.12.006
Leonard, W. J., Lin, J.-X. & O’Shea, J. J. The γc family of cytokines: basic biology to therapeutic ramifications. Immunity 50, 832–850 (2019).
pubmed: 30995502 doi: 10.1016/j.immuni.2019.03.028
Biringer, R. G. A review of prostanoid receptors: expression, characterization, regulation, and mechanism of action. J. Cell Commun. Signal. 15, 155–184 (2021).
pubmed: 32970276 doi: 10.1007/s12079-020-00585-0
Wübbenhorst, D. et al. Tetracycline-regulated bone morphogenetic protein 2 gene expression in lentivirally transduced primary rabbit chondrocytes for treatment of cartilage defects. Arthritis Rheum. 62, 2037–2046 (2010).
pubmed: 20309869 doi: 10.1002/art.27461
Di Pilato, M. et al. Targeting the CBM complex causes T
pubmed: 31092922 pmcid: 6656391 doi: 10.1038/s41586-019-1215-2
Oh, S. A., Seki, A. & Rutz, S. Ribonucleoprotein transfection for CRISPR/Cas9-mediated gene knockout in primary T cells. Curr. Protoc. Immunol. 124, e69 (2019).
pubmed: 30334617 doi: 10.1002/cpim.69
Labun, K. et al. CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing. Nucleic Acids Res. 47, W171–W174 (2019).
pubmed: 31106371 pmcid: 6602426 doi: 10.1093/nar/gkz365
Doench, J. G. et al. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR–Cas9. Nat. Biotechnol. 34, 184–191 (2016).
pubmed: 26780180 pmcid: 4744125 doi: 10.1038/nbt.3437
Zheng, G. X. Y. et al. Massively parallel digital transcriptional profiling of single cells. Nat. Commun. 8, 14049 (2017).
pubmed: 28091601 pmcid: 5241818 doi: 10.1038/ncomms14049
Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573–3587.e29 (2021).
pubmed: 34062119 pmcid: 8238499 doi: 10.1016/j.cell.2021.04.048
Hafemeister, C. & Satija, R. Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol. 20, 296 (2019).
pubmed: 31870423 pmcid: 6927181 doi: 10.1186/s13059-019-1874-1
Ahlmann-Eltze, C. & Huber, W. glmGamPoi: fitting Gamma–Poisson generalized linear models on single cell count data. Bioinformatics 36, 5701–5702 (2021).
pubmed: 33295604 doi: 10.1093/bioinformatics/btaa1009
Aran, D. et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat. Immunol. 20, 163–172 (2019).
pubmed: 30643263 pmcid: 6340744 doi: 10.1038/s41590-018-0276-y
Gattinoni, L. et al. A human memory T cell subset with stem cell-like properties. Nat. Med. 17, 1290–1297 (2011).
pubmed: 21926977 pmcid: 3192229 doi: 10.1038/nm.2446
Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).
pubmed: 25516281 pmcid: 4302049 doi: 10.1186/s13059-014-0550-8
Kaech, S. M., Hemby, S., Kersh, E. & Ahmed, R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111, 837–851 (2002).
pubmed: 12526810 doi: 10.1016/S0092-8674(02)01139-X
Street, K. et al. Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics. BMC Genomics 19, 477 (2018).
pubmed: 29914354 pmcid: 6007078 doi: 10.1186/s12864-018-4772-0
Borcherding, N., Bormann, N. L. & Kraus, G. scRepertoire: an R-based toolkit for single-cell immune receptor analysis. F1000Research 9, 47 (2020).
pubmed: 32789006 pmcid: 7400693 doi: 10.12688/f1000research.22139.1
Badia-I-Mompel, P. et al. decoupleR: ensemble of computational methods to infer biological activities from omics data. Bioinform. Adv. 2, vbac016 (2022).
pubmed: 36699385 pmcid: 9710656 doi: 10.1093/bioadv/vbac016
Holland, C. H., Szalai, B. & Saez-Rodriguez, J. Transfer of regulatory knowledge from human to mouse for functional genomics analysis. Biochim. Biophys. Acta Gene Regul. Mech. 1863, 194431 (2020).
pubmed: 31525460 doi: 10.1016/j.bbagrm.2019.194431
Pedersen, T. tidygraph: A tidy API for graph manipulation. GitHub https://github.com/thomasp85/tidygraph (2023).
Csárdi, G. and Nepusz, T. The igraph software package for complex network research. Gigascience https://doi.org/10.1093/gigascience/giab008 (2006).
Ramírez, F. et al. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 44, W160–W165 (2016).
pubmed: 27079975 pmcid: 4987876 doi: 10.1093/nar/gkw257
Danecek, P. et al. Twelve years of SAMtools and BCFtools. GigaScience 10, giab008 (2021).
pubmed: 33590861 pmcid: 7931819 doi: 10.1093/gigascience/giab008
Ou, J. & Zhu, L. J. trackViewer: a Bioconductor package for interactive and integrative visualization of multi-omics data. Nat. Methods 16, 453–454 (2019).
pubmed: 31133757 doi: 10.1038/s41592-019-0430-y

Auteurs

Sebastian B Lacher (SB)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Janina Dörr (J)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.

Gustavo P de Almeida (GP)

Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, TUM, Freising, Germany.

Julian Hönninger (J)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, TUM, Munich, Germany.

Felix Bayerl (F)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Anna Hirschberger (A)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Anna-Marie Pedde (AM)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Philippa Meiser (P)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Lukas Ramsauer (L)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Thomas J Rudolph (TJ)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Nadine Spranger (N)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Matteo Morotti (M)

Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.
Department of Oncology, University Hospital of Lausanne (CHUV) and UNIL, Lausanne, Switzerland.
Agora Cancer Research Center, Lausanne, Switzerland.

Alizee J Grimm (AJ)

Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.
Department of Oncology, University Hospital of Lausanne (CHUV) and UNIL, Lausanne, Switzerland.
Agora Cancer Research Center, Lausanne, Switzerland.

Sebastian Jarosch (S)

Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, TUM, Munich, Germany.
Boehringer Ingelheim, Biberach, Germany.

Arman Oner (A)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.

Lisa Gregor (L)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.

Stefanie Lesch (S)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.

Stefanos Michaelides (S)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.

Luisa Fertig (L)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.

Daria Briukhovetska (D)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.

Lina Majed (L)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.

Sophia Stock (S)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.
Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.
German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany.

Dirk H Busch (DH)

Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, TUM, Munich, Germany.

Veit R Buchholz (VR)

Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine and Health, TUM, Munich, Germany.

Percy A Knolle (PA)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.

Dietmar Zehn (D)

Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, TUM, Freising, Germany.

Denarda Dangaj Laniti (D)

Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.
Department of Oncology, University Hospital of Lausanne (CHUV) and UNIL, Lausanne, Switzerland.
Agora Cancer Research Center, Lausanne, Switzerland.

Sebastian Kobold (S)

Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, Member of the German Center for Lung Research (DZL), LMU Munich, Munich, Germany.
German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and LMU University Hospital, Munich, Germany.
Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Munich, Research Center for Environmental Health (HMGU), Neuherberg, Germany.

Jan P Böttcher (JP)

Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany. j.boettcher@tum.de.

Classifications MeSH