Effects of a Global

adipocytes cardiomyopathies echocardiography lipids myography

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
25 Apr 2024
Historique:
medline: 25 4 2024
pubmed: 25 4 2024
entrez: 25 4 2024
Statut: aheadofprint

Résumé

RAB27A, a modulator of secretion, is expressed within vessels and perivascular adipose tissue. We hypothesized that loss of RAB27A would alter cardiovascular function. Body weight of Genome-wide association data linked rare human Global RAB27A loss impacted perivascular adipose tissue and thoracic aorta proteomic signatures, altered vasocontractile responses, and decreased left ventricular ejection fraction in mice.

Sections du résumé

BACKGROUND UNASSIGNED
RAB27A, a modulator of secretion, is expressed within vessels and perivascular adipose tissue. We hypothesized that loss of RAB27A would alter cardiovascular function.
METHODS UNASSIGNED
Body weight of
RESULTS UNASSIGNED
Genome-wide association data linked rare human
CONCLUSIONS UNASSIGNED
Global RAB27A loss impacted perivascular adipose tissue and thoracic aorta proteomic signatures, altered vasocontractile responses, and decreased left ventricular ejection fraction in mice.

Identifiants

DOI: 10.1161/ATVBAHA.124.320969 PMID: 38660803
pubmed: 38660803
doi: 10.1161/ATVBAHA.124.320969
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Ashley Soucy (A)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Graduate School of Biomedical Science and Engineering, University of Maine, Orono (A.S., M.M.G., R.K., I.P., C.V., L.L.).

Christian Potts (C)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
ORCID: 0009-0007-7794-7840

Abigail Kaija (A)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
ORCID: 0009-0003-0724-7751

Anne Harrington (A)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).

Marissa McGilvrey (M)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
ORCID: 0000-0003-1707-8886

George L Sutphin (GL)

The Jackson Laboratory, Bar Harbor, ME (G.L.S., R.K.).
Now with Department of Molecular and Cellular Biology, University of Arizona, Tucson (G.L.S.).
ORCID: 0000-0002-3659-4678

Ron Korstanje (R)

Graduate School of Biomedical Science and Engineering, University of Maine, Orono (A.S., M.M.G., R.K., I.P., C.V., L.L.).
The Jackson Laboratory, Bar Harbor, ME (G.L.S., R.K.).
ORCID: 0000-0002-2808-1610

Benjamin Tero (B)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).

Jacob Seeker (J)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
ORCID: 0009-0003-0622-6799

Ilka Pinz (I)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Graduate School of Biomedical Science and Engineering, University of Maine, Orono (A.S., M.M.G., R.K., I.P., C.V., L.L.).

Calvin Vary (C)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Graduate School of Biomedical Science and Engineering, University of Maine, Orono (A.S., M.M.G., R.K., I.P., C.V., L.L.).

Larisa Ryzhova (L)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).

Lucy Liaw (L)

MaineHealth Institute for Research, MaineHealth, Scarborough, ME (A.S., C.P., A.K., A.H., M.M., B.T., J.S., I.P., C.V., L.R., L.L.).
Graduate School of Biomedical Science and Engineering, University of Maine, Orono (A.S., M.M.G., R.K., I.P., C.V., L.L.).
ORCID: 0000-0003-3341-0156

Classifications MeSH