Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner.

Animals Female Osteocytes / metabolism Male Mice Mice, Knockout Fibronectins / metabolism Sex Factors Bone Resorption / genetics
Fndc5 hypercalcemia irisin lactation medicine mouse osteocytes osteocytic osteolysis

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
25 Apr 2024
Historique:
medline: 25 4 2024
pubmed: 25 4 2024
entrez: 25 4 2024
Statut: epublish

Résumé

Irisin, released from exercised muscle, has been shown to have beneficial effects on numerous tissues but its effects on bone are unclear. We found significant sex and genotype differences in bone from wildtype (WT) mice compared to mice lacking

Identifiants

DOI: 10.7554/eLife.92263 PMID: 38661340
pubmed: 38661340
doi: 10.7554/eLife.92263
pii: 92263
doi:
pii:

Substances chimiques

FNDC5 protein, mouse 0
Fibronectins 0

Banques de données

GEO
['GSE242445']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH Office of the Director
ID : PO1039355

Informations de copyright

© 2023, Shimonty et al.

Déclaration de conflit d'intérêts

AS, FP, MP, GP, JH, HK, CR, BS, LB No competing interests declared

Auteurs

Anika Shimonty (A)

Indiana University, Indianapolis, United States.
ORCID: 0009-0005-2954-2991

Fabrizio Pin (F)

Indiana University, Indianapolis, United States.

Matthew Prideaux (M)

Indiana University, Indianapolis, United States.
ORCID: 0000-0001-9211-9698

Gang Peng (G)

Indiana University, Indianapolis, United States.

Joshua Huot (J)

Indiana University, Indianapolis, United States.

Hyeonwoo Kim (H)

Korea Advanced Institute of Science and Technology, Daejon, Republic of Korea.

Clifford J Rosen (CJ)

Maine Health Access Foundation, Portland, United States.

Bruce M Spiegelman (BM)

Dana Farber Cancer Institute, Boston, United States.

Lynda F Bonewald (LF)

Indiana University, Indianapolis, United States.
Indiana Center for Musculoskeletal Health, Indianapolis, United States.
ORCID: 0000-0002-5536-9943

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Deletion of FNDC5/irisin modifies murine...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Ostéocytes › Deletion of FNDC5/irisin modifies murine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Deletion of FNDC5/irisin modifies murine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Deletion of FNDC5/irisin modifies murine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Fibronectines › Deletion of FNDC5/irisin modifies murine...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Deletion of FNDC5/irisin modifies murine...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Résorption osseuse › Deletion of FNDC5/irisin modifies murine...